Establishing The Validity, Responsiveness, And Appropriateness Of Patient-Reported Outcome Measures For Adult Traumatic Brachial Plexus Injury

确定成人创伤性臂丛神经损伤患者报告的结果测量的有效性、反应性和适当性

• 批准号: 10613891
• 负责人: Christopher John Dy
• 金额: $ 18.45万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-05 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10613891
• 关键词: Address; Adoption; Adult; Affect; Age; Assessment tool; Attention; Biological; Brachial plexus structure; Caregivers; Characteristics; Clinical; Comparative Study; Data Collection; Development; Direct Costs; Disease; Emotional; Employment; Esthesia; Event; Facilities and Administrative Costs; Family; Financial Hardship; Frustration; Future; Goals; Hand; Incidence; Injury; Interview; Life; Literature; Masks; Measures; Mental Health; Methodology; Muscle function; Muscular Atrophy; Nerve; Neurologic; Observational Study; Operative Surgical Procedures; Outcome; Outcome Assessment; Outcome Measure; Pain; Patient Outcomes Assessments; Patient-Focused Outcomes; Patients; Performance; Population; Predictive Factor; Productivity; Prospective, cohort study; Psychological Stress; Quality of life; Questionnaires; Reconstructive Surgical Procedures; Recovery; Reporting; Research; Research Design; SF-36; Sample Size; Severities; Shoulder; Social support; Societies; Socioeconomic Status; Spinal Cord; Standardization; Subgroup; Surgeon; Surveys; Trauma; Unemployment; Upper Extremity; Validation; Work; arm; biomedical referral center; cohort; demographics; disability; economic implication; emotional trauma; experience; functional improvement; improved; innovation; insight; instrument; longitudinal, prospective study; member; metropolitan; observational cohort study; participant enrollment; patient oriented; patient population; physically handicapped; postoperative recovery; programs; prospective; social; treatment effect; treatment strategy; volunteer

PROJECT SUMMARY/ABSTRACT Adult traumatic brachial plexus injuries (BPI) have a devastating impact on patients, affecting multiple domains (physical, social, and emotional) of their lives. Prior studies have focused on neurologic and biologic predictors of severity of injury (such as extent of plexus injury), but little attention has been paid to other predictors of recovery. A better understanding of how other factors (such as emotional trauma, mental health, pain, and social support) influence recovery after BPI will provide new insight into ways to optimize outcomes for BPI patients. The long-term goal of our research program is to develop a national multicenter prospective cohort study of patients with BPI, assessing outcomes at standardized intervals using a patient-reported, disease-specific outcome measure that captures the physical and emotional domains of recovery. The objectives of this application are (1) to determine the outcome measures that best capture the experience of recovering from BPI and (2) to establish a framework of prospective multicenter data collection that can be expanded in the near future. We will use a prospective observational cohort study design, enrolling patients from five centers prior to surgical reconstruction for adult traumatic BPI. We will examine the criterion validity, responsiveness, and appropriateness of the DASH, SF-36, and a BPI-specific, patient-reported outcomes instrument that our group recently developed (“Impact of BPI” questionnaire). After we have completed the expected research, we will have a well-validated outcome measure for the BPI population along with the ability to define which surgical treatments provide meaningful improvement to patients.

项目摘要/摘要 成人创伤性臂丛神经损伤（BPI）对患者有毁灭性的影响，影响了多个领域 （身体，社会和情感）的生活。先前的研究集中于神经和生物学预测因子 受伤的严重程度（例如丛损伤程度），但很少有人注意其他预测因素 恢复。更好地了解其他因素（例如情绪创伤，心理健康，痛苦和社会）如何 支持）影响BPI之后的恢复将为优化BPI患者优化结果的方法提供新的见解。 我们研究计划的长期目标是开发一项国家多中心前瞻性队列研究 BPI患者，使用患者报告的特定于疾病的患者以标准化的间隔评估结果 捕获恢复的身体和情感领域的结果度量。目标的目标 应用程序是（1）确定最能捕获从BPI恢复的经验的结果指标 （2）建立一个预期的多中心数据收集框架，可以在附近扩展 未来。我们将使用前瞻性观察队列研究设计，在五个中心的患者中注册 成人创伤BPI的手术重建。我们将检查标准有效性，响应能力以及 仪表板，SF-36和BPI特定于患者报告的结果的适当性 最近开发的（“ BPI的影响”问卷）。完成预期的研究后，我们将 对BPI人群有一个充分的验证结果度量，并能够定义哪种手术 治疗为患者提供了有意义的改善。