The Effects of Sex Hormones on Chlamydia Infection

性激素对衣原体感染的影响

基本信息

  • 批准号:
    10190235
  • 负责人:
  • 金额:
    $ 20.26万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-04-20 至 2026-03-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY Chlamydia trachomatis is the leading cause of sexually transmitted infections of bacterial origin worldwide. No vaccines are available, infections are often asymptomatic, and if left untreated, long-term sequelae have an adverse effect on women reproductive health. The primary site of infection is the endocervical epithelium, where the bacteria replicates in the host cell cytosol within a membrane-bound compartment called the inclusion. Interventions to prevent the establishment of the Chlamydia replicative niche would reduce vaginal shedding (i.e. transmission) and ascension to the upper reproductive tract (i.e. long-term pathology). It is more and more appreciated that the state of the tissue at the time of infection most likely dictates the outcome of infection; however, little is known about intrinsic and extrinsic factors that collectively prime individual cells within the tissue. Human epidemiological studies, murine and cell culture models of infection, have been used to gain a better understanding of these processes; however, there are substantial limitations with these models. To address this gap, in close collaboration with the Biomimetic Models Core, we will use a human three-dimensional biomimetic cervicovaginal model of chlamydial infection and investigate the effects of sex hormones on C. trachomatis infection. We will assess bacterial growth (Aim 1), tissue integrity and physiology (Aim 2) and the immune response (Aim 3). Altogether, the exposure of ex vivo reconstituted cervicovaginal tissue in its physiological environment to infectious chlamydiae will offer a unique model system to characterize if and how sex hormones influence susceptibility to C. trachomatis infection. In the long term, this model will be applicable to the study of fundamental processes related to any sexually transmitted pathogen and will offer a relatively simple and cost- effective way for testing novel therapies to control the spread of sexually transmitted infections.
项目摘要 沙眼衣原体是全世界细菌性传播感染的主要原因。没有 疫苗是可用的,感染往往是无症状的,如果不治疗,长期后遗症有 对妇女生殖健康的不利影响。感染的主要部位是子宫颈内上皮, 细菌在宿主细胞胞质溶胶中在称为内含物的膜结合区室中复制。 预防衣原体复制生态位建立的干预措施将减少阴道脱落(即, 传播)和Ascension到上生殖道(即长期病理)。显得越来越 应当理解,感染时组织的状态最有可能决定感染的结果; 然而,人们对共同激发组织内单个细胞的内在和外在因素知之甚少。 人类流行病学研究、小鼠和细胞培养感染模型已被用于获得更好的 然而,这些模型有很大的局限性。为了解决这个 gap,与仿生模型核心密切合作,我们将使用人类三维仿生 宫颈阴道衣原体感染模型,探讨性激素对衣原体感染的影响。沙眼衣原体 感染我们将评估细菌生长(目标1)、组织完整性和生理学(目标2)以及免疫 响应(目标3)。总之,离体重构的宫颈阴道组织在其生理条件下的暴露是有利的。 环境传染性衣原体将提供一个独特的模型系统,以表征性激素是否以及如何 影响对C.沙眼感染从长远来看,这一模式将适用于研究 与任何性传播病原体有关的基本过程,并将提供一个相对简单和成本- 测试新疗法的有效方法,以控制性传播感染的传播。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

ISABELLE DERRE其他文献

ISABELLE DERRE的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('ISABELLE DERRE', 18)}}的其他基金

The Effects of Sex Hormones on Chlamydia Infection
性激素对衣原体感染的影响
  • 批准号:
    10596516
  • 财政年份:
    2021
  • 资助金额:
    $ 20.26万
  • 项目类别:
The Effects of Sex Hormones on Chlamydia Infection
性激素对衣原体感染的影响
  • 批准号:
    10395583
  • 财政年份:
    2021
  • 资助金额:
    $ 20.26万
  • 项目类别:
Host-pathogen interactions controlling Chlamydia developmental cycle
宿主-病原体相互作用控制衣原体发育周期
  • 批准号:
    10456920
  • 财政年份:
    2021
  • 资助金额:
    $ 20.26万
  • 项目类别:
Regulation and composition of ER-inclusion contacts at key stages of the Chlamydia developmental cycle
衣原体发育周期关键阶段 ER 包涵体接触的调控和组成
  • 批准号:
    10352503
  • 财政年份:
    2021
  • 资助金额:
    $ 20.26万
  • 项目类别:
Host-pathogen interactions controlling Chlamydia developmental cycle
宿主-病原体相互作用控制衣原体发育周期
  • 批准号:
    10275536
  • 财政年份:
    2021
  • 资助金额:
    $ 20.26万
  • 项目类别:
Host-pathogen interactions controlling Chlamydia developmental cycle
宿主-病原体相互作用控制衣原体发育周期
  • 批准号:
    10656443
  • 财政年份:
    2021
  • 资助金额:
    $ 20.26万
  • 项目类别:
Regulation and composition of ER-inclusion contacts at key stages of the Chlamydia developmental cycle
衣原体发育周期关键阶段 ER 包涵体接触的调控和组成
  • 批准号:
    10528480
  • 财政年份:
    2021
  • 资助金额:
    $ 20.26万
  • 项目类别:
Endometrial organoids to model Chlamydia infection
子宫内膜类器官模拟衣原体感染
  • 批准号:
    9807600
  • 财政年份:
    2019
  • 资助金额:
    $ 20.26万
  • 项目类别:
ER-Chlamydia Inclusion Membrane Contact Sites
ER-衣原体包涵体膜接触位点
  • 批准号:
    8629920
  • 财政年份:
    2014
  • 资助金额:
    $ 20.26万
  • 项目类别:
ER-Chlamydia Inclusion Membrane Contact Sites
ER-衣原体包涵体膜接触位点
  • 批准号:
    9064073
  • 财政年份:
    2014
  • 资助金额:
    $ 20.26万
  • 项目类别:

相似海外基金

Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
  • 批准号:
    MR/S03398X/2
  • 财政年份:
    2024
  • 资助金额:
    $ 20.26万
  • 项目类别:
    Fellowship
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
  • 批准号:
    2338423
  • 财政年份:
    2024
  • 资助金额:
    $ 20.26万
  • 项目类别:
    Continuing Grant
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
  • 批准号:
    EP/Y001486/1
  • 财政年份:
    2024
  • 资助金额:
    $ 20.26万
  • 项目类别:
    Research Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
  • 批准号:
    MR/X03657X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 20.26万
  • 项目类别:
    Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
  • 批准号:
    2348066
  • 财政年份:
    2024
  • 资助金额:
    $ 20.26万
  • 项目类别:
    Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
  • 批准号:
    AH/Z505481/1
  • 财政年份:
    2024
  • 资助金额:
    $ 20.26万
  • 项目类别:
    Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10107647
  • 财政年份:
    2024
  • 资助金额:
    $ 20.26万
  • 项目类别:
    EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
  • 批准号:
    2341402
  • 财政年份:
    2024
  • 资助金额:
    $ 20.26万
  • 项目类别:
    Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10106221
  • 财政年份:
    2024
  • 资助金额:
    $ 20.26万
  • 项目类别:
    EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
  • 批准号:
    AH/Z505341/1
  • 财政年份:
    2024
  • 资助金额:
    $ 20.26万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了