Division of Cancer Tratment and DIagnosis- Operational Task Order

癌症治疗和诊断司(DCTD)通过加快新制剂、生物标志物、成像测试和其他诊断和治疗干预(放射、手术、免疫治疗)的初始和后续大规模测试，支持癌症新诊断和治疗方法的开发。在DCTD内，八个主要项目和一个患者诊所合作，将独特的分子、诊断测试和治疗干预从实验室平台带到患者床边。该合同支持的活动包括：天然产物的分离和评价；分子药理学；化合物文库的高通量筛选；临床试验中药效学标志物和药代动力学分析的开发和利用；药物毒理学研究；信息系统、技术和数据科学；药物发现；放射化学和放射性药物生产；临床试验图像、体外和体内翻译研究的存档；天然产物、患者来源的异种移植、肿瘤和生物抗癌药物的存储库支持；生物制药生产设施；医疗作家；为在NIH临床中心进行的临床试验、与生物制药公司合作的相关研究提供的护理支持服务；对精确药物试验的支持；先进的基因组学能力支持临床前模型和临床试验中的肿瘤评估；NCI资助的临床试验的患者生物库；纳米技术表征和评估。

The Division of Cancer Treatment and Diagnosis (DCTD) supports the development of novel diagnostic and therapeutic approaches for cancer by expediting the initial and subsequent large-scale testing of new agents, biomarkers, imaging tests, and other diagnostic and therapeutic interventions (radiation, surgery, immunotherapy) in patients. Within DCTD, eight major programs and a patient clinic work together to bring unique molecules, diagnostic tests, and therapeutic interventions from the laboratory bench to the patient bedside. Activities supported under this contract include: isolation and evaluation of natural products; molecular pharmacology; high-throughput screening of compound libraries; pharmacodynamic marker and pharmacokinetic assay development and utilization in clinical trials; drug toxicology research; information systems, technologies, and data science; drug discovery; radiochemistry and radioactive drug production; archival of clinical trial images, in vitro and in vivo translational research; repository support for natural products, patient-derived xenografts, tumors and biologic anti-cancer agents; a biopharmaceutical production facility; medical writers; nursing support services for clinical trials performed in the NIH Clinical Center, correlative studies in collaboration with biopharmaceutical companies; support for precision medicine trials; advanced genomics capabilities supporting tumor evaluation in pre-clinical models and clinical trials; patient biorepositories for NCI-funded clinical trials; nanotechnology characterization and evaluation.