Chemistry and Biology Interface (CBI) NIH T32 Training Grant

化学-生物学接口(CBI)博士前课程的目标是提供跨学科的 培养具有不同兴趣的有才华的学生，使他们能够应用机械和原子论 从化学的角度看待重要的生物问题。该项目汇集了来自世界各地的42名教师培训人员 大学里有八个学术单位。特拉华州代表有机化学、分析 化学、生物化学、化学生物学、结构生物学、分子生物学、细胞生物学、系统生物学、 生物信息学、分子生物学、细胞生物学、微生物学、病毒学和发育生物学。教职员工 培训者包括在生物分子科学方面拥有活跃研究计划的新老研究人员。 和培养研究生的经验。多样化的实习生群体(重点是招聘和留住城市管理人员) 具有不同教育背景的人是根据他们探索多学科的愿望而被选中的 化学和生物交界处的问题，他们的GRE成绩，本科GPA，字母 推荐和研究背景。每年通过现有毕业生录取8名实习生 化学与生物化学、化学与生物分子工程、生物科学或其他专业 CBI培训师部门和大学为他们的第一年提供了支持。第二条由资金资助的录取轨道 CBI计划概述；学生对化学和生物交界处的研究有浓厚兴趣 将被邀请在他们研究生学习的第一年或第二年结束时申请。所有实习生都会满意 除了对CBI的要求外，对其特定系课程的学位要求 程序。三门一学期的课程将从六门不同的课程列表中挑选出来 各部门。CBI计划的一个关键特点是每个受训人员承诺提供的实验室轮换 他们拥有不同学科的实践经验。在课程和实验室轮换之间学生 预计将接触到从原子论到细胞学的概念和方法。学生们 在这一背景下，能够创造性地思考与以下方面有关的生物和化学问题 人类健康。这项提议旨在为学生提供一份由大学资助的实习(当地 制药/生物技术公司、国家实验室和新的合作伙伴，以促进他们的职业发展。全 学员被要求参加一系列季度负责任的研究行为(RCR)研讨会，a 为期两天的大学赞助了RCR和1月份关于数据重复性和严密性的研讨会。每周一次的研讨会 系列将CBI社区聚集在一起，为学员提供了无数展示他们自己的机会 工作，以及从教员培训人员和外部演讲者那里学习。每个实习生都要进行一次密集的 独立研究经验，最终发表一篇论文，代表对某一领域的原创贡献 化学-生物界面。该计划遵循并建立在成功的25年培训模式基础上 既有广博的科学知识，又有选定核心学科扎实基础的科学家。

The objective of this Chemistry-Biology Interface (CBI) Predoctoral Program is to provide cross-disciplinary training to talented students with diverse interests that will enable them to apply the mechanistic and atomistic perspective of chemistry to important biological problems. The program brings together 42 faculty trainers from eight academic units at the Univ. of Delaware representing disciplines of organic chemistry, analytical chemistry, biochemistry, chemical biology, structural biology, molecular biology, cell biology, systems biology, bioinformatics, molecular biology, cell biology, microbiology, virology, and developmental biology. The faculty trainers include both new and established researchers with vibrant research programs in biomolecular science and experience in training graduate students. A diverse trainee group (with a focus to recruit and retain URMs) with varied educational backgrounds are selected on the basis of their desire to explore multidisciplinary problems at the interface of chemistry and biology, their GRE scores, undergraduate GPA, letters of recommendation and research background. Eight trainees are admitted each year through existing graduate programs of Chemistry & Biochemistry, Chemical & Biomolecular Engineering, Biological Sciences or other CBI trainer departments and university supported for their first year. A second, funded track of admission to the CBI program is outlined; students with a strong interest in research at the interface of chemistry and biology will be invited to apply at the end of their first or second year of their graduate studies. All trainees will satisfy the degree requirements for their specific departmental program in addition to the requirements for the CBI program. Three one semester courses will be selected from a diverse list of course offerings from six departments. A key feature of the CBI program is the laboratory rotations each trainee undertakes to provide them with hands-on experience in the different disciplines. Between courses and laboratory rotations students are expected to have exposure to concepts and methods from the atomistic to the cellular. Students are empowered by this background to think creatively about biological and chemical problems that are relevant to human health. This proposal aims to provide students with a menu of university funded internships (local pharmaceutical/biotech firms, National Labs and new collaborations to enhance their career development. All trainees are required to participate in a series of quarterly responsible conduct of research (RCR) workshops, a 2-day University sponsored RCR and a January workshop of data reproducibility and rigor. A weekly seminar series brings the CBI community together and provides trainees numerous opportunities to present their own work, as well as learn from both faculty trainers and outside speakers. Each trainee undertakes an intensive independent research experience culminating in a dissertation representing an original contribution to a field at the chemistry-biology interface. This program follows and builds on a successful 25-year model for training scientists with both broad scientific knowledge as well as solid foundations in a chosen core discipline.