Archiving and harmonizing data on prevention and treatment of child traumatic stress

儿童创伤预防和治疗(CTPT)数据档案将解决使用 现有数据，以改进对受创伤经历影响的儿童的干预。暴露在创伤中是 不幸的是，这在儿童和青少年中很常见。每年，世界各地的数千万人都会经历 创伤；很大一部分人患上创伤应激或相关后遗症，影响儿童健康和 功能正常。最近的荟萃分析发现了一些预防和治疗有效的证据 对受创伤儿童的干预，但对改善这些干预措施至关重要的许多问题(例如， 效率的主持人和调解人)不能用汇总数据来处理。单项研究已经 限制统计能力和检查治疗中潜在人口统计差异的能力的小NS 有效性。使用个别患者数据的综合交叉研究分析至关重要，但受到以下因素的阻碍 巨大的实际障碍(获取数据、数据集整合/统一所需的努力)。 CTPT数据档案将通过收集干预研究的数据来解决这些关键障碍 世界各地的儿童受到伤害、暴力或虐待等创伤；应用编码 和元数据，以促进交叉研究的协调；以及制作数据和相关工具和资源 研究人员可以访问。与全球创伤应激合作组织共同开发的 该项目推进了“公平数据原则”--使研究数据更容易找到、可访问、可互操作和 可重复使用。我们利用急性儿童创伤前瞻性研究提供的坚实框架和 恢复(PACT/R)非干预研究档案。 我们的首要目标是为该领域建立一个可扩展的研究资源，以增强 儿童创伤研究的效用和价值-并最终改善儿童创伤干预-通过促进 综合交叉研究分析。该项目有以下具体目标： 目标1：使用来自≥25干预研究的数据启动CTPT档案，代表约2000名参与者； 目标2：对个人和研究层面的数据要素应用编码和元数据，以促进协调 目标3：确保数据保存/可访问性并促进数据使用 我们将创建工具和资源(包括相关的语法和算法)，供研究人员做出贡献或 使用CTPT数据，并通过儿童创伤网站传播这些数据，并将存放标准化/ 与已建立的储存库协调一致的数据集，以确保长期保存和获取。 该项目推进了NICHD在其科学领域内对现有数据集进行归档和记录的目标 任务，使科学界能够进行二次分析。CTPT档案将是一个持续的 研究资源，吸收数据，并对儿童创伤干预的方式和对象进行新的分析 工作，以便我们能够有效地解决创伤对儿童健康和福祉的影响。

The Child Trauma Prevention and Treatment (CTPT) Data Archive will address critical barriers to using existing data to improve interventions for children impacted by traumatic experiences. Exposure to trauma is unfortunately common for children and adolescents. Each year, tens of millions around the world experience trauma; a significant proportion develop traumatic stress or related sequelae that impact child health and functioning. Recent meta-analyses have found evidence for effectiveness of some preventative and treatment interventions with traumatized children, but many questions crucial to improving these interventions (eg, moderators and mediators of effectiveness) cannot be addressed with aggregate data. Single studies have small Ns that limit statistical power and the ability to examine potential demographic disparities in treatment effectiveness. Integrative cross-study analyses using individual patient data are crucial, but hindered by enormous practical barriers (access to data, effort required for dataset integration / harmonization). The CTPT Data Archive will address these critical barriers by gathering data from intervention studies around the world with children exposed to traumas such as injury, violence, or maltreatment; applying coding and metadata to facilitate cross-study harmonization; and making data and related tools and resources accessible to researchers. Developed in conjunction with the Global Collaboration on Traumatic Stress, the project advances `FAIR data principles' – making research data more Findable, Accessible, Interoperable, and Re-usable. We leverage the solid framework provided by the Prospective studies of Acute Child Trauma and Recovery (PACT/R) archive of non-intervention studies. Our overarching objective is to build an expandable research resource for the field that will enhance the utility and value of child trauma studies - and ultimately improve child trauma interventions - by facilitating integrative cross-study analyses. The project has the following specific aims: Aim 1: Initiate CTPT Archive with data from ≥ 25 intervention studies, representing >~2000 participants; Aim 2: Apply coding and metadata for individual- and study-level data elements to facilitate harmonization Aim 3: Ensure data preservation / accessibility and promote data use We will create tools and resources (including relevant syntax and algorithms) for researchers contributing or using CTPT data and disseminate these via the childtraumadata.org website, and will deposit standardized / harmonized datasets with an established repository to ensure long-term preservation and accessibility. This project advances NICHD's goal of archiving and documenting existing datasets within its scientific mission, enabling secondary analyses by the scientific community. The CTPT archive will be an ongoing research resource, taking in data and enabling novel analyses of how and for whom child trauma interventions work, so that we can effectively address the impact of trauma on child health and well-being.