课题基金 / 基金详情

Full-scale biophysical modeling of hippocampal networks during spatial navigation and memory replay

Full-scale biophysical modeling of hippocampal networks during spatial navigation and memory replay
空间导航和记忆回放过程中海马网络的全面生物物理建模
批准号:
10202755
负责人:
IVAN SOLTESZ
金额:
$42.24万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
已结题
起止时间:
2017-09-25 至 2023-06-30

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中文摘要
翻译
在我们对海马体记忆回放机制的调查中,我们将
英文摘要
Throughout our investigation of the mechanisms underlying hippocampal memory replay, we will employ a strategy of continuous interaction between experimental and modeling approaches. First, we consider conceptual models, and formulate hypotheses relevant to the initiation, generation and termination of SPW-Rs. Then, as we gather critical new experimental data to test those hypotheses in Projects 1-4, we will use that data to constrain full-scale biophysically-detailed computational models of hippocampal networks, integrating a newly developed model of CA3 with existing models of dentate gyrus (DG) and CA1. These models will then be used to predict the complex responses of the network to simulated perturbations, help interpret experimental outcomes, inform hypotheses about underlying principles, and suggest new experiments to test those hypotheses. In addition to an improved conceptual understanding of memory replay, our final product will include full-scale network models of the hippocampus with unprecedented functionality, fully open-sourced and freely available to the broader neuroscience community. !
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会议论文
2019 Inhibition in the CNS Gordon Research Conference and Gordon Research Seminar
  • 批准号:
    9750981
  • 项目类别:
  • 资助金额:
    $2.0万
  • 财政年份:
    2019
  • 负责人:
    IVAN SOLTESZ
  • 依托单位:
Data Science Resource Core
  • 批准号:
    10202750
  • 项目类别:
  • 资助金额:
    $27.37万
  • 财政年份:
    2017
  • 负责人:
    IVAN SOLTESZ
  • 依托单位:
Towards automated phenotyping in epilepsy
  • 批准号:
    9369284
  • 项目类别:
  • 资助金额:
    $19.75万
  • 财政年份:
    2017
  • 负责人:
    IVAN SOLTESZ
  • 依托单位:
Administrative Core
  • 批准号:
    10202749
  • 项目类别:
  • 资助金额:
    $25.35万
  • 财政年份:
    2017
  • 负责人:
    IVAN SOLTESZ
  • 依托单位:
国内基金
海外基金
Behavioral Insights on Cooperation in Social Dilemmas
  • 批准号:
    --
  • 项目类别:
    外国优秀青年学者研究基金项目
  • 资助金额:
    --
  • 批准年份:
    2024
  • 负责人:
    LIEN,Jaimie Wei-Hung
  • 依托单位: