Research Training in Pediatric Non-Malignant Hematology

儿科非恶性血液学研究培训

• 批准号: 10201726
• 负责人: Clinton H Joiner
• 金额: $ 24.79万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10201726
• 关键词: Childhood; Hematology; Non-Malignant; Research Training

This new T32 training grant addresses the crucial need for programs to train physician scientists and clinical investigators in pediatric non-malignant hematology. Research in hematology – particularly in pediatrics – has elucidated many of the genetic, cellular and molecular mechanisms underlying disease processes, as well as fundamental cellular functions such as cell differentiation and gene regulation. Yet despite the many scientific and clinical advances in hematology over the past decades, the number of investigators funded by NIH for hematology related research has steadily declined since 2002. The Hematology Training Program (HTP) supported by this T32 will offer rigorous training in basic/translational research to postdoctoral MD, MD/PhD and PhD fellows, under the mentorship of 28 faculty mentors supported by $25.7 M in extramural funding ($17.3 from Federal sources). At Emory University, established research programs in sickle cell disease, hemostasis and thrombosis, hematopoiesis and stem cell biology, gene therapy, and red cell physiology and transfusion medicine are embedded in the largest clinical program in pediatric hematology in the country, providing huge patient volumes for clinical and translational research within Children's Healthcare of Atlanta. Partnerships with the Georgia Institute of Technology and Morehouse School of Medicine broaden the faculty mentor pool. Each trainee will have a laboratory research Mentor and a clinical Co-mentor to foster basic or translational research relevant to pediatric hematology. Pairing of senior mentors with junior mentors from a pool of 11 young faculty members will expand the supply of future mentors. Integrated into the highly successful Pediatric Hematology/Oncology/Bone Marrow Transplant (BMT) Fellowship Program of the Aflac Cancer and Blood Disorders Center, the new HTP will admit 2 fellows each year for 2 years of support, training 5-7 MD fellows and 3-5 PhD postdoctoral fellows over 5 years. Candidates will be MD, MD/PhD and PhD fellows within the Fellowship Training Program and associated laboratories, as well as external candidates chosen on the basis of their prior training and research accomplishments, academic potential, and commitment to research in non-malignant hematology. In addition to rigorous laboratory research training, trainees will participate in a course in conduct of ethical research, departmental career development seminars, grant writing and academic skills training, research conferences, journal clubs, and fellowship program research retreats. Individual Training Plans will be developed for each trainee and progress will be monitored by a multidisciplinary scholarship oversight committees. Trainees will present their work at national meetings and develop applications for career development (K-type) awards. The HTP will take advantage of the extensive research resources of Emory University, including formal course work and degree programs in clinical and translational research available through Emory's CTSA program. Establishment of this program will allow us to train the next generation of academic leaders in pediatric non-malignant hematology.

这一新的T32培训拨款满足了培训内科科学家和临床医生的计划的迫切需要 儿科非恶性血液学研究人员。血液学研究--尤其是儿科研究-- 还阐明了许多潜在疾病过程的遗传、细胞和分子机制 作为细胞分化和基因调控等基本细胞功能。然而，尽管有许多 在过去的几十年里，血液学的科学和临床进展，资助的研究人员的数量 自2002年以来，NIH用于血液学相关研究的人数一直在稳步下降。血液学培训计划 (HTP)由本T32支持，将为博士后医学博士提供严格的基础/翻译研究培训， 博士/博士和博士研究员，在28名教师导师的指导下，得到2570万美元的校外资金支持 资金(1730万美元来自联邦来源)。在埃默里大学，建立了镰状细胞的研究项目 疾病、止血和血栓形成、造血和干细胞生物学、基因治疗和红细胞 生理学和输血医学是儿科血液学最大的临床课程。 在中国，为儿童医院的临床和转化研究提供大量的患者 亚特兰大医疗保健公司。与佐治亚理工学院和莫尔豪斯学院 医学部扩大了教师辅导员队伍。每个实习生将有一名实验室研究导师和一名临床 共同指导，促进与儿科血液学相关的基础或转化性研究。高级导师的配对 有了11名年轻教职员工中的初级导师，将扩大未来导师的供应。 整合到非常成功的儿童血液/肿瘤/骨髓移植(BMT)中 Aflac癌症和血液疾病中心的奖学金计划，新的HTP将每人接纳2名研究员 为期2年的支持，在5年内培训5-7名医学博士研究员和3-5名博士后研究员。候选人 将是研究员培训计划和相关实验室的医学博士、医学博士和博士研究员，如 以及根据其先前的培训和研究成就挑选的外部候选人， 学术潜力，并致力于非恶性血液学的研究。除了严谨的 实验室研究培训，学员将参加一个伦理学研究的课程，系 职业发展研讨会、助学金撰写和学术技能培训、研究会议、期刊俱乐部、 奖学金项目的研究也在撤退。将为每个受训人员制定个人培训计划，并 进展将由多学科奖学金监督委员会监督。实习生将展示他们的 在国家会议上工作，开发职业发展(K型)奖项的申请。HTP将需要 利用埃默里大学广泛的研究资源，包括正规课程和学位 通过Emory的CTSA计划提供的临床和转化研究计划。设立这个机构 该计划将使我们能够培养下一代儿科非恶性血液学方面的学术领袖。