SF Bay Area MACS/WIHS Combined Cohort Study

项目摘要 MACS和WIHS是对艾滋病病毒感染的长期自然和治疗史的主要研究 美国旧金山临床研究网站(SF CRS)建议为 MACS/WIHS联合队列研究(MWCCS)通过招募和保留一名 代表本区域艾滋病毒流行的不同男女群体(即，在种族方面 和种族多样化的次优护理参与度)；继续保持对MWCCS的科学领导，包括 对与MWCCS合作的早期职业调查人员提供强有力的指导；并持续参与 MWCCS研究。登记和保留符合MWCCS的艾滋病毒携带者和有感染风险的男性和女性 目标，我们将继续实施多源招聘战略，支持以下参与者的注册 代表当地社区的病例和控制措施。我们将继续为MWCCS提供科学和 通过与数据分析和WIHS协作统一Mac和WIHS，实现结构性领导 协调中心和MWCCS执行委员会，领导新MWCCS整合科学 工作组，并通过大型机构的协作参与支持职业生涯早期调查人员 SF CRS高级调查人员的核心(5人获得K24奖项)，他们拥有出色的指导技能，具有 培养新一代熟练的翻译科学家的目标。SF CRS将在以下方面发挥领导作用 对MWCCS科学议程至关重要的几个领域，包括艾滋病毒发病机制， 神经认知障碍和脑结构/功能，基因组学，心脏电生理学，药理学， 信息学和共生症。具体地说，我们建议：1)促进对艾滋病毒的了解 通过对外周血、肠道组织、宫颈和宫颈组织中的白细胞进行深入的表型鉴定 2)研究HIV与性腺老化与神经认知功能障碍的关系； 3)开展新的心电图研究，以评估亚临床心脏和神经认知损伤 PLWH；4)利用相关研究来更好地理解多种疾病(例如，心脏、 外周血管、肝、肾、肺、神经认知、身体功能；以及5)铅基因组(例如， 在MWCCS中评估的结果的(遗传、表观遗传、线粒体)发现努力。

Project Summary The MACS and WIHS are major studies of the long-term natural and treated history of HIV infection in the U.S. The San Francisco Clinical Research Site (SF CRS) proposes to make vital contributions to the MACS/WIHS Combined Cohort Study (MWCCS) scientific agenda through the recruitment and retention of a diverse group of women and men whom are representative of the HIV epidemic in our region (i.e., racially and ethnically diverse, sub-optimal engagement in care); continued scientific leadership of MWCCS including strong mentoring of early career investigators who work with MWCCS; and consistent participation in MWCCS studies. To enroll and retain both men and women with and at risk for HIV consistent with MWCCS targets, we will continue a strategy of multisource recruiting that supports enrollment of participants who represent cases and controls in the local community. We will continue to provide MWCCS scientific and structural leadership by unifying the MACS and WIHS in collaboration with the data analysis and coordination center and the MWCCS Executive Committee, leading new MWCCS integrated scientific working groups, and supporting early career investigators through the collaborative engagement of a large core of senior SF CRS investigators (five with K24 awards) who have outstanding mentorship skills, with the goal of developing a new generation of skilled translational scientists. The SF CRS will provide leadership in several domains of vital importance to the MWCCS scientific agenda including HIV pathogenesis, neurocognitive impairment and brain structure/function, genomics, cardiac electrophysiology, pharmacology, informatics, and comorbidities. Specifically, we propose to: 1) contribute to the understanding of the HIV reservoir through deep phenotyping of leukocyte populations in peripheral blood, gut tissue, endocervical and seminal cells; 2) examine the relationship of HIV and gonadal aging on deficits in neurocognitive functioning; 3) pursue novel electrocardiographic studies to evaluate subclinical cardiac and neurocognitive injury in PLWH; 4) leverage linked studies to better understand inter-relationships of multiple morbidities (e.g., cardiac, peripheral vascular, hepatic, renal, pulmonary, neurocognitive, physical function; and 5) lead genomic (e.g., genetic, epigenetic, mitochondrial) discovery efforts on the outcomes evaluated in the MWCCS.