Supplement: Long-term Effects of the Family Check-up on Depression and Suicide Across Trials and Development

项目概要 本申请作为紧急竞争修订案提交，以响应 NOT-MH-20-047“通知” 关于行政补充和紧急竞争的特别兴趣 (NOSI) 2019 年新型冠状病毒心理健康研究修订”代表了我们的范围的变化 目前资助的 R01 旨在研究 FCU 对抑郁症和抑郁症的长期交叉影响 使用三项随机试验的综合数据分析来评估自杀风险。这些随机试验包括 在幼儿期和中学接受 FCU 的儿童和家庭的大量样本。那时， FCU 作为面对面模型交付，并适用于学校和家庭交付。从那时起 目前，FCU已改编为在线版本，对中学生有效 提高育儿自我效能并减少儿童情绪问题（Stormshak 等人，2019）。鉴于 由于 COVID-19 大流行对父母和儿童的功能产生了广泛的负面影响，因此迫切需要 需要有效的以家庭为中心的预防/干预规划，可以采用远程医疗服务 在当前的大流行和未来类似规模的公共卫生危机中，以多种方式接触家庭。 拟议的行政补充措施将调整和测试家庭在线检查作为一种 治疗以促进有弹性的家庭功能，以应对 COVID-19 大流行。我们来测试一下效果 改编后的 FCU Online 计划在一项随机临床试验中的应用，该试验涉及 150 个有 10 至 14 岁青少年的家庭 年，并在 6 个月内对 4 个时间点进行了评估。我们将检查改造后的 FCU 的效果 在线了解关键的变革机制，包括养育技能、父母抑郁和父母/孩子自我保护 我们预测，监管将直接影响儿童和家庭的功能。我们预测这些关键的变化 干预的目标将影响参与者（包括青少年）对 COVID-19 大流行的反应 抑郁和行为问题，应对以流行病为中心的压力源的能力（例如处理 就业状况或职能的变化；遵循规定的安全措施）和社会/家庭 功能（包括关系支持和家庭暴力风险）。

Project Summary This application, submitted as an Urgent Competitive Revision in response to NOT-MH-20-047, “Notice of Special Interest (NOSI) regarding the Availability of Administrative Supplements and Urgent Competitive Revisions for Mental Health Research on the 2019 Novel Coronavirus,” represents a change in scope from our currently-funded R01, which seeks to examine the long-term crossover effects of the FCU on depression and suicide-risk using Integrative Data Analysis across three randomized trials. These randomized trials include a large sample of children and families who received the FCU in early childhood and middle school. At that time, the FCU was delivered as an in-person model, and was adapted for both school and home delivery. Since that time, the FCU has been adapted to an online version which has been effective with middle school youth at enhancing parenting self-efficacy and reducing child emotional problems (Stormshak et al., 2019). Given the wide-ranging negative effects of the COVID-19 pandemic on parent and child functioning, there is an urgent need for effective family-focused prevention/intervention programming that can employ telehealth-delivery formats to reach families in the midst of the current pandemic and future public health crises of similar scale. The proposed administrative supplement will adapt and test the efficacy of the Family Check-Up Online as a treatment to foster resilient family functioning in response to the COVID-19 pandemic. We will test the effects of the adapted FCU Online program in a randomized clinical trial with 150 families with youth aged 10 – 14 years, and assessed over 4 time-points across 6 months. We will examine the effects of the adapted FCU Online on key mechanisms of change, including parenting skills, parental depression, and parent/child self- regulation, that we predict will directly impact child and family functioning. We predict that changes in these key targets of the intervention will impact participant’s response to the COVID-19 pandemic, including youth depression and behavior problems, the ability to cope with pandemic-focused stressors (e.g. dealing with changes in employment status or functioning; following mandated safety measures), and social/familial functioning (including relational support and risk for domestic violence).