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Predicting cognitive function: Biomarkers and economics in a rural aged cohort

预测认知功能：农村老年人群的生物标志物和经济学

基本信息

批准号：
10190068
负责人：
MARY Heather WEST GREENLEE
金额：
$ 22.76万
依托单位：
IOWA STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-01 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10190068
关键词：
Address Adult Children Affect Aging Agriculture Archives Behavior Biological Biological Markers Body mass index COVID-19 COVID-19 pandemic Characteristics Child Chronic Disease Collection Communities Data Data Analyses Development Diabetes Mellitus Disease Management Economics Elderly Exercise Failure Family Family Process Financial Hardship Funding Future Gender Generations Goals Health Health Status Hypertension Individual International Life Life Experience Light Longitudinal Studies Mission Occupational Parent-Child Relations Participant Personality Traits Population Positioning Attribute Process Public Health Recommendation Research Resources Risk Rural Smoking Social Behavior Social Policies Social isolation Stress Thick Time Visit Vulnerable Populations Well in self Work aged aging population cognitive function cohort economic impact emotional distress intergenerational middle age next generation pandemic disease parent grant preventive intervention programs prospective resilience response retinal nerve fiber layer rural families social social stress social stressor stressor substance use therapy design transmission process vascular risk factor welfare

项目摘要

PROJECT ABSTRACT Older adults are one of the populations most vulnerable to COVID-19. The unprecedented economic disruption and social isolation caused by the pandemic may disproportionately cause long-lasting and potentially irreversible negative impacts to this at-risk group. The proposed research will focus on economic circumstances and social behaviors that affect the health and welfare of over 800 older adult participants and their ~400 middle-aged adult children. We will utilize the Family Transitions Project, that originally began as a study of the rural family response to the severe recession in the agricultural economy in the U.S. during the 1980s and continues to this day. Thus, we are uniquely positioned to examine the impacts of the COVID-19 pandemic on individuals and families in the context of over 30 years of accumulated prospective data. The proposed work will assess how COVID-19-associated changes in economic and social circumstances impact the health and welfare of individuals across two generations of families. We propose to examine individual and family adjustment to economic circumstances and stressors that are affected by personal characteristics and life experiences, and make recommendations regarding new programs and social policies that increase resiliency of vulnerable populations in future crises. The goals of the parent grant are to systematically evaluate cognitive function in a normative aging population and assess its association with retinal nerve fiber layer thickness and proximal and cumulative economic and social stress, and to quantify how biological variables related to vascular risk factors (BMI, hypertension, smoking), as well as gender, moderate these associations. This supplement will enhance this work by addressing these questions in the context of the COVID-19 pandemic. The aims to be addressed using supplementary funds are: (1) Investigate the impacts of the COVID-19 pandemic on the health of older adults and their middle-aged adult children. We will evaluate the extent to which COVID- 19-associated economic and social stressors, such as financial hardship and emotional distress, have impacted individuals’ health status, management of pre-existing chronic diseases (e.g., diabetes), behaviors that affect health (e.g., smoking, substance use, exercising), and cognitive functioning. (2) Investigate the impacts of the COVID-19 pandemic on family welfare across generations. We will assess the impact of economic and social stressors resulting from COVID-19 on social behaviors and family functioning between generations. During this time of crisis, we will examine the intergenerational transmission of economic circumstances, emotional well-being, and social behaviors (e.g. substance use) and assess the impact of COVID-19 stressors on family processes such as the quality of marital and parent- child relationships.

项目摘要老年人是最容易感染COVID-19的人群之一。空前的经济大流行病造成的破坏和社会孤立可能不成比例地造成长期和对这一高危群体可能造成不可逆转的负面影响。拟议的研究将侧重于影响800多名老年人健康和福利的经济状况和社会行为参与者及其约400名成年子女。我们将利用家庭过渡项目，最初是作为研究农村家庭对农业经济严重衰退的反应而开始的在美国，1980年代，一直持续到今天。因此，我们处于独特的地位， COVID-19大流行对个人和家庭的影响，在30多年的背景下，积累了前瞻性数据。拟议的工作将评估与COVID-19相关的变化如何经济和社会环境影响两代人的健康和福利家庭。我们建议研究个人和家庭对经济环境的适应情况，受个人特征和生活经历影响的压力源，并提出建议关于未来增加弱势群体复原力的新方案和社会政策危机父母补助金的目标是系统地评估认知功能在一个规范的老龄化人群，并评估其与视网膜神经纤维层厚度和近端和累积经济和社会压力，并量化与血管危险因素相关的生物学变量（BMI，高血压、吸烟）以及性别，缓和了这些关联。这一补充将增强在COVID-19大流行的背景下，通过解决这些问题来实现这一目标。目标是利用补充资金解决的问题是：（1）调查COVID-19大流行对老年人及其中年子女的健康。我们将评估COVID- 19-相关的经济和社会压力因素，如经济困难和情绪困扰，受影响个人的健康状况，对既存慢性疾病的管理（例如，糖尿病），影响健康的行为（例如，吸烟、物质使用、锻炼）和认知功能。（二）调查COVID-19疫情对各代家庭福利的影响。我们将评估 COVID-19导致的经济和社会压力对社会行为和家庭的影响在几代人之间运作。在这个危机时刻，我们将研究代际经济环境、情感健康和社会行为（例如物质使用）的传播并评估COVID-19压力因素对家庭过程的影响，如婚姻和父母的质量，孩子的关系。