SF Bay Area MACS/WIHS Combined Cohort Study

旧金山湾区 MACS/WIHS 联合队列研究

• 批准号: 10221402
• 负责人: Bradley E Aouizerat
• 金额: $ 46.28万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10221402
• 关键词: 3-Dimensional; Aging; Anti-Retroviral Agents; Area; Biological; Blood Vessels; Brain; Cardiac; Cardiac Electrophysiologic Techniques; Cardiovascular Diseases; Caring; Cells; Clinical; Cohort Studies; Collaborations; Communities; Data; Data Analyses; Disease; Enrollment; Epidemic; Epigenetic Process; Ethnic Origin; Fibrinogen; Fibrosis; Funding; Generations; Genetic; Genomics; Goals; HIV; HIV Infections; Hepatic; Immune; Informatics; Injury; Kidney; Knowledge; Lead; Leadership; Leukocytes; Link; Longitudinal Studies; Lung; Malignant Neoplasms; Mass Spectrum Analysis; Measures; Mentors; Mentorship; Methods; Mid-Career Clinical Scientist Award (K24); Mitochondria; Morbidity - disease rate; Neurocognition; Neurocognitive; Neurocognitive Deficit; Organ; Outcome; Output; Ovarian aging; Participant; Pathogenesis; Pathway interactions; Peripheral; Pharmaceutical Preparations; Pharmacogenomics; Pharmacology; Phenotype; Physical Function; Physiology; Population; Process; Race; Recording of previous events; Renal function; Research; Research Personnel; Respiratory physiology; Risk; San Francisco; Seminal; Source; Specimen; Structure; Testing; Tissues; United States; United States National Institutes of Health; Woman; Women' s Group; Work; biological sex; career; career development; case control; clinical research site; cognitive task; cohort; comorbidity; comparison group; cost effective; epigenomics; ethnic diversity; genomic data; healthspan; liver function; liver injury; men; multiple chronic conditions; neuroimaging; novel; peripheral blood; psychosocial; racial diversity; recruit; sex; skills; social group; translational scientist; vascular injury; working group

Project Summary The MACS and WIHS are major studies of the long-term natural and treated history of HIV infection in the U.S. The San Francisco Clinical Research Site (SF CRS) proposes to make vital contributions to the MACS/WIHS Combined Cohort Study (MWCCS) scientific agenda through the recruitment and retention of a diverse group of women and men whom are representative of the HIV epidemic in our region (i.e., racially and ethnically diverse, sub-optimal engagement in care); continued scientific leadership of MWCCS including strong mentoring of early career investigators who work with MWCCS; and consistent participation in MWCCS studies. To enroll and retain both men and women with and at risk for HIV consistent with MWCCS targets, we will continue a strategy of multisource recruiting that supports enrollment of participants who represent cases and controls in the local community. We will continue to provide MWCCS scientific and structural leadership by unifying the MACS and WIHS in collaboration with the data analysis and coordination center and the MWCCS Executive Committee, leading new MWCCS integrated scientific working groups, and supporting early career investigators through the collaborative engagement of a large core of senior SF CRS investigators (five with K24 awards) who have outstanding mentorship skills, with the goal of developing a new generation of skilled translational scientists. The SF CRS will provide leadership in several domains of vital importance to the MWCCS scientific agenda including HIV pathogenesis, neurocognitive impairment and brain structure/function, genomics, cardiac electrophysiology, pharmacology, informatics, and comorbidities. Specifically, we propose to: 1) contribute to the understanding of the HIV reservoir through deep phenotyping of leukocyte populations in peripheral blood, gut tissue, endocervical and seminal cells; 2) examine the relationship of HIV and gonadal aging on deficits in neurocognitive functioning; 3) pursue novel electrocardiographic studies to evaluate subclinical cardiac and neurocognitive injury in PLWH; 4) leverage linked studies to better understand inter-relationships of multiple morbidities (e.g., cardiac, peripheral vascular, hepatic, renal, pulmonary, neurocognitive, physical function; and 5) lead genomic (e.g., genetic, epigenetic, mitochondrial) discovery efforts on the outcomes evaluated in the MWCCS.

项目概要 MACS 和 WIHS 是对 HIV 感染的长期自然史和治疗史的主要研究。 美国旧金山临床研究中心 (SF CRS) 提议为 MACS/WIHS 联合队列研究 (MWCCS) 科学议程通过招募和保留 代表我们地区艾滋病毒流行的不同女性和男性群体（即种族 以及种族多样化、护理参与度次优）； MWCCS 持续的科学领导地位，包括 对参与 MWCCS 的早期职业调查员提供强有力的指导；并持续参与 MWCCS 研究。根据 MWCCS 招募和留住患有艾滋病毒和有感染艾滋病毒风险的男性和女性 目标，我们将继续采取多源招募战略，支持以下参与者的注册 代表当地社区的病例和控制措施。我们将继续为 MWCCS 提供科学和 通过将 MACS 和 WIHS 与数据分析和协作相结合来实现结构领导力 协调中心和 MWCCS 执行委员会，领导新的 MWCCS 综合科学 工作组，并通过大量人员的协作参与来支持早期职业调查人员 SF CRS 高级调查员核心（五名获得 K24 奖项），他们具有出色的指导能力， 培养新一代熟练的转化科学家的目标。 SF CRS 将在以下方面发挥领导作用： 对 MWCCS 科学议程至关重要的几个领域，包括艾滋病毒发病机制、 神经认知障碍和大脑结构/功能、基因组学、心脏电生理学、药理学、 信息学和合并症。具体来说，我们建议：1）促进对艾滋病毒的了解 通过对外周血、肠道组织、宫颈内膜和 精细胞； 2）检查艾滋病毒和性腺衰老与神经认知功能缺陷的关系； 3）开展新的心电图研究，以评估亚临床心脏和神经认知损伤 感染者和艾滋病患者； 4) 利用关联研究更好地了解多种疾病之间的相互关系（例如心脏病、 周围血管、肝、肾、肺、神经认知、身体功能； 5) 主要基因组（例如， 遗传、表观遗传、线粒体）发现工作对 MWCCS 中评估的结果进行。