Genomic Sequencing of Aged Nonhuman Primates at ONPRC

项目总结 俄勒冈州国家灵长类研究中心(ONPRC)是七个这样的国家灵长类研究之一 由国家卫生研究院赞助的中心(NPR)。ONPRC的任务是进行科学研究 发现，以帮助公众活得更健康、更长寿。促进这一进程，为ONPRC提供支持 来自P51 Core Grant(P51-OD011092)，它提供专业知识、技术和各种Core- 基于资源。ONPRC的这一基础设施提供了接触非人类灵长类动物(约5000只)的途径， 为尖端生物医学研究提供高度可转换的模型。 ONPRC的遗传学部门是几个专门的资源之一，他们帮助促进和维护 在当地繁殖的资源，并与其他国家资源中心协调。此外，为了更好地定义个人 以及它们的基因变异(例如，单核苷酸多态；SNP)遗传学工作人员 执行DNAseq并编译此信息。此外，ONPRC正在托管来自其他国家的类似信息 这些数据是以在线格式提供的。然而，由于成本和时间的限制，更不用说 这里的大量动物和其他NPRC，选择动物进行DNA测序是 有限制性的。因此，NIA通过这个项目提供支持是非常有帮助的，以排序 灵长类衰老研究中动物的DNA。这一努力在其他方面也很有趣，例如扩展的 拥有来自动物的数据的影响，这些动物目前在殖民地的后代中可能得到了很好的代表，这些动物 在这些个体的生殖寿命内产生。

PROJECT SUMMARY The Oregon National Primate Research Center (ONPRC) is one of seven such National Primate Research Centers (NPRCs) that are sponsored by the National Institutes of Health. ONPRC is tasked to conduct scientific discovery in order to help the public live healthier, longer lives. Facilitating this process, support for ONPRC comes through the P51 Core Grant (P51-OD011092), which provides expertise, technology, and various Core- based resources. This infrastructure at ONPRC provides access to nonhuman primates (ca. 5,000 individuals), enabling a highly translational model for cutting-edge biomedical research. The genetics department at ONPRC is one of several specialized resources and they help facilitate and maintain the outbred resource locally and in coordination with the other NPRCs. Moreover, to better define individuals and their genotypic variation (for example, single nucleotide polymorphisms; SNP) the genetics staff has been performing DNAseq and compiling this information. Moreover, ONPRC is hosting similar information from other NPRCs and this data is available in an on-line format. However, due to cost and time-constraints, not to mention the large number of animals here and other NPRCs, the choice of animals to have their DNA sequenced is restrictive. Therefore, it is extremely helpful that the NIA is providing support via this project, to sequence the DNA from animals in the Primate Aging Study. This effort is interesting in other respects, such as an extended impact of having data from animals that may be well-represented in off-spring currently in the colony, which were produced over the reproductive lifespan of these individuals.