U.S. Deprescribing Research Network

项目摘要/摘要 取消处方--停止不必要的、潜在的有害的或目标不一致的有组织的过程 以安全、有效和以患者为中心的方式进行药物治疗--对改善健康大有可为 以及老年人的福祉。然而，关于停药的研究是相当新的，还有很多重要的工作要做 要做的事。为了解决这一差距，我们建议建立一个非处方研究网络，该网络将催化 对停药进行有影响力的研究，并建立一个从事这方面工作的跨学科调查社区 菲尔德。我们将使用两种互补的方法来实现这一点。首先，我们将建立一系列专注于 关于调查员发展、利益相关者参与、数据和资源以及试点和探索性 研究，以及一个领导和管理核心，将监督全面的网络活动。这些 CORE将提供有关学习、协作、研究人员开发和试点的服务和支持 资金问题。这些活动将提高调查人员进行高质量、跨学科和 利益相关者知情的研究在停药方面，并成功竞争未来的资金。第二，我们 将召开一系列特别项目，分成4个工作组。这些项目将使用 将原创研究和协商一致进程结合起来，在各领域发展新的科学和基础设施 这对于推进老年人的停药研究至关重要。每一项活动都将重点放在 老年人，特别是那些患有多种慢性病和其他脆弱来源的人，以及 网络将牢牢植根于老龄研究和老年病学的原则。 与上述目标一致，我们有6个具体目标。它们是：(1)发展一个全国性的社区 研究人员对取消处方感兴趣，并支持相互学习和合作机会 将扩大非处方研究的质量、数量和翻译影响；(2)创建 协调的研究地点网络，将产生科学，解决后勤和安全挑战，以及 发展基础设施，以进行有关停药的临床研究；。(3)发展及发放资源。 帮助研究人员克服停药研究中的常见挑战，并最大限度地提高科学研究的 奖学金在这一领域的有效性和影响；(4)支持针对高优先事项的创新性先导研究 取消处方方面的主题，并将促进未来的调查员发展和更大规模的项目；(5) 让广泛的利益相关者参与，以最大限度地提高以下项目的相关性、可持续性和传播潜力 关于非处方的研究；及(6)将网络的工作和结果广泛传播给 并与其他组织和研究网络协调我们的努力。

PROJECT SUMMARY / ABSTRACT Deprescribing - the structured process of stopping unnecessary, potentially harmful, or goal-discordant medications in a safe, effective, and patient-centered manner – holds great promise for improving the health and well-being of older adults. Yet, research on deprescribing is fairly new, and much important work remains to be done. To address this gap, we propose to establish a deprescribing research network that will catalyze impactful research on deprescribing and build an interdisciplinary community of investigators working in this field. We will achieve this using 2 complementary approaches. First, we will establish a series of cores focused on Investigator Development, Stakeholder Engagement, Data and Resources, and Pilot and Exploratory Studies, and a Leadership and Administration Core that will oversee the full range of network activities. These cores will provide services and supports around learning, collaboration, investigator development, and pilot funding. These activities will enhance investigators' abilities to conduct high-quality, interdisciplinary, and stakeholder-informed research in deprescribing, and to compete successfully for future funding. Second, we will convene a series of special projects, organized into 4 Working Groups. These projects will use a combination of original research and consensus processes to develop new science and infrastructure in areas that are critical for advancing deprescribing research for older adults. Each of these activities will focus on older adults, particularly those with multiple chronic conditions and other sources of vulnerability, and the network will be firmly rooted in the principles of aging research and geriatrics. Consistent with the above goals, we have 6 specific aims. They are: (1) To develop a national community of investigators interested in deprescribing and to support mutual learning and opportunities for collaboration that will expand the quality, quantity, and translational impact of deprescribing research; (2) To create a coordinated network of research sites that will generate science, address logistical and safety challenges, and develop infrastructure to conduct clinical studies on deprescribing; (3) To develop and disseminate resources to help investigators overcome common challenges in deprescribing research and maximize the scientific validity and impact of scholarship in this area; (4) To support innovative pilot studies that address high-priority topics in deprescribing and will catalyze future investigator development and larger-scale projects; (5) To engage a broad range of stakeholders to maximize the relevance, sustainability, and dissemination potential of research on deprescribing; and (6) To disseminate the work and findings of the network to a broad range of external stakeholders and coordinate our efforts with other organizations and research networks.