PET/MR Correlates of Accelerated Aging in Chronic Epilepsy

慢性癫痫加速衰老的 PET/MR 相关性

• 批准号: 10210072
• 负责人: Alan Blair McMillan
• 金额: $ 64.09万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-15 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10210072
• 关键词: Acceleration; Adopted; Affect; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease model; American; Amyloid beta-Protein; Angiography; Behavioral; Biological Markers; Blood Vessels; Body mass index; Brain; Categories; Chronic; Clinical; Cognition Disorders; Cognitive; Cognitive aging; Deposition; Disease remission; Education; Elderly; Epilepsy; Event; Exposure to; Family history of; Functional Magnetic Resonance Imaging; Gender; General Population; Genetic; Image; Insulin Resistance; Language; Lead; Lesion; Life Style; Lipids; Magnetic Resonance Imaging; Measures; Mediating; Medical; Memory; Metabolism; Methods; Modeling; Morphology; Myelin; Neurites; Neurologic; Outcome; Partial Epilepsies; Patients; Perfusion; Persons; Pharmaceutical Preparations; Physical Fitness; Population; Positron-Emission Tomography; Premature aging syndrome; Process; Proteins; Recording of previous events; Rest; Risk; Risk Factors; Seizures; Senile Plaques; Severities; Socioeconomic Status; Speed; Spin Labels; Statistical Models; Structure; Suggestion; Techniques; Temporal Lobe Epilepsy; Testing; Thick; abeta deposition; age related; aging brain; apolipoprotein E-4; base; brain metabolism; brain morphology; cerebral microbleeds; cohort; comorbidity; connectome; density; executive function; experience; fluorodeoxyglucose positron emission tomography; gray matter; imaging approach; imaging biomarker; interest; lifestyle factors; middle age; morphometry; nervous system disorder; neuroimaging; neuroimaging marker; novel; patient population; perfusion imaging; premature; protective factors; regional difference; resilience; sociodemographic factors; socioeconomics; therapy duration; white matter

Epilepsy affects more than 2 million Americans and is the fourth most common neurological disorder. While many patients experience long-term remission, lifelong chronic epilepsy is associated with cognitive, psychiatric, and somatic comorbidities and a well-characterized neuroimaging burden. Recently, there has been much interest and concern regarding disorders of cognitive and brain aging in the general population; however, there has been little systematic study of this issue in aging persons with chronic epilepsy. We hypothesize that prolonged exposure to epilepsy and its myriad of complications accelerate brain and cognitive aging. Specific Aim 1: Characterize biomarkers suggestive of accelerated brain aging in chronic focal epilepsy using advanced PET/MR methods. We hypothesize that PET/MR biomarkers sensitive to brain aging (e.g., increased beta amyloid deposition, morphological changes, changes in functional and structural connectivity, reduced microstructural integrity, reduced metabolism (FDG-PET), and reduced vascular integrity) will be greater in a cohort of chronic focal epilepsy patients compared to age-matched controls, and thus indicative of age-accelerated brain aging. Specific Aim 2: Characterize other risk and resilience factors for accelerated brain and cognitive aging biomarkers in chronic epilepsy. We hypothesize that age-related neuroimaging biomarkers will predict the presence and severity of cognitive abnormalities in patients with chronic focal epilepsy. Furthermore, we expect risk factors for poor cognitive outcome, including vascular, socioeconomic, and lifestyle to be more prevalent in epilepsy and related to age-related cognitive and neuroimaging biomarkers. Specific Aim 3: Identify the temporal sequence of biomarkers in chronic TLE that are indicative of brain and cognitive aging allowing us to model the mechanistic cascade that leads to accelerated aging. We will provide important new mechanistic evidence characterizing the consequences of chronic TLE on brain and cognitive aging and identify the specific neuroimaging and behavioral profiles, risk and resilience factors that may be protective (or detrimental) to the aging process.

癫痫影响着200多万美国人，是第四大最常见的神经系统疾病。而