Functional relations between alcohol use and mental/physical health in the wake of the COVID-19 pandemic

COVID-19 大流行后饮酒与心理/身体健康之间的功能关系

• 批准号: 10203554
• 负责人: Christina M Sheerin
• 金额: $ 5.54万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10203554
• 关键词: Acute; Address; Affect; Alcohol Phenotype; Alcohol abuse; Alcohol consumption; Alcohol or Other Drugs use; Alcohols; Behavioral; COVID-19; COVID-19 pandemic; Consumption; Cross-Sectional Studies; Data; Data Collection; Data Sources; Development; Disease; Distress; Ecological momentary assessment; Exposure to; Future; Goals; Grant; Health; Hour; Immune system; Individual; Infection; K-Series Research Career Programs; Knowledge; Lead; Literature; Measures; Medical; Mental Health; Mentors; Mentorship; Methodology; Methods; Modeling; National Institute on Alcohol Abuse and Alcoholism; Nature; Outcome; Parents; Participant; Pathway interactions; Patient Self-Report; Phenotype; Population; Populations at Risk; Positioning Attribute; Post-Traumatic Stress Disorders; Predisposition; Prevention; Process; Protocols documentation; Psyche structure; Public Health; Recurrence; Registries; Reporting; Research; Research Priority; Risk; Risk Behaviors; Risk Factors; Series; Severities; Severity of illness; Social Distance; Stress; Surveys; Symptoms; Testing; Time; Training; Trauma; Veterans; Work; alcohol misuse; alcohol related problem; alcohol use disorder; binge drinking; career development; cohort; combat; comorbidity; coronavirus disease; drinking; experience; fighting; follow-up; high risk; immune health; infection risk; longitudinal dataset; multidisciplinary; pandemic disease; physical conditioning; prospective; recruit; research and development; response; skills; social; stem; stressor; transmission process; traumatic event; traumatic stress; treatment trial

Project Summary Beyond the impact of infection itself, the COVID-19 pandemic has resulted in far-reaching effects on behavioral, social, psychiatric, and substance use outcomes. Early data has documented increases in alcohol use in the wake of the pandemic, consistent with prior evidence of increased alcohol consumption during times of stress and following traumatic events. Immediate and downstream implications of increased alcohol use, and development of alcohol use disorder (AUD), on public health include the interplay between alcohol use and psychiatric distress (i.e., posttraumatic stress disorder; PTSD), potential for problematic alcohol use to increase behavioral risk for infection/transmission of COVID-19, and the possibility that weakened immune systems and health conditions associated with AUD may impact disease severity in those who develop COVID-19. The overarching goals of this K01 Supplement are twofold. First, this supplement aims to extend the PI's training to incorporate health impacts of AUD and how it relates to COVID-19 risk and severity, along with analytic training in longitudinal modeling and methodological training in an intensive time-series data collection method to try and develop a mechanistic understanding of the functional relations between alcohol use, PTSD, risky behaviors, and health outcomes. Second, two new research aims associated with these training aims were added which seek to address gaps in the current stress and alcohol use literature by leveraging an existing, longitudinal dataset, with prospective (i.e., pre-pandemic) data. The two new research aims are to 1) assess the immediate, and trajectory of, COVID-19 impacts on alcohol phenotypes (e.g., consumption, binge drinking, problems) in comparison to pre-pandemic data and 2) in the context of COVID-19 as an ongoing stressor, collect repeated, time-series data to examine the temporal relations between alcohol phenotypes, PTSD, and COVID-specific risky behaviors (e.g., lack of social distancing). To achieve these training and research aims, an additional mentor with expertise in both the health impact of AUD and COVID-19 treatment trials has been added to the multidisciplinary mentorship team. Further, the PI's primary K01 mentor has specific expertise in the implementation of COVID-19 surveys on substance and mental health outcomes and experience with time-series data collection in traumatic stress populations. The proposed research represents an important contribution towards advancing our understanding of the complicated interrelationship between AUD, PTSD, and risky behaviors in the context of the COVID-19 pandemic to determine not only who is at risk, but when risk behaviors occur. This information will be important for attempts to plan for a public health response during and after the pandemic. Under the umbrella of a career development award, this pilot data will inform future large-scale studies and R-level grants aimed at identification and prevention of COVID-19-related impact, further positioning the PI to continue this line of work by adapting ongoing training to be responsive to medical pandemics and decrease the burden of alcohol-related problems, consistent with NIAAA research priority.

项目摘要 除了感染本身的影响外，COVID-19大流行对 行为、社会、精神和物质使用结果。早期的数据显示， 在大流行之后使用，与之前的证据一致，即在大流行期间饮酒量增加， 压力和创伤事件的影响酒精使用增加的直接和下游影响，以及 酒精使用障碍（AUD）的发展，对公共卫生的影响包括酒精使用和 精神痛苦（即，创伤后应激障碍（PTSD），酗酒问题的可能性增加， 感染/传播COVID-19的行为风险，以及削弱免疫系统和 与AUD相关的健康状况可能会影响COVID-19患者的疾病严重程度。的 本K 01补充的总体目标是双重的。首先，这一补充旨在扩大PI的培训， 结合澳元的健康影响及其与COVID-19风险和严重程度的关系，沿着分析培训 在纵向建模和密集的时间序列数据收集方法的方法培训，尝试和 发展对酒精使用、创伤后应激障碍、危险行为之间的功能关系的机械理解， 和健康结果。其次，增加了与这些培训目标相关的两个新的研究目标， 寻求解决目前的压力和酒精使用文献的差距，利用现有的，纵向 数据集，具有前瞻性（即，大流行前）的数据。两个新的研究目标是1）评估即时， 和轨迹，COVID-19对酒精表型的影响（例如，消费，酗酒，问题）， 与大流行前的数据进行比较，以及2）在COVID-19作为持续压力源的背景下，重复收集， 时间序列数据，以检查酒精表型，PTSD和COVID特异性 危险行为（例如，缺乏社会距离）。为了实现这些培训和研究目标， 在AUD和COVID-19治疗试验的健康影响方面具有专业知识的专家已被添加到 多学科指导团队。此外，PI的主要K 01导师在以下方面具有特定的专业知识： 实施COVID-19物质和精神健康结果调查以及时间序列经验 在创伤应激人群中收集数据。拟议的研究代表了一个重要的贡献 这有助于我们进一步理解AUD，PTSD和风险之间复杂的相互关系。 在COVID-19大流行背景下的行为，不仅要确定谁面临风险，还要确定何时出现风险行为 发生.这一信息对于在危机期间和之后试图规划公共卫生应对措施将是重要的。 流行病在职业发展奖的保护伞下，这些试点数据将为未来的大规模研究提供信息 和R级赠款，旨在识别和预防COVID-19相关影响，进一步定位PI 通过调整正在进行的培训，以应对医学流行病，并减少 酒精相关问题的负担，符合NIAAA的研究重点。