Regulation and composition of ER-inclusion contacts at key stages of the Chlamydia developmental cycle
衣原体发育周期关键阶段 ER 包涵体接触的调控和组成
基本信息
- 批准号:10352503
- 负责人:
- 金额:$ 19.22万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-12-01 至 2023-11-30
- 项目状态:已结题
- 来源:
- 关键词:AntibioticsBacteriaBacterial InfectionsBiologicalBiotinC-terminalCell membraneCellsCellular biologyChlamydiaChlamydia InfectionsChlamydia trachomatisCholesterolCicatrixCommunicationComplexCytolysisDataDevelopmentEctopic PregnancyEndoplasmic ReticulumEnsureEnvironmentEpithelialFemaleFunctional disorderGrowthImmunityInfectionInfertilityIntegration Host FactorsLabelLeadLeftLipidsMediatingMembraneMembrane BiologyMembrane ProteinsMicrobiologyMolecularOrganellesPelvic Inflammatory DiseasePhasePhosphorylationPhosphotransferasesProcessProteinsProteomeRegulationReproductive HealthRoleSerineSexually Transmitted DiseasesSiteStructureTestingTimeTissuesVaccinesWomanWorkdesignfollow-upgenital infectionhuman diseasenovelpathogenpathogenic bacteriapreventrecruitreproductive organtherapeutically effectivetrafficking
项目摘要
SUMMARY
Chlamydia trachomatis is the leading cause of sexually transmitted infections of bacterial origin worldwide.
Vaccines are not available. Infections are often asymptomatic and left untreated, resulting in tissue scarring and
long-term consequences on female reproductive health. C. trachomatis is an obligate intracellular bacterial path-
ogen that undergoes a bi-phasic development cycle within a membrane bound compartment termed the inclu-
sion. To thrive in this confined environment, C. trachomatis must interact with cytosolic host factors and orga-
nelles, a process mediated by the insertion of Chlamydia specific Inclusion membrane proteins (Inc proteins)
into the inclusion membrane. One such interaction is the intimate contact between discrete sections of the inclu-
sion membrane and the endoplasmic reticulum (ER). These structures are referred to as ER-Inclusion membrane
contact sites (MCS). Our initial characterization of ER-Inclusion MCS indicates an enrichment in Inc proteins and
host factors with functional, tethering and regulatory capacities. Depletion of some of these components is
detrimental to bacterial growth, underscoring the important role of ER-Inclusion MCS in establishing the
replicative niche. ER-Inclusion MCS are observed throughout the developmental cycle; however, it remains
unclear if and how functional, structural and regularoty components cooperate in the temporal assembly and
dissambly of the contact, and enrichment of specific components. Here we will investigate how ER-Inclusion
MCS assembly is regulated (Aim 1) and if association of specific components varies depending on the stage of
the developmental cycle (Aim 2). Altogether, the proposed studies will elucidate how components of ER-Inclusion
MCS allows for the establishment of the C. trachomatis replicative niche, which will guide the design of effective
therapeutics.
总结
项目成果
期刊论文数量(0)
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会议论文数量(0)
专利数量(0)
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{{ truncateString('ISABELLE DERRE', 18)}}的其他基金
The Effects of Sex Hormones on Chlamydia Infection
性激素对衣原体感染的影响
- 批准号:
10190235 - 财政年份:2021
- 资助金额:
$ 19.22万 - 项目类别:
The Effects of Sex Hormones on Chlamydia Infection
性激素对衣原体感染的影响
- 批准号:
10395583 - 财政年份:2021
- 资助金额:
$ 19.22万 - 项目类别:
Host-pathogen interactions controlling Chlamydia developmental cycle
宿主-病原体相互作用控制衣原体发育周期
- 批准号:
10456920 - 财政年份:2021
- 资助金额:
$ 19.22万 - 项目类别:
The Effects of Sex Hormones on Chlamydia Infection
性激素对衣原体感染的影响
- 批准号:
10596516 - 财政年份:2021
- 资助金额:
$ 19.22万 - 项目类别:
Host-pathogen interactions controlling Chlamydia developmental cycle
宿主-病原体相互作用控制衣原体发育周期
- 批准号:
10275536 - 财政年份:2021
- 资助金额:
$ 19.22万 - 项目类别:
Host-pathogen interactions controlling Chlamydia developmental cycle
宿主-病原体相互作用控制衣原体发育周期
- 批准号:
10656443 - 财政年份:2021
- 资助金额:
$ 19.22万 - 项目类别:
Regulation and composition of ER-inclusion contacts at key stages of the Chlamydia developmental cycle
衣原体发育周期关键阶段 ER 包涵体接触的调控和组成
- 批准号:
10528480 - 财政年份:2021
- 资助金额:
$ 19.22万 - 项目类别:
Endometrial organoids to model Chlamydia infection
子宫内膜类器官模拟衣原体感染
- 批准号:
9807600 - 财政年份:2019
- 资助金额:
$ 19.22万 - 项目类别:
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