Role of Articulatory Motor Areas in Central Processing of Speech Sounds in Human Brain

节律性运动区在人脑语音中枢加工中的作用 项目摘要/摘要 这项K23提案的总体目标是为医学博士、博士李莎莎博士提供导师和 职业发展是成为一名独立的、以患者为导向的调查员所必需的，其研究将 促进听觉沟通康复的靶向神经调节疗法的进步。 发音运动皮质在言语感知中的作用仍然是一个备受争议的话题，而 现有的听觉语音处理知识导致缺乏有效的、有针对性的听觉康复 对沟通障碍的干预。尽管听觉过程中皮质运动区的兴奋性 语音处理最近被带到了前台，描绘了语音马达的确切角色 听觉语音处理领域仍然是一个重大挑战。拟议的项目可能有助于建立一个 关节运动系统、其精确的潜在生物标志物和 健康人听觉语音加工的相关行为。我们的具体目标是 以下是：(A)确定运动皮质中语音产生与知觉的表征 功能磁共振成像(FMRI)；(B)确定运动皮质在听觉中的因果作用 使用fMRI引导的导航TMS(NTMS)诱导的暂时性“虚拟病变”模型进行语音处理。 我们的建议将建立在现有的证据基础上，皮质靶向的关节运动区 听觉语音处理，这可能随后转化为听觉方面的进步 沟通康复方法。最终，听觉沟通康复的进展 从这个项目中获得的研究成果对中风和/或肌萎缩侧索硬化症(ALS)大有裨益。 受听觉相关缺陷影响的幸存者。本文件中概述的科学和培训计划 应用程序将以患者为中心的研究体验与卓越的环境中的卓越导师配对 以进一步促进李博士的职业发展。拟议项目的完成将使李博士获得独特的 在听神经科学、高级神经成像和神经调节技术方面的多学科专业知识， 和沟通障碍的专业临床知识，使她能够成功地参加 R01级别。 好了！

Role of Articulatory Motor Areas in Central Processing of Speech Sounds in Human Brain Project Summary/Abstract The overall goal of this K23 proposal is to provide Dr. Shasha Li, MD, PhD, with the mentorship and career development necessary to become an independent, patient-oriented investigator whose research will contribute to advancements in targeted neuromodulation therapy for auditory communication rehabilitation. The role of the articulatory motor cortex in speech perception remains a highly debated subject, and the gap in existing knowledge of auditory speech processing has led to a lack of effective, targeted auditory rehabilitation interventions for communication disorders. Although the excitability of cortical motor regions during auditory speech processing has recently been brought to the foreground, delineating the exact role of speech-motor areas in auditory speech processing remains a major challenge. The proposed project may help establish a direct causal relationship between the articulatory motor system, its precise underlying biomarker, and correlated behaviors of auditory speech processing in healthy human subjects. Our specific aims are the following: (a) To determine representations of speech-sound production vs. perception in motor cortices using functional magnetic resonance imaging (fMRI); (b) To determine the causal role of motor cortex in auditory speech processing using a transient “virtual lesion” model induced by fMRI-guided navigated TMS (nTMS). Our proposal will build upon the existing evidence base for cortical targeting of articulatory motor areas of auditory speech processing, which could subsequently be translated into advancements in auditory communication rehabilitation approaches. Ultimately, advances in auditory communication rehabilitation stemming from this project could significantly benefit stroke and/or amyotrophic lateral sclerosis (ALS) survivors who are affected by auditory-related deficits. The scientific and training plans outlined in this application pair a patient-oriented research experience with superb mentorship in an outstanding environment to further Dr. Li's career development. Completion of the proposed project will result in Dr. Li gaining unique multi-disciplinary expertise in auditory neuroscience, advanced neuroimaging and neuromodulation techniques, and specialized clinical knowledge in communication disorders, allowing her to successfully compete at the R01 level. !