Multi-scale spatial heterogeneity enhances particle clearance in airway ciliary arrays.
Multi-scale spatial heterogeneity enhances particle clearance in airway ciliary arrays.
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DOI：
10.1038/s41567-020-0923-8
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发表时间：
2020-09
期刊：
影响因子：
19.6
通讯作者：
中科院分区：
文献类型：
--
作者：
粘液清除是呼吸系统抵御病毒、细菌和环境侵害的主要防御措施。这种跨越整个气道的运输是由数千个多纤毛细胞的综合活动产生的，每个细胞都包含数百个纤毛，这些细胞必须共同协调它们的空间排列、排列和运动。流体输送的机制已在单个纤毛、集体移动的异时波以及更普遍的活性物质的流体动力学水平上进行了广泛的研究。然而，局部纤毛结构和它们产生的流动拓扑之间的联系在很大程度上仍未被探索。在这里，我们对小鼠气道进行了从亚细胞（nm）到器官尺度（mm）的成像，定量表征了其纤毛排列和产生的流量。我们在局部测量纤毛组织和流动结构的异质性，但跨气管的流体输送是连贯的。为了检验这一结果，开发了一个流体动力学模型，用于系统地探索不同的组织结构。令人惊讶的是，我们发现紊乱会增强颗粒清除，无论它是源于多纤毛细胞排列的波动、异质性还是纤毛错位。这类似于“随机共振”的元素，从某种意义上说，噪声可以改善系统的功能。总而言之，我们的结果揭示了活性地毯的微观结构如何决定其涌现的动态。此外，这项工作还直接适用于人类呼吸道疾病，这是全球第三大死亡原因。
Mucus clearance constitutes the primary defence of the respiratory system against viruses, bacteria and environmental insults. This transport across the entire airway emerges from the integrated activity of thousands of multiciliated cells, each containing hundreds of cilia, which together must coordinate their spatial arrangement, alignment and motility. The mechanisms of fluid transport have been studied extensively at the level of an individual cilium, collectively moving metachronal waves, and more generally the hydrodynamics of active matter. However, the connection between local cilia architecture and the topology of the flows they generate remains largely unexplored. Here, we image the mouse airway from the sub-cellular (nm) to the organ scales (mm), characterising quantitatively its ciliary arrangement and the generated flows. Locally we measure heterogeneity in both cilia organisation and flow structure, but across the trachea fluid transport is coherent. To examine this result, a hydrodynamic model was developed for a systematic exploration of different tissue architectures. Surprisingly, we find that disorder enhances particle clearance, whether it originates from fluctuations, heterogeneity in multiciliated cell arrangement or ciliary misalignment. This resembles elements of ‘stochastic resonance’, in the sense that noise can improve the function of the system. Taken together, our results shed light on how the microstructure of an active carpet determines its emergent dynamics. Furthermore, this work is also directly applicable to human airway pathologies, which are the third leading cause of deaths worldwide.
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影响因子：
3.7
作者：
Ding, Yang;Nawroth, Janna C.;Kanso, Eva
通讯作者：
Kanso, Eva
DOI：
10.1056/nejmra0910061
发表时间：
2010-12-02
期刊：
The New England journal of medicine
影响因子：
--
作者：
Fahy JV;Dickey BF
通讯作者：
Dickey BF
带有自由血管化肌筋膜皮瓣的气管重建：在人类临床应用的猪模型中进行临床前研究。
影响因子：
4.6
作者：
Kim WS;Chang JW;Jang WS;Seo YJ;Kang ML;Sung HJ;Kim DH;Kim JM;Park JH;Ban MJ;Na G;Shin SH;Byeon HK;Koh YW;Kim SH;Baik HK;Choi EC
通讯作者：
Choi EC
影响因子：
56.9
作者：
Faubel, Regina;Westendorf, Christian;Eichele, Gregor
通讯作者：
Eichele, Gregor
影响因子：
3.4
作者：
Feriani, Luigi;Juenet, Maya;Cicuta, Pietro
通讯作者：
Cicuta, Pietro