Full-scale biophysical modeling of hippocampal networks during spatial navigation and memory replay
Full-scale biophysical modeling of hippocampal networks during spatial navigation and memory replay
批准号:
10202755
负责人:
IVAN SOLTESZ
金额:
$42.24万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
已结题
起止时间:
2017-09-25 至 2023-06-30
关键词:
Amygdaloid structureBehavioralBiophysicsCellsCodeCommunitiesCompanionsComplexComputer ModelsDataElementsExhibitsExperimental ModelsGenerationsGoalsHippocampus (Brain)InterneuronsInvestigationKnowledgeLocationMediatingMemoryModelingNeuronsNeurosciencesOutcomeOutputPatternPhysiologicalPopulationPrefrontal CortexPropertyRecurrenceSeriesSignal TransductionSynapsesTestingWorkbiophysical modelcell typedentate gyrusexperimental studyimprovedlarge scale simulationnetwork modelsneuronal circuitryopen sourceresponsesegregationsimulationspatial memoryway finding
中文摘要
在我们对海马记忆重放机制的研究中,我们将
采用实验和建模方法之间持续互动的策略。第一、
我们考虑概念模型,并制定相关的启动,生成和
SPW-Rs的终止。然后,当我们收集关键的新实验数据来测试这些假设时,
项目1-4,我们将使用这些数据来约束全尺寸生物制药学详细的计算模型
海马网络,整合新开发的CA 3模型与现有的齿状回模型,
海马回(DG)和CA 1.然后,这些模型将用于预测网络的复杂响应
模拟扰动,帮助解释实验结果,告知有关潜在的假设
原则,并提出新的实验来测试这些假设。除了改进的
我们的最终产品将包括完整的网络模型,
海马具有前所未有的功能,完全开源,免费提供给
更广泛的神经科学社区。
!
英文摘要
Throughout our investigation of the mechanisms underlying hippocampal memory replay, we will
employ a strategy of continuous interaction between experimental and modeling approaches. First,
we consider conceptual models, and formulate hypotheses relevant to the initiation, generation and
termination of SPW-Rs. Then, as we gather critical new experimental data to test those hypotheses in
Projects 1-4, we will use that data to constrain full-scale biophysically-detailed computational models
of hippocampal networks, integrating a newly developed model of CA3 with existing models of dentate
gyrus (DG) and CA1. These models will then be used to predict the complex responses of the network
to simulated perturbations, help interpret experimental outcomes, inform hypotheses about underlying
principles, and suggest new experiments to test those hypotheses. In addition to an improved
conceptual understanding of memory replay, our final product will include full-scale network models of
the hippocampus with unprecedented functionality, fully open-sourced and freely available to the
broader neuroscience community.
!
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
2019 Inhibition in the CNS Gordon Research Conference and Gordon Research Seminar
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批准号:9750981
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项目类别:
-
资助金额:$2.0万
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财政年份:2019
-
负责人:IVAN SOLTESZ
-
依托单位:
Data Science Resource Core
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批准号:10202750
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项目类别:
-
资助金额:$27.37万
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财政年份:2017
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负责人:IVAN SOLTESZ
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依托单位:
Towards automated phenotyping in epilepsy
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批准号:9369284
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项目类别:
-
资助金额:$19.75万
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财政年份:2017
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负责人:IVAN SOLTESZ
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依托单位:
Administrative Core
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批准号:10202749
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项目类别:
-
资助金额:$25.35万
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财政年份:2017
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负责人:IVAN SOLTESZ
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依托单位:
Cannabinoid control of epilepsy
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批准号:10115138
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项目类别:
-
资助金额:$35.08万
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财政年份:2017
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负责人:IVAN SOLTESZ
-
依托单位:
Cannabinoid control of epilepsy
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批准号:9899338
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项目类别:
-
资助金额:$35.04万
-
财政年份:2017
-
负责人:IVAN SOLTESZ
-
依托单位:
Optogenetic hub cell control for no seizures, no side-effects temporal lobe epilepsy
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批准号:9165938
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项目类别:
-
资助金额:$0.49万
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财政年份:2015
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负责人:IVAN SOLTESZ
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依托单位:
Towards a Complete Description of the Circuitry Underlying Memory replay.
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批准号:8935978
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项目类别:
-
资助金额:$70.7万
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财政年份:2014
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负责人:IVAN SOLTESZ
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依托单位:
Towards a Complete Description of the Circuitry Underlying Memory replay.
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批准号:9265151
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项目类别:
-
资助金额:$12.35万
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财政年份:2014
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负责人:IVAN SOLTESZ
-
依托单位:
Towards a Complete Description of the Circuitry Underlying Memory replay.
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批准号:9150321
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项目类别:
-
资助金额:$64.8万
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财政年份:2014
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负责人:IVAN SOLTESZ
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依托单位:
GABAergic regulation of entorhino-hippocampal excitability in epilepsy.
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批准号:8110718
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项目类别:
-
资助金额:$32.85万
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财政年份:2011
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负责人:IVAN SOLTESZ
-
依托单位:
Optogenetic hub cell control for no seizures, no side-effects in temporal lobe ep
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批准号:8233421
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项目类别:
-
资助金额:$29.79万
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财政年份:2011
-
负责人:IVAN SOLTESZ
-
依托单位:
GABAergic regulation of entorhino-hippocampal excitability in epilepsy.
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批准号:8787804
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项目类别:
-
资助金额:$19.52万
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财政年份:2011
-
负责人:IVAN SOLTESZ
-
依托单位:
GABAergic regulation of entorhino-hippocampal excitability in epilepsy.
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批准号:8217083
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项目类别:
-
资助金额:$32.76万
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财政年份:2011
-
负责人:IVAN SOLTESZ
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依托单位:
GABAergic regulation of entorhino-hippocampal excitability in epilepsy.
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批准号:8402403
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项目类别:
-
资助金额:$31.52万
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财政年份:2011
-
负责人:IVAN SOLTESZ
-
依托单位:
Optogenetic hub cell control for no seizures, no side-effects in temporal lobe ep
-
批准号:8624720
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项目类别:
-
资助金额:$28.77万
-
财政年份:2011
-
负责人:IVAN SOLTESZ
-
依托单位:
Optogenetic hub cell control for no seizures, no side-effects in temporal lobe ep
-
批准号:8129962
-
项目类别:
-
资助金额:$29.89万
-
财政年份:2011
-
负责人:IVAN SOLTESZ
-
依托单位:
Optogenetic hub cell control for no seizures, no side-effects in temporal lobe ep
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批准号:8420458
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项目类别:
-
资助金额:$28.64万
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财政年份:2011
-
负责人:IVAN SOLTESZ
-
依托单位:
GABAergic regulation of entorhino-hippocampal excitability in epilepsy.
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批准号:8598945
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项目类别:
-
资助金额:$32.22万
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财政年份:2011
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负责人:IVAN SOLTESZ
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依托单位:
Limbic Excitability after Febrile Seizures
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批准号:6470162
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项目类别:
-
资助金额:$28.58万
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财政年份:1999
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负责人:IVAN SOLTESZ
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依托单位:
国内基金
海外基金
Behavioral Insights on Cooperation in Social Dilemmas
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批准号:--
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项目类别:外国优秀青年学者研究基金项目
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资助金额:--
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批准年份:2024
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负责人:LIEN,Jaimie Wei-Hung
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依托单位: