Creating the Prospective studies of Acute Child Trauma and Recovery (PACT/R) Data Archive

项目摘要/摘要 不幸的是，暴露在急性单发创伤中对儿童来说很常见。伤害(非故意和 与暴力有关)、灾害和恐怖主义以及其他可能造成创伤的事件影响到数百万儿童 年。创伤暴露的儿童在心理和功能适应方面表现出很大的差异， 结果，相当大比例的人会出现创伤应激或其他心理后遗症 影响儿童健康和功能。尽管绝大多数研究这些后遗症的研究都是 随着时间的推移，越来越多的前瞻性研究评估了儿童的适应情况 急性创伤暴露。由于资源的限制，许多前瞻性研究涉及小样本， 衡量标准和评估时间的差异使得交叉研究比较具有挑战性。综合交叉- 使用单个患者数据进行研究分析是可能的，但需要非常注意数据集集成 以及数据协调，这通常超出个别调查人员的能力范围。 我们的首要目标是为儿童创伤领域创建一个研究资源，以提高实用价值 和儿童创伤研究的价值，允许综合交叉研究分析和促进使用 未来研究中的通用数据元素。在建议的R03资助的项目中，我们将利用 现有的20个数据集的框架和数据协调方面的相关专门知识，以创建 儿童急性创伤和康复前瞻性研究(PACT/R)数据档案。PACT/R档案将 包括美国和国际前瞻性研究，其数据来自至少31项研究，代表超过 来自6个国家的7000名儿童暴露在包括受伤在内的各种潜在创伤性事件中， 暴力和自然灾害。项目目标包括(目标1)添加至少11个新数据集(数据来自&gt；4000 儿童)，并建立可复制的模板，用于数据获取和清理以及元数据的应用 数据，并创建一个可搜索的研究、变量和测量数据库。(目标2)由专家指导 咨询小组，我们将创建、应用和共享关键变量和数据协调的算法 构建以实现综合交叉研究数据分析。(目标3)我们将提高对PACT/R的认识 通过PACT/R网页将档案作为数据共享和二级数据分析的资源，以及(目标4) 召集一个专家咨询小组，以确定数据协调方面的挑战以及现有数据中的差距 来自急性儿童创伤研究，并为未来的前瞻性研究推荐通用的数据元素 研究领域。 项目成果将促进数据共享，实现对儿童创伤预期数据的二次分析，并 科学界的复苏，否则是不可能的，并增强了未来的价值 通过推荐核心数据元素来研究这一关键研究领域。

Project Summary / Abstract Exposure to acute single-incident trauma is unfortunately common for children. Injury (unintentional and violence-related), disasters and terrorism, and other potentially traumatic events affect millions of children each year. Trauma-exposed children exhibit a wide variation in psychological and functional adaptation and outcomes, with a significant proportion developing traumatic stress or other psychological sequelae which can impact child health and functioning. Although the vast majority of studies examining these sequelae have been cross-sectional, a growing body of prospective studies have assessed children's adaptation over time following acute trauma exposure. Due to resource limitations, many prospective studies involve small samples, and variation in measures and assessment timing make cross-study comparisons challenging. Integrative cross- study analyses using individual patient data are possible, but require substantial attention to dataset integration and data harmonization that is generally beyond the reach of individual investigators. Our overarching objective is to create a research resource for the child trauma field that will enhance the utility and value of child trauma studies by allowing integrative cross-study analyses and promoting the use of common data elements across future studies. In the proposed R03-funded project, we will leverage the solid framework of an existing set of 20 datasets and related expertise in data harmonization, to create the Prospective studies of Acute Child Trauma and Recovery (PACT/R) data archive. The PACT/R archive will include US and international prospective studies with data from at least 31 studies representing more than 7000 children from 6 countries exposed to a wide range of potentially traumatic events including injury, violence, and natural disaster. Project aims include (Aim 1) Adding at least 11 new datasets (data from >4000 children) and establishing reproducible templates for data intake and cleaning, as well as application of meta- data and creating a searchable database of studies, variables, and measures. (Aim 2) Guided by an expert advisory panel, we will create, apply, and share algorithms for data harmonization of key variables and constructs to enable integrative cross-study data analyses. (Aim 3) We will promote awareness of the PACT/R archive as a resource for data sharing and secondary data analysis via a PACT/R webpage, and (Aim 4) convene an expert advisory panel to identify challenges to data harmonization as well as gaps in available data from acute child trauma studies, and recommend common data elements for future prospective studies in this area of research. Project results will advance data sharing, enable secondary analysis of prospective data on child trauma and recovery by the scientific community that would not otherwise be possible, and enhance the value of future research in this crucial area of study by recommending core data elements.