U.S. Deprescribing Research Network

项目概要/摘要 取消处方-停止不必要的，潜在有害的或目标不一致的结构化过程 以安全、有效和以患者为中心的方式使用药物-为改善健康带来了巨大的希望。 和老年人的福祉。然而，关于取消处方的研究是相当新的，还有许多重要的工作要做 要做的事。为了解决这一差距，我们建议建立一个取消处方的研究网络， 对取消处方进行有影响力的研究，并建立一个跨学科的研究人员社区， 领域我们将使用两种互补的方法来实现这一目标。首先，我们将建立一系列核心， 关于研究者发展、利益相关者参与、数据和资源以及试点和探索性 研究，以及领导和管理核心，将监督网络活动的全方位。这些 核心小组将围绕学习、协作、研究者发展和试点提供服务和支持 经费这些活动将提高调查人员进行高质量、跨学科和 在取消处方方面进行知情的研究，并成功地竞争未来的资金。二是 将召开一系列特别项目，分为4个工作组。这些项目将使用 结合原创性研究和共识过程，在以下领域开发新的科学和基础设施： 这对于推进老年人的非处方研究至关重要。每项活动都将侧重于 老年人，特别是患有多种慢性疾病和其他脆弱性来源的老年人， 该网络将牢牢扎根于老龄化研究和老年医学的原则。 与上述目标相一致，我们有6个具体目标。（1）建立一个国家社区， 有兴趣取消处方的研究者，并支持相互学习和合作的机会， 将扩大质量，数量，以及取消处方研究的转化影响;（2）创建一个 协调的研究地点网络，将产生科学，解决后勤和安全挑战， 发展基础设施，以进行有关取消处方的临床研究;（3）发展及发放资源 帮助研究人员克服取消研究处方的共同挑战， 有效性和影响的奖学金在这一领域;（4）支持创新的试点研究，解决高度优先事项 主题，并将促进未来的研究者发展和更大规模的项目;（5） 让广泛的利益相关者参与进来，最大限度地发挥相关性、可持续性和传播潜力， 研究取消处方;及（6）向多个不同界别的人士宣传该网络的工作及研究结果， 外部利益相关者，并与其他组织和研究网络协调我们的努力。

PROJECT SUMMARY / ABSTRACT Deprescribing - the structured process of stopping unnecessary, potentially harmful, or goal-discordant medications in a safe, effective, and patient-centered manner – holds great promise for improving the health and well-being of older adults. Yet, research on deprescribing is fairly new, and much important work remains to be done. To address this gap, we propose to establish a deprescribing research network that will catalyze impactful research on deprescribing and build an interdisciplinary community of investigators working in this field. We will achieve this using 2 complementary approaches. First, we will establish a series of cores focused on Investigator Development, Stakeholder Engagement, Data and Resources, and Pilot and Exploratory Studies, and a Leadership and Administration Core that will oversee the full range of network activities. These cores will provide services and supports around learning, collaboration, investigator development, and pilot funding. These activities will enhance investigators' abilities to conduct high-quality, interdisciplinary, and stakeholder-informed research in deprescribing, and to compete successfully for future funding. Second, we will convene a series of special projects, organized into 4 Working Groups. These projects will use a combination of original research and consensus processes to develop new science and infrastructure in areas that are critical for advancing deprescribing research for older adults. Each of these activities will focus on older adults, particularly those with multiple chronic conditions and other sources of vulnerability, and the network will be firmly rooted in the principles of aging research and geriatrics. Consistent with the above goals, we have 6 specific aims. They are: (1) To develop a national community of investigators interested in deprescribing and to support mutual learning and opportunities for collaboration that will expand the quality, quantity, and translational impact of deprescribing research; (2) To create a coordinated network of research sites that will generate science, address logistical and safety challenges, and develop infrastructure to conduct clinical studies on deprescribing; (3) To develop and disseminate resources to help investigators overcome common challenges in deprescribing research and maximize the scientific validity and impact of scholarship in this area; (4) To support innovative pilot studies that address high-priority topics in deprescribing and will catalyze future investigator development and larger-scale projects; (5) To engage a broad range of stakeholders to maximize the relevance, sustainability, and dissemination potential of research on deprescribing; and (6) To disseminate the work and findings of the network to a broad range of external stakeholders and coordinate our efforts with other organizations and research networks.