NIH Training Grant in Chemistry-Biology Interface

项目摘要：该化学-生物界面 (CBI) 培训计划的目标是准备 10 博士前学生成为生物医学领域的下一代科学家。这个目标将是 通过招募顶尖学生并对他们进行跨学科研究、批判性思维、 写作和沟通，严格的实验设计和解释，以及负责任的行为 研究。该计划的其他独特组成部分是：a）CBI 前沿研究课程，b） 关于创业、知识产权管理和网络的研讨会，以及 c) 参与 同伴主导的团队学习 (PLTL) 经验，将进一步丰富技能和专业准备 的实习生。该计划将直接受益于密切的研究关系和地理位置的接近 艺术、科学和工程 (AS&E) 与医学和牙科学院 (SMD) 之间的合作 罗切斯特大学及其在科技创新和创业翻译方面的良好记录 新业务的发现。该计划包括从六位杰出导师中选出的 27 名 AS&E 和 SMD 内的部门，所有这些部门都有良好的部门内和跨部门记录 研究和指导活动中的互动。研究共享的该计划的中心主题 导师的兴趣在于发展基础知识和策略来支持 产生、开发和提供新的治疗剂和预防和治疗方式 治疗人类疾病。学员将围绕这一统一在四个主要领域之一进行研究 主题：合成化学、药物发现与递送、药物靶点识别与传感、结构 以及生物分子和生物材料的功能。项目主任和两名副主任将得到以下人员的协助 由另外三名教职人员组成的指导委员会。 CBI 学员将从 参与部门中最优秀的学生，特别强调扩大实习生的多样性 通过外展活动，招募多元化的申请者，并留住和培养学生 程序。新的 CBI 学员将从研究生学习的第二年开始，并将参加核心 CBI 课程，一门关于负责任的研究行为的课程，以及一门关于有效写作和沟通的课程。 所有学员都将参加 CBI 赞助的一系列丰富和协同活动并做出贡献， 包括专业发展研讨会、年度静修会和每月 CBI 午餐会。在他们的第四年 博士课程，学员将担任CBI课程的PLTL研讨会负责人，继续专业学习 开发，并在 CBI 务虚会上发表演讲。学员还将完成并答辩他们的论文 由一位 CBI 导师监督。预计完成该课程的学生将 为从事生命和生物医学科学领域的各种职业做好了充分准备。在这方面取得成功 计划还将根据受训者和申请人库的多样性的增加来确定。

PROJECT SUMMARY: The goal of this Chemistry-Biology Interface (CBI) training program is to prepare 10 predoctoral students to become next-generation scientists in the biomedical sciences. This goal will be achieved through recruiting top students and training them in cross-disciplinary research, critical thinking, writing and communication, rigorous experiment design and interpretation, and responsible conduct of research. Other distinctive components of the program are: a) a course on cutting-edge research at the CBI, b) workshops on entrepreneurship, intellectual property management, and networking, and c) participation in Peer-Led Team Learning (PLTL) experiences, which will further enrich the skillset and professional preparation of the trainees. The program will directly benefit from the close research relationship and physical proximity between Arts, Sciences, & Engineering (AS&E) and the School of Medicine and Dentistry (SMD) at the University of Rochester, and its established record in innovation and entrepreneurial translation of scientific discoveries into new businesses. The program includes 27 outstanding preceptors selected from six departments within AS&E and SMD, all of whom have a strong record of intra- and interdepartmental interactions in research and mentoring activities. A central theme of the program, as shared by the research interests of the preceptors, is the development of fundamental knowledge and strategies to support the generation, development, and delivery of new therapeutic agents and modalities for the prevention and treatment of human diseases. Trainees will conduct research in one of the four main areas around this unifying theme: Synthetic Chemistry, Drug Discovery & Delivery, Drug Target Identification and Sensing, and Structure and Function of Biomolecules & Biomaterials. The Program Director and two Deputy Directors will be aided by a Steering Committee comprising three additional faculty members. The CBI trainees will be drawn from the strongest students in the participating departments, with a particular emphasis on expanding trainee diversity through outreach activities, recruiting a diverse pool of applicants, and retaining and nurturing students in the program. New CBI trainees will start in Year 2 of their graduate studies and will participate in the core CBI courses, a course on responsible conduct of research, and a course on effective writing and communication. All trainees will participate and contribute to a host of CBI-sponsored enrichment and synergistic activities, including professional development workshops, an annual retreat, and monthly CBI lunches. In Year 4 of their PhD program, trainees will serve as PLTL workshop leaders for CBI courses, continue in professional development, and present a talk at the CBI retreat. Trainees also will complete and defend their theses supervised by one of the CBI preceptors. It is expected that students completing this program will be exceptionally well prepared to pursue a variety of careers in the life and biomedical sciences. Success in this program will also be determined by increased diversity of trainees and in the pool of applicants.