终末期肾病的 HDL 功能和死亡率-猫眼课题宝

终末期肾病的 HDL 功能和死亡率

批准号：

10205993

负责人：

Hamid Moradi

金额：

$0.0万

依托单位：

VETERANS HEALTH ADMINISTRATION

依托单位国家：

美国

项目类别：

财政年份：

2015

资助国家：

美国

项目状态：

已结题

起止时间：

2015-01-01 至 2022-12-31

来源：

https://reporter.nih.gov/project-details/10205993

关键词：

Acids Age Anti-Inflammatory Agents Antioxidants Apolipoprotein A-I Area Atherosclerosis Award California Cardiovascular Diseases Cardiovascular system Caring Cell Culture Techniques Ceramides Cessation of life Chronic Kidney Failure Clinical Clinical Data Clinical Research Coronary Arteriosclerosis Data Collection Deficiency Diseases Diabetes Mellitus Dialysis patients Dialysis procedure Disease susceptibility End stage renal failure Endocannabinoids Environment Ethnic Origin Evaluation Fatty Acids Foundations Functional disorder Future Gender General Population Goals Healthcare Systems Hemodialysis High Density Lipoprotein Cholesterol High Density Lipoproteins High Prevalence Hypertension In Vitro Inflammation Investigation K-Series Research Career Programs Knowledge Laboratories Legal patent Lipids Low Density Lipoprotein oxidation Maintenance Malignant Neoplasms Measurement Measures Mediator of activation protein Mentors Mentorship Metabolism Modeling National Institute of Diabetes and Digestive and Kidney Diseases Outcome Oxidative Stress Pathway interactions Patients Pharmacology Pharmacology Study Phenotype Play Population Prevalence Prevention Production Property Prospective cohort Public Health Race Research Personnel Resources Role Sampling Serum Signal Pathway Techniques Therapeutic Time Training Training Programs Translational Research United States Veterans adjudication amidase atherogenesis base cardiovascular disorder risk cardiovascular risk factor career cohort design epidemiology study experience experimental study high risk improved inhibitor/antagonist innovation military veteran mortality mortality risk multidisciplinary new therapeutic target novel patient population prognostic prospective public health relevance reverse cholesterol transport targeted treatment tool

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DESCRIPTION (provided by applicant): Approximately 9% of the United States population have chronic kidney disease, although, this prevalence is even higher in Veterans given the high prevalence of diabetes and hypertension (underlying causes of CKD) in this patient population. Out of this staggering number, approximately 450,000 patients have end stage renal disease (ESRD) requiring maintenance dialysis. The number of patients with ESRD is expected to increase to 700,000 by 2020. Five year survival for patients on dialysis is about 35%, a rate worse than many cancers. Half of these deaths are attributed to cardiovascular disease (CVD). Therefore, investigations aimed at discovering novel pathways/molecules that can identify patients at high risk for CVD are of vital importance. Furthermore, these pathways can be explored to identify potential targets for therapy. Given the critical role HDL plays in prevention and reversal of CVD, studies aimed at evaluating and improving HDL function in ESRD patients are of considerable clinical and therapeutic value.

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