Mouse Phenome Database: NIA Interventions Testing Program Data Coordinating Center

项目摘要/摘要 NIA干预测试计划(ITP)是一项调查干预措施的多机构研究 有可能延长小鼠的寿命，延缓疾病或功能障碍。干预措施在以下位置并行测试 三个站点(杰克逊实验室、密歇根大学和德克萨斯大学)使用相同的 标准化协议。此类治疗包括药品、营养食品、食品、膳食补充剂、 植物提取物、激素、多肽、氨基酸、螯合剂、氧化还原试剂和其他化合物或混合物 化合物。我们建议推进小鼠表现组数据库(MPD)，以应对新出现的 老龄化研究社区，特别是ITP，成为一个数据协调中心(DCC)，负责 ITP数据，通过公共数据库提供，并提供使用户能够可视化的工具， 分析并下载这些研究的主要数据和摘要数据。我们的目标是提供一个 数据、文档和协议的中央存储库，为ITP提供了一个独特而重要的场所 调查人员需要公开他们的数据；不断改进和开发工具和功能，以最大限度地 定位、呈现和分析这些数据集；并维护、增强和推广此资源以进一步 实现量化、标准化和预测性的表型研究，进而促进新的科学进步 在老龄化领域。在过去的五年中，我们设计了一个可供公众访问的网站和数据 ITP的存储库。我们还整理和发布了许多ITP研究的数据。ITP计划 未来五年包括更多的寿命试验，对发现的延长寿命的药物进行详细分析，以及 关于健康结果的数据持续增长。为了帮助支持这些目标，我们的具体目标是：1)完善 并维护当前的MPD-ITP网站，2)使用经过严格管理的ITP数据填充MPD，3)开发和 扩展MPD工具套件以支持ITP数据的灵活分析和可视化，以及4)开发和 维护可公开访问的ITP生物检疫数据库，供外部调查人员进行 以合作的方式进行自己的学习。ITP发展协调中心的拟议工作完成后，将产生 强大的公平合规系统(可查找、可访问、可互操作和可重复使用)，可供公众访问和 ITP数据分析。这将有助于最大化这些数据的价值，并提供可追溯性和 ITP检测结果的扩展和翻译所需的重复性。

PROJECT SUMMARY/ABSTRACT The NIA Interventions Testing Program (ITP) is a multi-institutional study investigating interventions with the potential to extend lifespan and delay disease or dysfunction in mice. Interventions are tested in parallel at three sites (The Jackson Laboratory, University of Michigan, and University of Texas) using identical standardized protocols. Such treatments include pharmaceuticals, nutraceuticals, foods, dietary supplements, plant extracts, hormones, peptides, amino acids, chelators, redox agents, and other compounds or mixtures of compounds. We propose to advance the Mouse Phenome Database (MPD) in response to emerging needs of the aging research community, specifically the ITP, to become a Data Coordinating Center (DCC) that curates ITP data, makes it available through a public database, and provides tools that enable users to visualize, analyze, and download the primary and summary data from these studies. Our objectives are to provide a central repository for data, documentation, and protocols, offering a unique and important venue for ITP investigators needing to make their data public; to continually refine and develop tools and features to best locate, present, and analyze those datasets; and to maintain, enhance, and promote this resource to further enable quantitative, standardized and predictive phenotype studies and, in turn facilitate new scientific advances in the field of aging. During the previous five years, we have designed a publicly accessible website and data repository for the ITP. We have also curated and posted data from numerous ITP studies. ITP plans for the next five years include additional lifespan trials, detailed analyses of agents found to increase lifespan, and continued growth in data on health outcomes. To help support these goals, our specific aims are to: 1) refine and maintain the current MPD-ITP website, 2) populate MPD with rigorously curated ITP data, 3) develop and extend the suite of MPD tools to support flexible analysis and visualization of ITP data, and 4) develop and maintain a publicly accessible database of ITP biospecimens available for external investigators to conduct their own studies in a collaborative manner. Completion of the proposed work for the ITP DCC will result in a powerful FAIR-compliant system (Findable, Accessible, Interoperable, and Reusable) for public access to and analysis of ITP data. This will help maximize the value of these data and provide the traceability and reproducibility required for extension and translation of the outcomes of ITP testing.