Mouse Phenome Database: NIA Interventions Testing Program Data Coordinating Center

小鼠表型组数据库：NIA 干预测试计划数据协调中心

• 批准号: 10207468
• 负责人: MOLLY A BOGUE
• 金额: $ 13.6万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-15 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10207468
• 关键词: Aging; Amino Acids; Animal Model; Architecture; Biological; Biological Specimen database; Biology of Aging; Chelating Agents; Collaborations; Collection; Communities; Complement; Computational Science; Data; Data Analyses; Data Coordinating Center; Data Set; Databases; Discipline; Disease; Documentation; Ensure; Environment; Evaluation; FAIR principles; Food; Foundations; Functional disorder; Genetic study; Genomics; Goals; Growth; Health; Hormones; Informatics; Intervention; Investigational Drugs; Knowledge; Laboratories; Longevity; Maintenance; Methods; Michigan; Modernization; Mollies; Mus; Nutraceutical; Outcome; Oxidation-Reduction; Pathology; Peptides; Pharmacologic Substance; Phenotype; Plant Extracts; Population; Population Heterogeneity; Predictive Value; Protocols documentation; Reproducibility; Research; Research Personnel; Research Project Grants; Resources; Scientific Advances and Accomplishments; Secure; Shock; Site; Software Engineering; Specimen; Standardization; System; Testing; Texas; The Jackson Laboratory; Translations; Universities; Visualization; Work; age related; bioinformatics resource; collaborative environment; data access; data management; data repository; data reuse; data tools; data visualization; design; dietary supplements; experience; flexibility; healthspan; implementation intervention; improved; insight; mouse genetics; normal aging; phenome; programs; public health relevance; repository; response; tool; web page; web portal; web site

PROJECT SUMMARY/ABSTRACT The NIA Interventions Testing Program (ITP) is a multi-institutional study investigating interventions with the potential to extend lifespan and delay disease or dysfunction in mice. Interventions are tested in parallel at three sites (The Jackson Laboratory, University of Michigan, and University of Texas) using identical standardized protocols. Such treatments include pharmaceuticals, nutraceuticals, foods, dietary supplements, plant extracts, hormones, peptides, amino acids, chelators, redox agents, and other compounds or mixtures of compounds. We propose to advance the Mouse Phenome Database (MPD) in response to emerging needs of the aging research community, specifically the ITP, to become a Data Coordinating Center (DCC) that curates ITP data, makes it available through a public database, and provides tools that enable users to visualize, analyze, and download the primary and summary data from these studies. Our objectives are to provide a central repository for data, documentation, and protocols, offering a unique and important venue for ITP investigators needing to make their data public; to continually refine and develop tools and features to best locate, present, and analyze those datasets; and to maintain, enhance, and promote this resource to further enable quantitative, standardized and predictive phenotype studies and, in turn facilitate new scientific advances in the field of aging. During the previous five years, we have designed a publicly accessible website and data repository for the ITP. We have also curated and posted data from numerous ITP studies. ITP plans for the next five years include additional lifespan trials, detailed analyses of agents found to increase lifespan, and continued growth in data on health outcomes. To help support these goals, our specific aims are to: 1) refine and maintain the current MPD-ITP website, 2) populate MPD with rigorously curated ITP data, 3) develop and extend the suite of MPD tools to support flexible analysis and visualization of ITP data, and 4) develop and maintain a publicly accessible database of ITP biospecimens available for external investigators to conduct their own studies in a collaborative manner. Completion of the proposed work for the ITP DCC will result in a powerful FAIR-compliant system (Findable, Accessible, Interoperable, and Reusable) for public access to and analysis of ITP data. This will help maximize the value of these data and provide the traceability and reproducibility required for extension and translation of the outcomes of ITP testing.

项目总结/摘要 NIA干预测试计划（ITP）是一项多机构研究，调查了 在小鼠中延长寿命和延迟疾病或功能障碍的潜力。干预措施的测试是平行的， 三个地点（密歇根大学杰克逊实验室和德克萨斯大学）使用相同的 标准化的协议。这些治疗包括药物、营养品、食品、膳食补充剂， 植物提取物、激素、肽、氨基酸、螯合剂、氧化还原剂和其它化合物或它们的混合物， 化合物.我们建议推进小鼠表型组数据库（MPD），以应对新出现的需求， 老龄化研究社区，特别是ITP，成为数据协调中心（DCC）， ITP数据，通过公共数据库提供，并提供使用户能够可视化的工具， 分析并下载这些研究的主要数据和汇总数据。我们的目标是提供一个 数据、文档和协议的中央存储库，为ITP提供独特而重要的场所 调查人员需要公开他们的数据;不断完善和开发工具和功能， 定位、展示和分析这些数据集;并维护、增强和推广这些资源，以进一步 实现定量、标准化和预测性表型研究，从而促进新的科学进步 在老龄化领域。在过去的五年里，我们设计了一个公开访问的网站和数据， ITP的存储库。我们还策划和发布了许多ITP研究的数据。ITP计划 未来五年包括额外的寿命试验，对发现的延长寿命的药物进行详细分析， 健康成果数据持续增长。为了帮助实现这些目标，我们的具体目标是：1）完善 并维护当前的MPD-ITP网站，2）用严格策划的ITP数据填充MPD，3）开发和 扩展MPD工具套件，以支持ITP数据的灵活分析和可视化，以及4）开发和 维护可供外部研究者进行ITP生物标本的公开访问数据库 以合作的方式进行自己的研究。在完成建议的主题公园发展控制中心工程后， 一个功能强大的符合FAIR标准的系统（可查找、可扩展、可互操作和可重用），供公众访问和 ITP数据分析。这将有助于最大限度地发挥这些数据的价值，并提供可追溯性， 扩展和翻译ITP检测结果所需的再现性。