SF Bay Area MACS/WIHS Combined Cohort Study
旧金山湾区 MACS/WIHS 联合队列研究
基本信息
- 批准号:10221402
- 负责人:
- 金额:$ 46.28万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-04-01 至 2026-03-31
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAgingAnti-Retroviral AgentsAreaBiologicalBlood VesselsBrainCardiacCardiac Electrophysiologic TechniquesCardiovascular DiseasesCaringCellsClinicalCohort StudiesCollaborationsCommunitiesDataData AnalysesDiseaseEnrollmentEpidemicEpigenetic ProcessEthnic OriginFibrinogenFibrosisFundingGenerationsGeneticGenomicsGoalsHIVHIV InfectionsHepaticImmuneInformaticsInjuryKidneyKnowledgeLeadLeadershipLeukocytesLinkLongitudinal StudiesLungMalignant NeoplasmsMass Spectrum AnalysisMeasuresMentorsMentorshipMethodsMid-Career Clinical Scientist Award (K24)MitochondriaMorbidity - disease rateNeurocognitionNeurocognitiveNeurocognitive DeficitOrganOutcomeOutputOvarian agingParticipantPathogenesisPathway interactionsPeripheralPharmaceutical PreparationsPharmacogenomicsPharmacologyPhenotypePhysical FunctionPhysiologyPopulationProcessRaceRecording of previous eventsRenal functionResearchResearch PersonnelRespiratory physiologyRiskSan FranciscoSeminalSourceSpecimenStructureTestingTissuesUnited StatesUnited States National Institutes of HealthWomanWomen&aposs GroupWorkbiological sexcareercareer developmentcase controlclinical research sitecognitive taskcohortcomorbiditycomparison groupcost effectiveepigenomicsethnic diversitygenomic datahealthspanliver functionliver injurymenmultiple chronic conditionsneuroimagingnovelperipheral bloodpsychosocialracial diversityrecruitsexskillssocial grouptranslational scientistvascular injuryworking group
项目摘要
Project Summary
The MACS and WIHS are major studies of the long-term natural and treated history of HIV infection in the
U.S. The San Francisco Clinical Research Site (SF CRS) proposes to make vital contributions to the
MACS/WIHS Combined Cohort Study (MWCCS) scientific agenda through the recruitment and retention of a
diverse group of women and men whom are representative of the HIV epidemic in our region (i.e., racially
and ethnically diverse, sub-optimal engagement in care); continued scientific leadership of MWCCS including
strong mentoring of early career investigators who work with MWCCS; and consistent participation in
MWCCS studies. To enroll and retain both men and women with and at risk for HIV consistent with MWCCS
targets, we will continue a strategy of multisource recruiting that supports enrollment of participants who
represent cases and controls in the local community. We will continue to provide MWCCS scientific and
structural leadership by unifying the MACS and WIHS in collaboration with the data analysis and
coordination center and the MWCCS Executive Committee, leading new MWCCS integrated scientific
working groups, and supporting early career investigators through the collaborative engagement of a large
core of senior SF CRS investigators (five with K24 awards) who have outstanding mentorship skills, with the
goal of developing a new generation of skilled translational scientists. The SF CRS will provide leadership in
several domains of vital importance to the MWCCS scientific agenda including HIV pathogenesis,
neurocognitive impairment and brain structure/function, genomics, cardiac electrophysiology, pharmacology,
informatics, and comorbidities. Specifically, we propose to: 1) contribute to the understanding of the HIV
reservoir through deep phenotyping of leukocyte populations in peripheral blood, gut tissue, endocervical and
seminal cells; 2) examine the relationship of HIV and gonadal aging on deficits in neurocognitive functioning;
3) pursue novel electrocardiographic studies to evaluate subclinical cardiac and neurocognitive injury in
PLWH; 4) leverage linked studies to better understand inter-relationships of multiple morbidities (e.g., cardiac,
peripheral vascular, hepatic, renal, pulmonary, neurocognitive, physical function; and 5) lead genomic (e.g.,
genetic, epigenetic, mitochondrial) discovery efforts on the outcomes evaluated in the MWCCS.
项目摘要
MACS和WIHS是对艾滋病病毒感染的长期自然和治疗史的主要研究
美国旧金山临床研究网站(SF CRS)建议为
MACS/WIHS联合队列研究(MWCCS)通过招募和保留一名
代表本区域艾滋病毒流行的不同男女群体(即,在种族方面
和种族多样化的次优护理参与度);继续保持对MWCCS的科学领导,包括
对与MWCCS合作的早期职业调查人员提供强有力的指导;并持续参与
MWCCS研究。登记和保留符合MWCCS的艾滋病毒携带者和有感染风险的男性和女性
目标,我们将继续实施多源招聘战略,支持以下参与者的注册
代表当地社区的病例和控制措施。我们将继续为MWCCS提供科学和
通过与数据分析和WIHS协作统一Mac和WIHS,实现结构性领导
协调中心和MWCCS执行委员会,领导新MWCCS整合科学
工作组,并通过大型机构的协作参与支持职业生涯早期调查人员
SF CRS高级调查人员的核心(5人获得K24奖项),他们拥有出色的指导技能,具有
培养新一代熟练的翻译科学家的目标。SF CRS将在以下方面发挥领导作用
对MWCCS科学议程至关重要的几个领域,包括艾滋病毒发病机制,
神经认知障碍和脑结构/功能,基因组学,心脏电生理学,药理学,
信息学和共生症。具体地说,我们建议:1)促进对艾滋病毒的了解
通过对外周血、肠道组织、宫颈和宫颈组织中的白细胞进行深入的表型鉴定
2)研究HIV与性腺老化与神经认知功能障碍的关系;
3)开展新的心电图研究,以评估亚临床心脏和神经认知损伤
PLWH;4)利用相关研究来更好地理解多种疾病(例如,心脏、
外周血管、肝、肾、肺、神经认知、身体功能;以及5)铅基因组(例如,
在MWCCS中评估的结果的(遗传、表观遗传、线粒体)发现努力。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Bradley E Aouizerat其他文献
1103-194 Identification of novel genetic markers associated with risk of myocardial infarction from a genomic scale scan of putative functional polmorphisms
- DOI:
10.1016/s0735-1097(04)92064-5 - 发表时间:
2004-03-03 - 期刊:
- 影响因子:
- 作者:
Dov Shiffman;May Luke;Olga Iakoubova;Bradley E Aouizerat;Christian A Zellner;Clive R Pullinger;Denis W Drew;Joseph J Catanese;Diane U Leong;Dongming Liu;Judy Z Louie;David Lew;Carmen H Tong;David A Ross;Linda B McAllister;Charles M Rowland;Kit F Lau;James J Devlin;Mary J Malloy;John P Kane - 通讯作者:
John P Kane
Bradley E Aouizerat的其他文献
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{{ truncateString('Bradley E Aouizerat', 18)}}的其他基金
Proteomic Profiling of Cardiac Dysfunction in the MACS-WIHS Combined Cohort Study
MACS-WIHS 联合队列研究中心脏功能障碍的蛋白质组学分析
- 批准号:
10658720 - 财政年份:2019
- 资助金额:
$ 46.28万 - 项目类别:
SF Bay Area MACS/WIHS Combined Cohort Study
旧金山湾区 MACS/WIHS 联合队列研究
- 批准号:
10202118 - 财政年份:2019
- 资助金额:
$ 46.28万 - 项目类别:
Assessing Function and Performance of Population Sexual Orientation and Gender Identity (SOGI) Research Measures in a Racially Diverse HIV-Specific National Cohort
评估不同种族的艾滋病毒特定国家队列中人口性取向和性别认同 (SOGI) 研究措施的功能和表现
- 批准号:
10334307 - 财政年份:2019
- 资助金额:
$ 46.28万 - 项目类别:
SF Bay Area MACS/WIHS Combined Cohort Study
旧金山湾区 MACS/WIHS 联合队列研究
- 批准号:
10225047 - 财政年份:2019
- 资助金额:
$ 46.28万 - 项目类别:
SF Bay Area MACS/WIHS Combined Cohort Study
旧金山湾区 MACS/WIHS 联合队列研究
- 批准号:
9904785 - 财政年份:2019
- 资助金额:
$ 46.28万 - 项目类别:
SF Bay Area MACS/WIHS Combined Cohort Study
旧金山湾区 MACS/WIHS 联合队列研究
- 批准号:
10612720 - 财政年份:2019
- 资助金额:
$ 46.28万 - 项目类别:
SF Bay Area MACS/WIHS Combined Cohort Study
旧金山湾区 MACS/WIHS 联合队列研究
- 批准号:
10371250 - 财政年份:2019
- 资助金额:
$ 46.28万 - 项目类别:
SF Bay Area MACS/WIHS Combined Cohort Study
旧金山湾区 MACS/WIHS 联合队列研究
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10392771 - 财政年份:2019
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$ 46.28万 - 项目类别:
Feature selection of DNA methylation biosignatures for neuropathy with comorbid drug abuse in the setting of HIV infection
HIV 感染背景下合并药物滥用的神经病 DNA 甲基化生物印记的特征选择
- 批准号:
10404953 - 财政年份:2018
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Defining the impact of injection drug use on antiretroviral therapy and HIV treatment outcomes: an (epi)genomic approach
定义注射吸毒对抗逆转录病毒治疗和艾滋病毒治疗结果的影响:(表观)基因组方法
- 批准号:
9976483 - 财政年份:2018
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