NIH Training Grant in Chemistry-Biology Interface

项目摘要：该化学-生物界面(CBI)培训计划的目标是准备10 博士前学生将成为生物医学科学领域的下一代科学家。这个目标将是 通过招收顶尖学生并培训他们进行跨学科研究、批判性思维、 写作和沟通，严格的实验设计和解释，以及负责任的行为 研究。该计划的其他独特部分包括：a)CBI的尖端研究课程，b) 关于创业、知识产权管理和联网的讲习班，以及c)参加 同行主导的团队学习(PLTL)经验，这将进一步丰富技能集和专业准备 实习生的名单。该计划将直接受益于密切的研究关系和物理上的接近 艺术、科学和工程(AS&E)和医学与牙科学院(SMD)在 罗切斯特大学及其在科技创新和创业翻译方面的既定记录 新业务的发现。该计划包括从六名优秀教官中选出的27名优秀教官 A&E和SMD内的部门，所有这些部门都有良好的部门内和部门间记录 研究和指导活动中的互动。该研究分享了该项目的一个中心主题 导师的利益，就是发展基本知识和战略，以支持 产生、开发和交付新的治疗药物和方法，用于预防和治疗 人类疾病的治疗。受训者将围绕这一统一的四个主要领域之一进行研究 主题：合成化学、药物发现和传递、药物靶标识别和传感以及结构 以及生物分子和生物材料的功能。项目主任和两名副主任将由 一个由三名额外教员组成的指导委员会。CBI的实习生将从 参与部门中最优秀的学生，特别强调扩大受训人员的多样性 通过外展活动，招募不同的申请者，留住和培养学生 程序。新的CBI实习生将从研究生学习的第二年开始，并将参加核心CBI 一门关于负责任的研究行为的课程，一门关于有效写作和沟通的课程。 所有受训人员都将参加和参与一系列由CBI赞助的丰富和协同活动， 包括专业发展研讨会、年度静修和每月CBI午餐。在他们的第四年 博士课程，学员将担任PLTL研讨会的CBI课程的负责人，继续专业 发展，并在CBI务虚会上发表演讲。受训者还将完成并为他们的论文辩护 由加州调查局的一名教官监督。预计完成该课程的学生将是 在生命和生物医学科学领域从事各种职业的准备非常充分。在这方面取得了成功 该计划还将取决于学员的多样性和申请者人数的增加。

PROJECT SUMMARY: The goal of this Chemistry-Biology Interface (CBI) training program is to prepare 10 predoctoral students to become next-generation scientists in the biomedical sciences. This goal will be achieved through recruiting top students and training them in cross-disciplinary research, critical thinking, writing and communication, rigorous experiment design and interpretation, and responsible conduct of research. Other distinctive components of the program are: a) a course on cutting-edge research at the CBI, b) workshops on entrepreneurship, intellectual property management, and networking, and c) participation in Peer-Led Team Learning (PLTL) experiences, which will further enrich the skillset and professional preparation of the trainees. The program will directly benefit from the close research relationship and physical proximity between Arts, Sciences, & Engineering (AS&E) and the School of Medicine and Dentistry (SMD) at the University of Rochester, and its established record in innovation and entrepreneurial translation of scientific discoveries into new businesses. The program includes 27 outstanding preceptors selected from six departments within AS&E and SMD, all of whom have a strong record of intra- and interdepartmental interactions in research and mentoring activities. A central theme of the program, as shared by the research interests of the preceptors, is the development of fundamental knowledge and strategies to support the generation, development, and delivery of new therapeutic agents and modalities for the prevention and treatment of human diseases. Trainees will conduct research in one of the four main areas around this unifying theme: Synthetic Chemistry, Drug Discovery & Delivery, Drug Target Identification and Sensing, and Structure and Function of Biomolecules & Biomaterials. The Program Director and two Deputy Directors will be aided by a Steering Committee comprising three additional faculty members. The CBI trainees will be drawn from the strongest students in the participating departments, with a particular emphasis on expanding trainee diversity through outreach activities, recruiting a diverse pool of applicants, and retaining and nurturing students in the program. New CBI trainees will start in Year 2 of their graduate studies and will participate in the core CBI courses, a course on responsible conduct of research, and a course on effective writing and communication. All trainees will participate and contribute to a host of CBI-sponsored enrichment and synergistic activities, including professional development workshops, an annual retreat, and monthly CBI lunches. In Year 4 of their PhD program, trainees will serve as PLTL workshop leaders for CBI courses, continue in professional development, and present a talk at the CBI retreat. Trainees also will complete and defend their theses supervised by one of the CBI preceptors. It is expected that students completing this program will be exceptionally well prepared to pursue a variety of careers in the life and biomedical sciences. Success in this program will also be determined by increased diversity of trainees and in the pool of applicants.