CPS: Autonomous Attainment of Tissue-Centricity in Electrosurgery through Data-Driven Persistently Evolving Thermogeometric Adaptivity

CPS：通过数据驱动的持续发展的热几何适应性在电外科中自主实现以组织为中心

• 批准号: 10202599
• 负责人: Joseph Bentsman
• 金额: $ 32.49万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-20 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10202599
• 关键词: Algorithms; Anesthetics; Awareness; Biological Sciences; Burn injury; Caring; Coagulation Process; Computer software; Data; Electrodes; Electrosurgery; Engineering; Excision; Hemostatic function; Individual; Injury; Malignant - descriptor; Medical; Mission; Necrosis; Operative Surgical Procedures; Patients; Regulation; Research Design; Research Methodology; Robotics; Salvelinus; Sepsis; Stream; Structure; Surgeon; Techniques; Test Result; Time; Tissue Model; Tissues; Vision; Visual; adverse outcome; base; cost; cyber physical; design; flexibility; improved; mortality; multimodality; novel; sensor; software development; surgery outcome; tool; voltage

1. The Main Project Objective. Electrosurgery has become the leading surgical technique due to its low cost, adaptability, and capability for simultaneous cutting and hemostasis. However, at present surgeon maintains fixed mode and power level, routinely exceeding the required minimum. This gives rise to tissue charring, necrosis, and excessive voltage prone to cause injuries. The broad objective of this project is to mitigate the adverse consequences of a priori fixing mode/power, especially in laparoscopic and robotic setting, through enabling a paradigm shift - from surgeon-centric to tissue-centric. The latter consists in adaptively optimizing the actual operating conditions for maximum tissue benefit, while autonomously transitioning between modes, instead of holding the preset cut, mixed, or coagulation mode and its power. 2. Specific Aims. To enable the novel paradigm, specific aims consist in 1) developing i) multiscale control/display-oriented surgically-relevant tissue models through mutually reinforced first-principles and Al/data-driven formalisms, ii) multimodal software-sensor-based tissue-centric sensing, and iii) multiscale network adaptive tissue-centric control algorithms; 2) integrating them into a coherent cyber-physical design paradigm and constructing, on its basis, a multifunctional electrosurgical tool; 3) enabling a tissue-aware operating surgeon interface via real-time visual tissue status streaming, and 4) extensively testing resulting electrosurgical setting on perfused tissue . 3. Relevance to BIMIT Mission. The project integrates physical, engineering, and life sciences to improve medical care through developing electrosurgical paradigm for maximum tissue/patient benefit. 4. Research Design and Methods. 1) advance precarbonization sensing both fundamentally and technically, 2) design and implement a real-time multi-modal (thermal/vision/spectroscopic) sensor array that characterizes onset of the tissue condition corresponding to each of the modes, 3) in place of a single monopolar probe, design and build a fused array of flexible isolated electrodes to form a reconfigurable multi-arcing spatially-mixed-mode thermogeometric footprint, 4) develop software to aggregate fused probe and multi-modal sensor array into a hierarchical evolving structure to deliver the real-time-optimized thermogeometrically adaptable electrosurgical footprint through closed-loop individual mode selection /power regulation in each microprobe, 5) develop software for tissue-aware surgeon interface.

1. 项目的主要目标。电外科手术因其低成本而成为外科手术的主导技术

项目成果

SPATIAL BEHAVIOUR OF SOLUTIONS OF THE MOORE-GIBSON-THOMPSON EQUATION.

Moore-Gibson-Thompson 方程解的空间行为。

• DOI: 10.1007/s00021-021-00629-4
• 发表时间: 2021
• 期刊: Journal of mathematical fluid mechanics : JMFM
• 作者: Ostoja-Starzewski,M;Quintanilla,R
• 通讯作者: Quintanilla,R

PDE-Based Modeling and Non-collocated Feedback Control of Electrosurgical-Probe/Tissue Interaction.

• DOI: 10.23919/acc50511.2021.9483240
• 发表时间: 2021-05
• 期刊: Proceedings of the ... American Control Conference. American Control Conference
• 作者: El-Kebir H;Bentsman J
• 通讯作者: Bentsman J

Averaging of turbulent micropolar media: turbulent couple-stress, heat flux, and energy.

湍流微极性介质的平均值：湍流偶应力、热通量和能量。

• DOI: 10.1007/s00033-021-01500-2
• 发表时间: 2021
• 期刊: Zeitschrift fuer angewandte mathematik und physik
• 作者: Ostoja-Starzewski,Martin

GaN-HEMT Based Very-High-Frequency AC Power Supply for Electrosurgery.

• DOI: 10.1109/apec42165.2021.9487352
• 发表时间: 2021-06
• 期刊: Conference proceedings. IEEE Applied Power Electronics Conference and Exposition
• 作者: Bao, Congbo;Mazumder, Sudip K.
• 通讯作者: Mazumder, Sudip K.

Spontaneous Negative Entropy Increments in Granular Flows.

颗粒流中的自发负熵增量。

• DOI: 10.1115/1.4049184
• 发表时间: 2021
• 期刊: Journal of applied mechanics
• 作者: Laudani,Rossella;Ostoja-Starzewski,Martin
• 通讯作者: Ostoja-Starzewski,Martin