Role of Articulatory Motor Areas in Central Processing of Speech Sounds in Human Brain

发音运动区在人脑语音中央处理中的作用

• 批准号: 10413664
• 负责人: Shasha Li
• 金额: $ 5.4万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10413664
• 关键词: Affect; Amyotrophic Lateral Sclerosis; Area; Auditory; Auditory area; Award; Behavior; Biological Markers; Brain; Clinical; Communication; Communication impairment; Doctor of Philosophy; Environment; Functional Magnetic Resonance Imaging; Human; Intervention; Knowledge; Lesion; Mentored Patient-Oriented Research Career Development Award; Mentorship; Modeling; Motor; Motor Cortex; Neurosciences; Patients; Perception; Production; Quality of life; Rehabilitation therapy; Research; Research Personnel; Role; Speech; Speech Perception; Speech Sound; Stroke; Survivors; System; Techniques; Training; Translating; auditory rehabilitation; career development; evidence base; experience; human subject; image guided; improved; multidisciplinary; neuroimaging; neurological rehabilitation; neuroregulation; noninvasive brain stimulation; patient oriented; patient oriented research; specific biomarkers; speech processing; stem; virtual

Role of Articulatory Motor Areas in Central Processing of Speech Sounds in Human Brain Project Summary/Abstract The supplement to Dr. Shasha Li's existing K23 award, entitled Role of Articulatory Motor Areas in Central Processing of Speech Sounds in Human Brain, which provides Dr. Shasha Li, MD, PhD, with the mentorship and career development necessary to become an independent, patient-oriented investigator whose research will contribute to advancements in targeted neuromodulation therapy for auditory communication rehabilitation. The role of the articulatory motor cortex in speech perception remains a highly debated subject, and the gap in existing knowledge of auditory speech processing has led to a lack of effective, targeted auditory rehabilitation interventions for communication disorders. Although the excitability of cortical motor regions during auditory speech processing has recently been brought to the foreground, delineating the exact role of speech-motor areas in auditory speech processing remains a major challenge. The proposed project may help establish a direct causal relationship between the articulatory motor system, its precise underlying biomarker, and correlated behaviors of auditory speech processing in healthy human subjects. Our specific aims are the following: (a) To determine representations of speech-sound production vs. perception in motor cortices using functional magnetic resonance imaging (fMRI); (b) To determine the causal role of motor cortex in auditory speech processing using a transient “virtual lesion” model induced by fMRI-guided navigated TMS (nTMS). The K23 award will build upon the existing evidence base for cortical targeting of articulatory motor areas of auditory speech processing, which could subsequently be translated into advancements in auditory communication rehabilitation approaches. Ultimately, advances in auditory communication rehabilitation stemming from this project could significantly benefit stroke and/or amyotrophic lateral sclerosis (ALS) survivors who are affected by auditory-related deficits. The scientific and training plans outlined in this award pair a patient-oriented research experience with superb mentorship in an outstanding environment to further Dr. Li's career development. Completion of the proposed project will result in Dr. Li gaining unique multi- disciplinary expertise in auditory neuroscience, advanced neuroimaging and neuromodulation techniques, and specialized clinical knowledge in communication disorders, allowing her to successfully compete at the R01 level. The supplement will greatly facilitate the next critical stage of her career development, and will support her smooth transition to independent research.

发音运动区在人脑语音中枢加工中的作用 项目总结/摘要 李莎莎博士现有的K23奖的补充，题为关节运动区的作用， 人脑中语音的中央处理，为李莎莎博士提供了 成为一名独立的、以患者为导向的研究者所必需的指导和职业发展， 研究将有助于听觉交流的靶向神经调节治疗的进展 康复活动.发音运动皮层在言语感知中的作用仍然是一个备受争议的话题， 而现有听觉语音处理知识的差距导致缺乏有效的、有针对性的 沟通障碍的听觉康复干预。虽然皮层运动神经元的兴奋性 听觉语音处理过程中的区域最近被带到了前台，描绘了准确的 言语运动区在听觉言语处理中的作用仍然是一个主要的挑战。拟建项目 可能有助于建立发音运动系统之间的直接因果关系，其精确的基础， 生物标志物和健康人类受试者的听觉语音处理的相关行为。我们的具体 目的如下：（a）确定运动中言语声音产生与感知的表征 （B）确定运动皮层的因果作用 在听觉语音处理中，使用由fMRI引导的导航TMS诱导的瞬时“虚拟损伤”模型， （nTMS）。K23奖将建立在现有的证据基础上，用于关节运动的皮质靶向 听觉语言处理领域，随后可以转化为听觉语言处理领域的进步。 通信恢复方法。最终，听觉交流康复的进展 该项目产生的结果可能会显著有益于中风和/或肌萎缩性侧索硬化症（ALS） 幸存者谁是受影响的相关缺陷。该奖项中概述的科学和培训计划 在一个出色的环境中，将以患者为导向的研究经验与一流的指导相结合， 博士李的职业发展。完成拟议的项目将导致李博士获得独特的多- 在听觉神经科学，先进的神经成像和神经调节技术的学科专业知识， 沟通障碍方面的专业临床知识，使她能够成功地参加R 01比赛 水平该补充将大大有助于她职业发展的下一个关键阶段，并将支持 她顺利过渡到独立研究。