Research Training in Pediatric Non-Malignant Hematology

儿科非恶性血液学研究培训

• 批准号: 10472492
• 负责人: Clinton H Joiner
• 金额: $ 18.93万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10472492
• 关键词: Childhood; Hematology; Non-Malignant; Research Training

This new T32 training grant addresses the crucial need for programs to train physician scientists and clinical investigators in pediatric non-malignant hematology. Research in hematology – particularly in pediatrics – has elucidated many of the genetic, cellular and molecular mechanisms underlying disease processes, as well as fundamental cellular functions such as cell differentiation and gene regulation. Yet despite the many scientific and clinical advances in hematology over the past decades, the number of investigators funded by NIH for hematology related research has steadily declined since 2002. The Hematology Training Program (HTP) supported by this T32 will offer rigorous training in basic/translational research to postdoctoral MD, MD/PhD and PhD fellows, under the mentorship of 28 faculty mentors supported by $25.7 M in extramural funding ($17.3 from Federal sources). At Emory University, established research programs in sickle cell disease, hemostasis and thrombosis, hematopoiesis and stem cell biology, gene therapy, and red cell physiology and transfusion medicine are embedded in the largest clinical program in pediatric hematology in the country, providing huge patient volumes for clinical and translational research within Children's Healthcare of Atlanta. Partnerships with the Georgia Institute of Technology and Morehouse School of Medicine broaden the faculty mentor pool. Each trainee will have a laboratory research Mentor and a clinical Co-mentor to foster basic or translational research relevant to pediatric hematology. Pairing of senior mentors with junior mentors from a pool of 11 young faculty members will expand the supply of future mentors. Integrated into the highly successful Pediatric Hematology/Oncology/Bone Marrow Transplant (BMT) Fellowship Program of the Aflac Cancer and Blood Disorders Center, the new HTP will admit 2 fellows each year for 2 years of support, training 5-7 MD fellows and 3-5 PhD postdoctoral fellows over 5 years. Candidates will be MD, MD/PhD and PhD fellows within the Fellowship Training Program and associated laboratories, as well as external candidates chosen on the basis of their prior training and research accomplishments, academic potential, and commitment to research in non-malignant hematology. In addition to rigorous laboratory research training, trainees will participate in a course in conduct of ethical research, departmental career development seminars, grant writing and academic skills training, research conferences, journal clubs, and fellowship program research retreats. Individual Training Plans will be developed for each trainee and progress will be monitored by a multidisciplinary scholarship oversight committees. Trainees will present their work at national meetings and develop applications for career development (K-type) awards. The HTP will take advantage of the extensive research resources of Emory University, including formal course work and degree programs in clinical and translational research available through Emory's CTSA program. Establishment of this program will allow us to train the next generation of academic leaders in pediatric non-malignant hematology.

这项新的T32培训赠款解决了对培训物理科学家和临床的计划的关键需求 小儿非恶性血液学的研究者。血液学研究，尤其是儿科研究 - 阐明了许多遗传，细胞和分子机制，以及疾病过程的基础机制 作为基本细胞功能，例如细胞分化和基因调节。目的地很多 在过去几十年中，血液学的科学和临床进展，资助的研究人员数量 自2002年以来，NIH的血液学相关研究一直在悄悄地下降。血液学培训计划 （HTP）在此T32的支持下，将为博士后医学博士提供严格的基础/翻译研究培训， MD/PhD和PhD研究员，在28位教职员工的心态下支撑了25.7 m的壁外 资金（联邦来源17.3美元）。在埃默里大学（Emory University），在镰状细胞中建立的研究计划 疾病，止血和血栓形成，造血和干细胞生物学，基因治疗和红细胞 生理学和输血医学嵌入了小儿血液学最大的临床计划中 在该国，为儿童的临床和翻译研究提供了巨大的患者量 亚特兰大的医疗保健。与佐治亚理工学院和莫尔豪斯学校的合作伙伴关系 医学扩大了教师的心理库。每个学员将拥有实验室研究导师和临床 培养与儿科血液学相关的基本或翻译研究的同事。高级导师配对 有来自11名年轻教职员工的初级导师将扩大未来导师的供应。 集成到非常成功的小儿血液学/肿瘤学/骨髓移植（BMT）中 Aflac癌症和血液疾病中心的奖学金计划，新的HTP将承认2个研究员 在2年的支持下，培训5-7名MD研究员和3-5位博士学位博士后研究员5年。候选人 将是奖学金培训计划和相关实验室的医学博士，医学博士/博士和博士学位的研究员 以及根据其先前的培训和研究成就选择的外部候选人， 学术潜力和致力于非恶性血液学研究的承诺。除了严格 实验室研究培训，学员将参加一项道德研究的课程，部门 职业发展中心，赠款写作和学术技能培训，研究会议，期刊俱乐部， 和奖学金计划研究务虚会。每个学员将制定个人培训计划， 进度将由多学科奖学金监督委员会监控。学员将展示他们的 在国家职业发展（K-Type）奖项的国家会议和发展应用程序中工作。 HTP将采取 埃默里大学广泛的研究资源的优势，包括正式的课程工作和学位 通过Emory的CTSA计划获得的临床和翻译研究计划。建立这个 计划将使我们能够培训儿科非恶性血液学的下一代学术领导者。