Genomic Sequencing of Aged Nonhuman Primates at ONPRC

ONPRC 对老年非人类灵长类动物进行基因组测序

• 批准号: 10662148
• 负责人: Peter Gordon Barr-Gillespie
• 金额: $ 14.34万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-08 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10662148
• 关键词: Aging; Animals; Biomedical Research; Core Grant; DNA; DNA Sequence; DNA sequencing; Data; Databases; Disease; Genetic; Genetic Polymorphism; Genomics; Genotype; Individual; Infrastructure; Libraries; Link; Longevity; Macaca; Macaca mulatta; Maps; Oregon; Phenotype; Primates; Process; Protocols documentation; Research; Resources; Running; Sampling; Sequence Read Archive; Single Nucleotide Polymorphism; Technology; Time; United States National Institutes of Health; Variant; X Chromosome; Y Chromosome; aged; animal data; base; cost; formycin triphosphate; genetic pedigree; instrumentation; nonhuman primate; offspring; public database; reference genome; reproductive; sex; translational model

PROJECT SUMMARY The Oregon National Primate Research Center (ONPRC) is one of seven such National Primate Research Centers (NPRCs) that are sponsored by the National Institutes of Health. ONPRC is tasked to conduct scientific discovery in order to help the public live healthier, longer lives. Facilitating this process, support for ONPRC comes through the P51 Core Grant (P51-OD011092), which provides expertise, technology, and various Core- based resources. This infrastructure at ONPRC provides access to nonhuman primates (ca. 5,000 individuals), enabling a highly translational model for cutting-edge biomedical research. The genetics department at ONPRC is one of several specialized resources and they help facilitate and maintain the outbred resource locally and in coordination with the other NPRCs. Moreover, to better define individuals and their genotypic variation (for example, single nucleotide polymorphisms; SNP) the genetics staff has been performing DNAseq and compiling this information. Moreover, ONPRC is hosting similar information from other NPRCs and this data is available in an on-line format. However, due to cost and time-constraints, not to mention the large number of animals here and other NPRCs, the choice of animals to have their DNA sequenced is restrictive. Therefore, it is extremely helpful that the NIA is providing support via this project, to sequence the DNA from animals in the Primate Aging Study. This effort is interesting in other respects, such as an extended impact of having data from animals that may be well-represented in off-spring currently in the colony, which were produced over the reproductive lifespan of these individuals.

项目总结

项目成果

Contrast-enhanced ultrasound for the assessment of placental development and function.

• DOI: 10.2144/btn-2020-0069
• 发表时间: 2020-11
• 期刊: BioTechniques
• 影响因子: 2.7
• 作者: Roberts VH;Frias AE
• 通讯作者: Frias AE

Characterization of SALL2 Gene Isoforms and Targets Across Cell Types Reveals Highly Conserved Networks.

• DOI: 10.3389/fgene.2021.613808
• 发表时间: 2021
• 期刊: Frontiers in genetics
• 影响因子: 3.7
• 作者: Farkas C;Quiroz A;Alvarez C;Hermosilla V;Aylwin CF;Lomniczi A;Castro AF;Hepp MI;Pincheira R
• 通讯作者: Pincheira R

Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine.

• DOI: 10.1038/nm.4473
• 发表时间: 2018-03
• 期刊: Nature medicine
• 影响因子: 82.9
• 作者: Hansen SG;Zak DE;Xu G;Ford JC;Marshall EE;Malouli D;Gilbride RM;Hughes CM;Ventura AB;Ainslie E;Randall KT;Selseth AN;Rundstrom P;Herlache L;Lewis MS;Park H;Planer SL;Turner JM;Fischer M;Armstrong C;Zweig RC;Valvo J;Braun JM;Shankar S;Lu L;Sylwester AW;Legasse AW;Messerle M;Jarvis MA;Amon LM;Aderem A;Alter G;Laddy DJ;Stone M;Bonavia A;Evans TG;Axthelm MK;Früh K;Edlefsen PT;Picker LJ
• 通讯作者: Picker LJ

A Multifunctional and Highly Adaptable Reporter System for CRISPR/Cas Editing.

• DOI: 10.3390/ijms24098271
• 发表时间: 2023-05-05
• 期刊: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
• 影响因子: 5.6
• 作者: Wettengel, Jochen M.;Hansen-Palmus, Lea;Yusova, Sofiya;Rust, Lauren;Biswas, Sreya;Carson, Julien;Ryu, Junghyun;Bimber, Benjamin N.;Hennebold, Jon D.;Burwitz, Benjamin J.
• 通讯作者: Burwitz, Benjamin J.

Social hair pulling in captive rhesus macaques (Macaca mulatta).

• DOI: 10.1002/ajp.22720
• 发表时间: 2017-12
• 期刊: American journal of primatology
• 影响因子: 2.4
• 作者: Heagerty A;Wales RA;Prongay K;Gottlieb DH;Coleman K
• 通讯作者: Coleman K