Training in the Epidemiology of Aging

项目摘要/摘要 这项关于匹兹堡大学培训计划在#年竞争性延续的提案 自1989年以来由NIA资助的老龄化流行病学研究重点是 衰老中的肌肉骨骼衰退和残疾。培训计划将包括3个预科 流行病学博士和2个博士后职位。我们丰富的多学科培训 环境根据每个受训人员的背景进行定制，以解决 老龄化研究，重点是尖端的生物学和生理学方法 流行病学，公共卫生研究和实践的核心学科。我们的专业人员 职业发展具有较强的沟通和分析方法，已培养出实习生 积极招聘到其他大学的博士后和教职员工职位， 政府和医疗保健。我们将继续培养下一代研究人员 通过有指导的、实践的、多样化的研究经验获得老龄化流行病学方面的专业人员 拥有该领域资金雄厚的领导者，以及正规课程。我们目标的新重点包括：1) 应用衰老和长寿生物学研究日常和加速的年龄相关 以肌肉、身体成分、活动能力和残疾为重点的生理变化； 骨质疏松症和骨关节炎；跌倒和跌倒伤害，与年龄有关的流行病学 功能衰退；2)推进老龄化流行病学和定量统计方法 以传统技术为基础，注重最新技术的学习；以及 在生物学专业领域采用多学科协作的方法进行流行病学研究 老龄化与长寿、卫生服务与多样性、健康公平与社会决定因素， 在确定预期寿命和预防中老年残疾的目标方面。至 开发实习生技能以领导调查人员发起的研究，我们将创建招聘和 测量核心。我们在这一领域有几项新的队列研究，包括对 肌肉、机动性和老龄化(Somma)，一组预期的、纵向的老年男性和 女性获取肌肉组织样本、生物标记物和先进的肌肉相关成像 活动障碍的风险和另一项与这些肌肉表型与骨骼相关的研究 来自高分辨率外围定量计算机断层扫描的参数。我们是一片田野 TAME，一项新的二甲双胍随机试验，用于减少与年龄相关的多发病和 功能衰退。我们的培训计划特别准备利用我们现有的和新的研究 在衰老的临床试验和纵向队列研究中阐明肌肉骨骼的途径 健康和身体功能，目的是预防老龄化人口中的残疾。

Project Summary/Abstract This proposal for the competing continuation of the University of Pittsburgh Training Program in the epidemiology of aging, funded by the NIA since 1989, is focused on the “Epidemiology of Musculoskeletal Decline and Disability in Aging.” The training program will include 3 pre- doctoral and 2 post-doctoral positions in epidemiology. Our rich multidisciplinary training environment is customized to the background of each trainee to address novel approaches in aging research with an emphasis on cutting-edge biological and physiological methods for epidemiology, a core discipline for research and practice in public health. Our professional career development for strong communication and analytic methods, has resulted in trainees that are actively recruited to postdoctoral and faculty positions within other universities, the government, and health care. We will continue to train the next generation of research professionals in aging epidemiology through mentored, hands-on, diverse research experiences with well-funded leaders in the field, and formal courses. The new focus of our Aims includes: 1) To apply the biology of aging and longevity to study usual and accelerated age-related physiologic change with focus in Muscle, Body Composition, Mobility, and Disability; Osteoporosis and Osteoarthritis; and Falls and Fall Injuries, for the epidemiology of age-related functional decline; 2) To advance epidemiologic and quantitative statistical methods in aging studies with a foundation in traditional skills and emphasis on state-of-art techniques; and 3) To use a multidisciplinary and collaborative approach to epidemiology for specialty areas of Biology of Aging and Longevity, Health Services, and Diversity, Health Equity and Social Determinants, in defining targets for active life expectancy and prevention of disability from mid- to late life. To develop trainee skills to lead investigator-initiated studies, we will create a Recruitment and Measurement Core. We have several new cohort studies in the field including the Study of Muscle, Mobility and Aging (SOMMA), a prospective, longitudinal cohort of older men and women to obtain muscle tissue samples, biomarkers and advanced imaging of muscle related to risk of mobility disability and another study to relate to these muscle phenotypes with bone parameters from high resolution peripheral quantitative computed tomography. We are a field site for TAME, a new randomized trial of metformin for reducing age-related multi-morbidity and functional decline. Our training program is uniquely poised to use our existing and new research in clinical trials and longitudinal cohort studies of aging to elucidate pathways of musculoskeletal health and physical function, with the goal of preventing disability in the aging population.