Research Training in Pediatric Non-Malignant Hematology

项目摘要/摘要 在此T32续订申请中，Aflac血液学培训计划(HTP)满足了以下关键需求 在儿科非恶性血液学方面培训内科科学家和临床研究人员的计划。 血液学的研究--特别是儿科学--已经阐明了许多遗传、细胞和分子方面的 疾病过程的潜在机制，以及细胞分化等基本细胞功能 和基因调控。然而，尽管血液学在过去几十年里取得了许多科学和临床进展， 由美国国立卫生研究院资助用于血液学相关研究的研究人员数量继续下降。此HTP提供 对博士后医学博士、医学博士/博士和博士研究生进行严格的基础、翻译研究培训，并在更新中 扩大到包括临床研究培训。在埃默里大学，建立了镰状细胞的研究项目 疾病、止血和血栓形成、造血和干细胞生物学、基因治疗和红细胞生理学 和输血医学被嵌入到全国最大的儿科血液学临床项目中， 为亚特兰大儿童保健中心的临床和转化性研究提供庞大的患者数量。 与佐治亚理工学院的合作扩大了34名教师导师的队伍，其中包括21名 实验室研究人员和13名临床研究人员获得3700万美元的外部资金支持(1440万美元来自 联邦消息来源)。每个实习生将有一名实验室和临床导师，以培养基础、翻译或临床 与儿童血液学相关的研究。从14名年轻人中挑选高级导师和初级导师进行配对 教职员工将扩大未来导师的供应。整合到非常成功的儿科 Aflac癌症与血液血液学/肿瘤学/骨髓移植(BMT)联谊会计划 在精神障碍中心，这个新的HTP在最初的三年半里支持了9名实习生，在更新中将接纳2名 每年支持研究员2年，在5年内培训8-10名医学研究员和2-4名博士后研究员。 应聘者将是Aflac和相关实验室以及外部的医学博士、医学博士和博士研究员 被选中的候选人是因为他们之前的培训，学术潜力，以及对非恶性肿瘤研究的承诺 血液学。除了严格的实验室研究培训外，学员还将参加有关进行 道德研究和提高再现性，部门职业发展研讨会，赠款撰写和 学术技能培训、研究会议、期刊俱乐部和奖学金计划研究务虚会。个体 将为每个受训人员制定培训计划，并通过多学科奖学金监测进展情况 监督委员会。受训者将在当地和全国会议上介绍他们的工作并开发应用程序 职业发展(K型)奖。HTP利用了埃默里大学广泛的研究资源 大学，包括临床和翻译研究方面的正规课程和学位课程 通过埃默里的CTSA计划。该T32的更新将有助于培养下一代学术 儿科非恶性血液学的领军人物。

Project Summary/Abstract In this T32 renewal application, the Aflac Hematology Training Program (HTP) addresses the crucial need for programs to train physician scientists and clinical investigators in pediatric non-malignant hematology. Research in hematology – particularly in pediatrics – has elucidated many of the genetic, cellular and molecular mechanisms underlying disease processes, as well as fundamental cellular functions such as cell differentiation and gene regulation. Yet despite the many scientific and clinical advances in hematology over the past decades, the number of investigators funded by NIH for hematology related research continues to decline. This HTP offers rigorous training in basic, translational research to postdoctoral MD, MD/PhD and PhD fellows, and in renewal is expanded to include clinical research training. At Emory University, established research programs in sickle cell disease, hemostasis and thrombosis, hematopoiesis and stem cell biology, gene therapy, and red cell physiology and transfusion medicine are embedded in the largest clinical program in pediatric hematology in the country, providing huge patient volumes for clinical and translational research within Children’s Healthcare of Atlanta. Partnership with the Georgia Institute of Technology broadens the pool of 34 faculty mentors which includes 21 laboratory researchers and 13 clinical investigators supported by $37.0 M in extramural funding ($14.4 from Federal sources). Each trainee will have a laboratory and clinical Mentor to foster basic, translational, or clinical research relevant to pediatric hematology. Pairing of senior mentors with junior mentors from a pool of 14 young faculty members will expand the supply of future mentors. Integrated into the highly successful Pediatric Hematology/Oncology/Bone Marrow Transplant (BMT) Fellowship Program of the Aflac Cancer and Blood Disorders Center, this new HTP has supported 9 trainees over its first 3 ½ years, and in renewal will admit 2 fellows each year for 2 years of support, training 8-10 MD fellows and 2-4 PhD postdoctoral fellows over 5 years. Candidates will be MD, MD/PhD and PhD fellows within Aflac and associated laboratories, as well as external candidates chosen for their prior training, academic potential, and commitment to research in non-malignant hematology. In addition to rigorous laboratory research training, trainees will participate in courses on conduct of ethical research and enhancing reproducibility, departmental career development seminars, grant writing and academic skills training, research conferences, journal clubs, and fellowship program research retreats. Individual Training Plans will be developed for each trainee and progress will be monitored by multidisciplinary scholarship oversight committees. Trainees will present their work locally and at national meetings and develop applications for career development (K-type) awards. The HTP leverages the extensive research resources of Emory University, including formal course work and degree programs in clinical and translational research available through Emory’s CTSA program. Renewal of this T32 will contribute to training the next generation of academic leaders in pediatric non-malignant hematology.