Creating the Prospective studies of Acute Child Trauma and Recovery (PACT/R) Data Archive

项目总结/摘要 不幸的是，暴露于急性单一事件创伤对儿童来说很常见。伤害（非故意和 与暴力有关的）、灾害和恐怖主义以及其他潜在的创伤性事件， 年创伤暴露儿童在心理和功能适应方面表现出广泛的差异， 结果，很大一部分人会出现创伤性应激反应或其他心理后遗症， 影响儿童健康和功能。尽管绝大多数研究这些后遗症的研究都是 横截面，越来越多的前瞻性研究已经评估了儿童的适应随着时间的推移， 急性创伤暴露由于资源有限，许多前瞻性研究涉及小样本， 测量和评估时间的变化使得交叉研究比较具有挑战性。综合交叉- 使用个体患者数据的研究分析是可能的，但需要大量关注数据集整合 和数据协调，这通常超出了个别调查人员的能力范围。 我们的首要目标是为儿童创伤领域创建一个研究资源， 通过允许综合性交叉研究分析和促进使用 未来研究的共同数据元素。在拟议的R 03资助项目中，我们将利用 在现有的20个数据集和数据统一方面的相关专门知识的框架内， 急性儿童创伤和恢复（PACT/R）数据存档的前瞻性研究。PACT/R档案将 包括美国和国际前瞻性研究，数据来自至少31项研究， 来自6个国家的7000名儿童暴露于广泛的潜在创伤事件，包括伤害， 暴力和自然灾害。项目目标包括（目标1）增加至少11个新的数据集（数据来自>4000个 儿童），并建立可复制的模板，用于数据摄入和清洗，以及Meta的应用， 数据和创建一个可搜索的数据库的研究，变量和措施。(Aim（2）专家指导 咨询小组，我们将创建，应用和共享算法，用于关键变量的数据协调， 结构，以实现综合交叉研究数据分析。(Aim 3）我们将提高对PACT/R的认识 通过PACT/R网页将档案作为数据共享和二级数据分析的资源，以及（目标4） 召集一个专家咨询小组，查明数据统一方面的挑战以及现有数据中的差距 从急性儿童创伤研究，并建议共同的数据元素，为未来的前瞻性研究， 研究领域。 项目成果将促进数据共享，实现对儿童创伤前瞻性数据的二次分析， 科学界的恢复，否则是不可能的，并提高未来的价值， 通过推荐核心数据元素，在这一关键研究领域进行研究。

Project Summary / Abstract Exposure to acute single-incident trauma is unfortunately common for children. Injury (unintentional and violence-related), disasters and terrorism, and other potentially traumatic events affect millions of children each year. Trauma-exposed children exhibit a wide variation in psychological and functional adaptation and outcomes, with a significant proportion developing traumatic stress or other psychological sequelae which can impact child health and functioning. Although the vast majority of studies examining these sequelae have been cross-sectional, a growing body of prospective studies have assessed children's adaptation over time following acute trauma exposure. Due to resource limitations, many prospective studies involve small samples, and variation in measures and assessment timing make cross-study comparisons challenging. Integrative cross- study analyses using individual patient data are possible, but require substantial attention to dataset integration and data harmonization that is generally beyond the reach of individual investigators. Our overarching objective is to create a research resource for the child trauma field that will enhance the utility and value of child trauma studies by allowing integrative cross-study analyses and promoting the use of common data elements across future studies. In the proposed R03-funded project, we will leverage the solid framework of an existing set of 20 datasets and related expertise in data harmonization, to create the Prospective studies of Acute Child Trauma and Recovery (PACT/R) data archive. The PACT/R archive will include US and international prospective studies with data from at least 31 studies representing more than 7000 children from 6 countries exposed to a wide range of potentially traumatic events including injury, violence, and natural disaster. Project aims include (Aim 1) Adding at least 11 new datasets (data from >4000 children) and establishing reproducible templates for data intake and cleaning, as well as application of meta- data and creating a searchable database of studies, variables, and measures. (Aim 2) Guided by an expert advisory panel, we will create, apply, and share algorithms for data harmonization of key variables and constructs to enable integrative cross-study data analyses. (Aim 3) We will promote awareness of the PACT/R archive as a resource for data sharing and secondary data analysis via a PACT/R webpage, and (Aim 4) convene an expert advisory panel to identify challenges to data harmonization as well as gaps in available data from acute child trauma studies, and recommend common data elements for future prospective studies in this area of research. Project results will advance data sharing, enable secondary analysis of prospective data on child trauma and recovery by the scientific community that would not otherwise be possible, and enhance the value of future research in this crucial area of study by recommending core data elements.