Role of Articulatory Motor Areas in Central Processing of Speech Sounds in Human Brain

发音运动区在人脑语音中央处理中的作用

• 批准号: 9804820
• 负责人: Shasha Li
• 金额: $ 19.85万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9804820
• 关键词: Adult; Affect; Amyotrophic Lateral Sclerosis; Anterior; Area; Auditory; Auditory Perception; Auditory area; Behavior; Biological Markers; Brain; Clinical; Communication; Communication impairment; Data; Decision Making; Development; Discrimination; Doctor of Philosophy; Effectiveness; Environment; Foundations; Functional Magnetic Resonance Imaging; Gestures; Goals; Hand; Human; Individual; Individual Differences; Intervention; Knowledge; Left; Lesion; Mentored Patient-Oriented Research Career Development Award; Mentorship; Methods; Mission; Modeling; Motor; Motor Cortex; Motor Evoked Potentials; National Institute on Deafness and Other Communication Disorders; Neurorehabilitation; Neurosciences; Patients; Perception; Performance; Population; Prefrontal Cortex; Process; Production; Quality of life; Recovery; Rehabilitation therapy; Research; Research Personnel; Role; Signal Detection Analysis; Signal Transduction; Speech; Speech Perception; Speech Sound; Stroke; Structure; Survivors; System; Techniques; Testing; Training; Transcranial magnetic stimulation; Translating; auditory rehabilitation; base; behavior measurement; career development; delta opioid receptor; electric field; evidence base; experience; frontal lobe; human subject; image guided; improved; knowledge of results; multidisciplinary; neuroimaging; neuroregulation; novel; patient oriented; patient oriented research; response; specific biomarkers; speech processing; stem; theories; virtual; vocalization

Role of Articulatory Motor Areas in Central Processing of Speech Sounds in Human Brain Project Summary/Abstract The overall goal of this K23 proposal is to provide Dr. Shasha Li, MD, PhD, with the mentorship and career development necessary to become an independent, patient-oriented investigator whose research will contribute to advancements in targeted neuromodulation therapy for auditory communication rehabilitation. The role of the articulatory motor cortex in speech perception remains a highly debated subject, and the gap in existing knowledge of auditory speech processing has led to a lack of effective, targeted auditory rehabilitation interventions for communication disorders. Although the excitability of cortical motor regions during auditory speech processing has recently been brought to the foreground, delineating the exact role of speech-motor areas in auditory speech processing remains a major challenge. The proposed project may help establish a direct causal relationship between the articulatory motor system, its precise underlying biomarker, and correlated behaviors of auditory speech processing in healthy human subjects. Our specific aims are the following: (a) To determine representations of speech-sound production vs. perception in motor cortices using functional magnetic resonance imaging (fMRI); (b) To determine the causal role of motor cortex in auditory speech processing using a transient “virtual lesion” model induced by fMRI-guided navigated TMS (nTMS). Our proposal will build upon the existing evidence base for cortical targeting of articulatory motor areas of auditory speech processing, which could subsequently be translated into advancements in auditory communication rehabilitation approaches. Ultimately, advances in auditory communication rehabilitation stemming from this project could significantly benefit stroke and/or amyotrophic lateral sclerosis (ALS) survivors who are affected by auditory-related deficits. The scientific and training plans outlined in this application pair a patient-oriented research experience with superb mentorship in an outstanding environment to further Dr. Li's career development. Completion of the proposed project will result in Dr. Li gaining unique multi-disciplinary expertise in auditory neuroscience, advanced neuroimaging and neuromodulation techniques, and specialized clinical knowledge in communication disorders, allowing her to successfully compete at the R01 level. !

发音运动区在人脑语音中枢加工中的作用 项目总结/摘要 本K23提案的总体目标是为李莎莎博士（MD，PhD）提供指导， 职业发展成为一个独立的，以病人为导向的研究者，其研究将 有助于听觉沟通康复的靶向神经调节治疗的进步。 发音运动皮层在言语感知中的作用仍然是一个备受争议的话题， 现有的听觉言语处理知识导致缺乏有效的、有针对性的听觉康复 沟通障碍的干预措施。虽然在听觉过程中皮质运动区的兴奋性 语言处理最近被提到了前台，描绘了语言运动的确切作用 听觉语音处理的区域仍然是一个主要的挑战。拟议的项目可能有助于建立一个 发音运动系统、其精确的基础生物标志物和 相关行为的听觉语音处理在健康的人类受试者。我们的具体目标是 （a）确定运动皮层中语音产生与感知的表征， 功能性磁共振成像（fMRI）;（B）确定运动皮层在听觉系统中的因果作用。 使用由fMRI引导的导航TMS（nTMS）诱导的瞬时“虚拟病变”模型的语音处理。 我们的建议将建立在现有的证据基础上，皮质靶向的发音运动区， 听觉语音处理，随后可以转化为听觉的进步， 通信恢复方法。最终，听觉交流康复的进展 该项目产生的结果可能会显著有益于中风和/或肌萎缩性侧索硬化症（ALS） 幸存者谁是受影响的相关缺陷。本报告中概述的科学和培训计划 应用配对以病人为导向的研究经验与一流的导师在一个优秀的环境 李博士的职业发展完成拟议的项目将导致李博士获得独特的 听觉神经科学、先进神经成像和神经调节技术方面的多学科专业知识， 以及沟通障碍方面的专业临床知识，使她能够成功地参加 R 01级。 !