Phenome Project

现象组计划

• 批准号: 7026488
• 负责人: MOLLY A BOGUE
• 金额: $ 33.01万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7026488
• 关键词: animal data; bioinformatics; computational biology; computer program /software; computer system design /evaluation; data collection methodology /evaluation; data quality /integrity; genetic polymorphism; genetic strain; genome; genotype; information retrieval; international cooperation; laboratory mouse; molecular biology information system; phenotype

DESCRIPTION (provided by applicant): Inbred strains of mice are a powerful tool for modeling human biology and disease. Exploiting this potential, however, requires comprehensive phenotypic data on multiple inbred strains. The Mouse Phenome Project is an international collaborative effort headquartered at The Jackson Laboratory (TJL) to promote the phenotypic and genotypic characterization of a set of inbred strains and their derivatives for a broad range of traits relevant to human disease and to make the data publicly available. Since its inception in 1999, with support from TJL institutional funds, pharmaceutical corporations, and research foundations, the Mouse Phenome Project has collected a significant amount of phenotypic and genotypic data on as many as 40 inbred strains and created a public database for maintaining, dispersing, and analyzing these data (Mouse Phenome Database; MPD). These resources are increasingly important to the biomedical research community, as reflected in the heavy use of the MPD and significant research advances using MPD phenotypic and SNP data for the inbred strains. The Mouse Phenome Project is now poised for a major expansion and seeks funding to support ongoing and expanded functions. Major projects planned include further promoting and coordinating collaborative efforts to generate comprehensive phenotypic and genotypic data on inbred strains and their derivatives; continuing to populate the MPD with quality-controlled phenotypic and SNP data, and posting haplotype maps on the MPD; developing enhanced and new tools for retrieval and analysis of MPD data; and enhancing community access to integrated information on mouse genetics and biology by coordinating MPD efforts with those of the Mouse Genome Informatics group at TJL. Expansion of the Mouse Phenome Project will allow the biomedical research community to continue to exploit these resources together with emerging sequence, SNP, and haplotype data to uncover new information on the biological and genetic factors participating in normal biological and disease pathways.

描述（由申请人提供）：近交系小鼠是模拟人类生物学和疾病的有力工具。然而，利用这种潜力需要多个近交系的全面表型数据。小鼠表型组项目是一项国际合作项目，总部位于杰克逊实验室 (TJL)，旨在促进一系列近交系及其衍生物的表型和基因型表征，以了解与人类疾病相关的广泛性状，并公开数据。自 1999 年启动以来，在 TJL 机构基金、制药公司和研究基金会的支持下，小鼠表型组项目已收集了多达 40 个近交系的大量表型和基因型数据，并创建了一个用于维护、分散和分析这些数据的公共数据库（小鼠表型组数据库；MPD）。这些资源对于生物医学研究界越来越重要，MPD 的大量使用以及使用 MPD 表型和 SNP 数据进行近交系数据的重大研究进展就反映了这一点。小鼠表型组项目现已准备好进行重大扩展，并寻求资金来支持正在进行的和扩展的功能。计划的主要项目包括进一步促进和协调合作努力，以生成自交系及其衍生物的全面表型和基因型数据；继续使用质量控制的表型和 SNP 数据填充 MPD，并在 MPD 上发布单倍型图谱；开发用于检索和分析 MPD 数据的增强型新工具；通过协调 MPD 的工作与 TJL 小鼠基因组信息学小组的工作，增强社区对小鼠遗传学和生物学综合信息的获取。小鼠表型组项目的扩展将使生物医学研究界能够继续利用这些资源以及新出现的序列、SNP 和单倍型数据，以发现有关参与正常生物和疾病途径的生物和遗传因素的新信息。