Role of Articulatory Motor Areas in Central Processing of Speech Sounds in Human Brain

节律性运动区在人脑语音中枢加工中的作用 项目摘要/摘要 李莎莎博士现有的K23奖的补充，题为节律性运动区在 人类大脑中语音的中央处理，这为医学博士李莎莎博士提供了 成为一名独立的、以病人为导向的调查员所必需的导师和职业发展 研究将有助于促进听觉沟通的靶向神经调节疗法的进步 康复。发音运动皮质在言语感知中的作用仍然是一个高度争论的话题， 现有的听觉语音处理知识的空白导致了缺乏有效的、有针对性的 沟通障碍的听觉康复干预。尽管皮质运动的兴奋性 听觉语音处理过程中的区域最近被带到了前台，描绘了准确的 语音运动区在听觉语音处理中的作用仍然是一个重大挑战。拟议中的项目 可能有助于建立关节运动系统之间的直接因果关系，其确切的基础 健康受试者听觉语音处理的生物标志物及相关行为。我们的特定 目标如下：(A)确定言语-声音产生与运动知觉的表征 使用功能磁共振成像(FMRI)；(B)确定运动皮质的因果作用 在听觉语音处理中使用fMRI导航式TMS诱导的暂时性“虚拟病变”模型 (NTMS)。K23奖将建立在关节运动皮质靶向的现有证据基础上 听觉语音处理的领域，这可能随后转化为听觉方面的进步 沟通康复方法。最终，听觉沟通康复的进展 从这个项目中获得的研究成果对中风和/或肌萎缩侧索硬化症(ALS)大有裨益。 受听觉相关缺陷影响的幸存者。该奖项中概述的科学和培训计划 将以患者为中心的研究经验与卓越环境中的卓越导师相结合，以进一步 李博士的职业发展。拟议项目的完成将使李博士获得独特的多项 在听神经科学、高级神经成像和神经调节技术方面的学科专业知识，以及 沟通障碍方面的专业临床知识，使她能够成功参加R01比赛 水平。该副刊将极大地促进她职业发展的下一个关键阶段，并将支持 她顺利过渡到独立研究。

Role of Articulatory Motor Areas in Central Processing of Speech Sounds in Human Brain Project Summary/Abstract The supplement to Dr. Shasha Li's existing K23 award, entitled Role of Articulatory Motor Areas in Central Processing of Speech Sounds in Human Brain, which provides Dr. Shasha Li, MD, PhD, with the mentorship and career development necessary to become an independent, patient-oriented investigator whose research will contribute to advancements in targeted neuromodulation therapy for auditory communication rehabilitation. The role of the articulatory motor cortex in speech perception remains a highly debated subject, and the gap in existing knowledge of auditory speech processing has led to a lack of effective, targeted auditory rehabilitation interventions for communication disorders. Although the excitability of cortical motor regions during auditory speech processing has recently been brought to the foreground, delineating the exact role of speech-motor areas in auditory speech processing remains a major challenge. The proposed project may help establish a direct causal relationship between the articulatory motor system, its precise underlying biomarker, and correlated behaviors of auditory speech processing in healthy human subjects. Our specific aims are the following: (a) To determine representations of speech-sound production vs. perception in motor cortices using functional magnetic resonance imaging (fMRI); (b) To determine the causal role of motor cortex in auditory speech processing using a transient “virtual lesion” model induced by fMRI-guided navigated TMS (nTMS). The K23 award will build upon the existing evidence base for cortical targeting of articulatory motor areas of auditory speech processing, which could subsequently be translated into advancements in auditory communication rehabilitation approaches. Ultimately, advances in auditory communication rehabilitation stemming from this project could significantly benefit stroke and/or amyotrophic lateral sclerosis (ALS) survivors who are affected by auditory-related deficits. The scientific and training plans outlined in this award pair a patient-oriented research experience with superb mentorship in an outstanding environment to further Dr. Li's career development. Completion of the proposed project will result in Dr. Li gaining unique multi- disciplinary expertise in auditory neuroscience, advanced neuroimaging and neuromodulation techniques, and specialized clinical knowledge in communication disorders, allowing her to successfully compete at the R01 level. The supplement will greatly facilitate the next critical stage of her career development, and will support her smooth transition to independent research.