Establishing The Validity, Responsiveness, And Appropriateness Of Patient-Reported Outcome Measures For Adult Traumatic Brachial Plexus Injury

确定成人创伤性臂丛神经损伤患者报告的结果测量的有效性、反应性和适当性

• 批准号: 10209232
• 负责人: Christopher John Dy
• 金额: $ 25.44万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-05 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10209232
• 关键词: Address; Adoption; Adult; Affect; Age; Americas; Attention; Biological; Brachial plexus structure; Characteristics; Clinical; Clinical Research; Cohort Studies; Comparative Study; Data Collection; Development; Direct Costs; Disease; Emotional; Employment; Enrollment; Esthesia; Event; Facilities and Administrative Costs; Family Caregiver; Financial Hardship; Future; Goals; Hand; Incidence; Injury; Interview; Lead; Life; Literature; Longitudinal Studies; Masks; Measures; Mental Health; Methodology; Muscle function; Muscular Atrophy; Nerve; Neurologic; Observational Study; Operative Surgical Procedures; Outcome; Outcome Assessment; Outcome Measure; Pain; Patient Outcomes Assessments; Patient-Focused Outcomes; Patients; Performance; Population; Predictive Factor; Prospective cohort study; Psychological Stress; Quality of life; Questionnaires; Recovery; Reporting; Research; Research Design; SF-36; Sample Size; Severities; Shoulder; Social support; Societies; Socioeconomic Status; Spinal Cord; Standardization; Subgroup; Surgeon; Surveys; Trauma; Unemployment; Upper Extremity; Validation; Work; arm; base; biomedical referral center; cohort; demographics; disability; economic implication; emotional trauma; experience; functional outcomes; improved; improved functioning; innovation; insight; instrument; member; metropolitan; patient oriented; patient population; physically handicapped; programs; prospective; reconstruction; social; treatment effect; treatment strategy; volunteer

PROJECT SUMMARY/ABSTRACT Adult traumatic brachial plexus injuries (BPI) have a devastating impact on patients, affecting multiple domains (physical, social, and emotional) of their lives. Prior studies have focused on neurologic and biologic predictors of severity of injury (such as extent of plexus injury), but little attention has been paid to other predictors of recovery. A better understanding of how other factors (such as emotional trauma, mental health, pain, and social support) influence recovery after BPI will provide new insight into ways to optimize outcomes for BPI patients. The long-term goal of our research program is to develop a national multicenter prospective cohort study of patients with BPI, assessing outcomes at standardized intervals using a patient-reported, disease-specific outcome measure that captures the physical and emotional domains of recovery. The objectives of this application are (1) to determine the outcome measures that best capture the experience of recovering from BPI and (2) to establish a framework of prospective multicenter data collection that can be expanded in the near future. We will use a prospective observational cohort study design, enrolling patients from five centers prior to surgical reconstruction for adult traumatic BPI. We will examine the criterion validity, responsiveness, and appropriateness of the DASH, SF-36, and a BPI-specific, patient-reported outcomes instrument that our group recently developed (“Impact of BPI” questionnaire). After we have completed the expected research, we will have a well-validated outcome measure for the BPI population along with the ability to define which surgical treatments provide meaningful improvement to patients.

项目摘要/摘要 成人创伤性臂丛神经损伤（BPI）对患者有毁灭性的影响，影响多个领域 （身体，社会和情感）的生活。以前的研究集中在神经和生物学预测 损伤的严重程度（如神经丛损伤的程度），但很少注意到其他的预测因素， 复苏更好地了解其他因素（如情感创伤，心理健康，疼痛和社会 支持）对BPI后恢复的影响将为BPI患者优化结局的方法提供新的见解。 我们研究计划的长期目标是开展一项全国多中心前瞻性队列研究， BPI患者，使用患者报告的疾病特异性 结果衡量，捕捉身体和情感领域的恢复。这一目标 应用程序是（1）确定最能反映从业务流程改进中恢复的经验的结果指标 和（2）建立一个可以在近期扩展的前瞻性多中心数据收集框架 未来我们将采用前瞻性观察性队列研究设计，从5个中心招募患者， 成人创伤性BPI外科重建我们将检查标准的有效性，反应性， DASH、SF-36和BPI特异性患者报告结局工具的适当性， 最近制定的（“公众宣传局的影响”调查表）。完成预期的研究后，我们将 对BPI人群有一个经过充分验证的结局指标，沿着有能力定义哪种手术 治疗为患者提供有意义的改善。