Improving Research Resources at the TNPRC to Support COVID-19 Research

项目摘要/摘要 杜兰国家灵长类研究中心(TNPRC)是七个国家灵长类研究中心之一 (NPRCs)由美国国立卫生研究院赞助。该中心致力于提供基础设施 以及支持基础和应用研究工作，以促进科学知识和改善人与环境 动物健康和福祉。为核心和附属科学家提供的资源包括 非人灵长类动物和最先进的研究仪器。 TNPRC拥有美国最大的印度原产恒河猴繁殖地之一。完毕 在过去的五年里，这些殖民地每年生产200-900只婴儿，提供了近2000只动物 用于生物医学研究项目。目前，对无特定病原体(SPF)猕猴的需求很高 在国家一级，这需要持续获得这些资源。TNPRC P51基本补助金(P51 OD011104)提供资金支持和维护这个殖民地，而两个U42赠款和计划收入 从动物销售中获得额外资金。持续支持SPF菌落的适度扩展 将继续来自TNPRC P51基本赠款和U42赠款以外的来源，包括计划 来自出售动物、建筑补助和补充剂的收入。 各种核心实验室支持TNPRC的研究和动物护理活动，包括新成立的 高遏制研究性能核心。该核心包括BSL-2和BSL-3空间，并运行 在质量保证模式下，以提高严密性和可重复性。这些实验室配备了高性能的 用于从非人类灵长类动物研究中产生高质量数据的终端仪器。增设实验室 需要设备来支持迅速扩大和迫切需要的冠状病毒研究计划。 P51基本补助金的这一补充将用于增加一个新的户外住房外壳，使用户能够使用 另一个现有的围栏在繁殖群体校园内，并提供资金购买研究 仪器仪表。拟议的繁殖群体围栏将用于安置SPF动物，并已 旨在最大限度地提高可用资金的容量和灵活性，并提供新颖且经过验证的 环境增强组件。非人灵长类动物住房和设备资源的增加 符合父级奖项的目标。从这些改进中实现的好处将有助于我们的努力 增强对核心和附属科学家新冠肺炎研究计划的支持能力。

PROJECT SUMMARY/ABSTRACT The Tulane National Primate Research Center (TNPRC) is one of seven National Primate Research Centers (NPRCs) sponsored by the National Institutes of Health. The Center is dedicated to providing the infrastructure and support for basic and applied research efforts to advance scientific knowledge and improve human and animal health and wellbeing. Resources provided to core and affiliate scientists include well-characterized nonhuman primates and state-of-the-art research instrumentation. The TNPRC has one of the largest Indian-origin rhesus monkey breeding colonies in the United States. Over the past five years, these colonies produced between 200-900 infants a year and provided close to 2,000 animals for biomedical research programs. Currently, there is high demand for specific pathogen free (SPF) macaques on a national level, which requires continued availability of these resources. The TNPRC P51 base grant (P51 OD011104) provides funds to support and maintain this colony, while two U42 grants and program income derived from animal sales supply additional funds. Ongoing support for moderate expansion of the SPF colony will continue to come from sources other than the TNPRC P51 base grant and U42 grants, including program income from the sale of animals, construction grants, and supplements. A variety of core laboratories support TNPRC research and animal care activities, including a newly established High Containment Research Performance Core. This core includes both BSL-2 and BSL-3 spaces and operates under a quality assurance model to enhance rigor and reproducibility. These laboratories are equipped with high- end instrumentation used to generate high quality data from nonhuman primate research. Additional laboratory equipment is needed to support a rapidly expanding and critically needed coronavirus research program. This supplement to the P51 base grant will be used to add one new outdoor housing enclosure, enable use of another existing enclosure on the breeding colony campus, and to provide funds for purchase of research instrumentation. The proposed breeding colony enclosures will be used to house SPF animals and have been designed to maximize capacity and flexibility for the available funding and to provide novel and proven environmental enhancement components. The addition of nonhuman primate housing and equipment resources falls within the goals of the parent award. The benefits realized from these improvements will assist our efforts to enhance our capability to support core and affiliate scientists’ COVID-19 research programs.