Archiving and harmonizing data on prevention and treatment of child traumatic stress

归档和协调有关儿童创伤应激预防和治疗的数据

• 批准号: 10195460
• 负责人: Nancy Kassam-Adams
• 金额: $ 8.8万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-03 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10195460
• 关键词: Acute; Address; Adolescent; Adult; Algorithms; Archives; Child; Child Health; Child Traumatic Stress; Code; Collaborations; Common Data Element; Communities; Data; Data Aggregation; Data Element; Data Set; Deposition; Effectiveness; Elements; Ensure; Exhibits; Exposure to; FAIR principles; Funding; Goals; Impaired health; Individual; Injury; Institutes; Intervention; Intervention Studies; Intervention Trial; Knowledge; Label; Measures; Mediator of activation protein; Medical; Meta-Analysis; Metadata; Mission; Movement; Names; National Institute of Child Health and Human Development; Nature; Outcome; Participant; Peer Review; Personal Satisfaction; Post-Traumatic Stress Disorders; Prevention; Preventive treatment; Process; Prospective Studies; Publications; Research; Research Personnel; Resources; Sample Size; Sampling; Scheme; Science; Scientific Societies; Services; Sister; Solid; Standardization; Symptoms; Trauma; Trauma recovery; Treatment Effectiveness; Underrepresented Populations; Variant; Violence; Work; archive data; archived data; data archive; data dictionary; data harmonization; data integration; data preservation; data sharing; demographic disparity; effective intervention; experience; improved; individual patient; intervention effect; maltreatment; novel; post-traumatic stress; preservation; prevent; psychological outcomes; repository; secondary analysis; syntax; tool; trauma exposure; traumatic stress; traumatized children; treatment disparity; web site

The Child Trauma Prevention and Treatment (CTPT) Data Archive will address critical barriers to using existing data to improve interventions for children impacted by traumatic experiences. Exposure to trauma is unfortunately common for children and adolescents. Each year, tens of millions around the world experience trauma; a significant proportion develop traumatic stress or related sequelae that impact child health and functioning. Recent meta-analyses have found evidence for effectiveness of some preventative and treatment interventions with traumatized children, but many questions crucial to improving these interventions (eg, moderators and mediators of effectiveness) cannot be addressed with aggregate data. Single studies have small Ns that limit statistical power and the ability to examine potential demographic disparities in treatment effectiveness. Integrative cross-study analyses using individual patient data are crucial, but hindered by enormous practical barriers (access to data, effort required for dataset integration / harmonization). The CTPT Data Archive will address these critical barriers by gathering data from intervention studies around the world with children exposed to traumas such as injury, violence, or maltreatment; applying coding and metadata to facilitate cross-study harmonization; and making data and related tools and resources accessible to researchers. Developed in conjunction with the Global Collaboration on Traumatic Stress, the project advances `FAIR data principles' – making research data more Findable, Accessible, Interoperable, and Re-usable. We leverage the solid framework provided by the Prospective studies of Acute Child Trauma and Recovery (PACT/R) archive of non-intervention studies. Our overarching objective is to build an expandable research resource for the field that will enhance the utility and value of child trauma studies - and ultimately improve child trauma interventions - by facilitating integrative cross-study analyses. The project has the following specific aims: Aim 1: Initiate CTPT Archive with data from ≥ 25 intervention studies, representing >~2000 participants; Aim 2: Apply coding and metadata for individual- and study-level data elements to facilitate harmonization Aim 3: Ensure data preservation / accessibility and promote data use We will create tools and resources (including relevant syntax and algorithms) for researchers contributing or using CTPT data and disseminate these via the childtraumadata.org website, and will deposit standardized / harmonized datasets with an established repository to ensure long-term preservation and accessibility. This project advances NICHD's goal of archiving and documenting existing datasets within its scientific mission, enabling secondary analyses by the scientific community. The CTPT archive will be an ongoing research resource, taking in data and enabling novel analyses of how and for whom child trauma interventions work, so that we can effectively address the impact of trauma on child health and well-being.

儿童创伤预防和治疗（CTPT）数据档案将解决使用的关键障碍