Establishing The Validity, Responsiveness, And Appropriateness Of Patient-Reported Outcome Measures For Adult Traumatic Brachial Plexus Injury

确定成人创伤性臂丛神经损伤患者报告的结果测量的有效性、反应性和适当性

• 批准号: 10382337
• 负责人: Christopher John Dy
• 金额: $ 21.69万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-05 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10382337
• 关键词: Address; Adoption; Adult; Affect; Age; Americas; Attention; Biological; Brachial plexus structure; Characteristics; Clinical; Clinical Research; Cohort Studies; Comparative Study; Data Collection; Development; Direct Costs; Disease; Emotional; Employment; Enrollment; Esthesia; Event; Facilities and Administrative Costs; Family Caregiver; Financial Hardship; Future; Goals; Hand; Incidence; Injury; Interview; Lead; Life; Literature; Longitudinal Studies; Masks; Measures; Mental Health; Methodology; Muscle function; Muscular Atrophy; Nerve; Neurologic; Observational Study; Operative Surgical Procedures; Outcome; Outcome Assessment; Outcome Measure; Pain; Patient Outcomes Assessments; Patient-Focused Outcomes; Patients; Performance; Population; Predictive Factor; Prospective cohort study; Psychological Stress; Quality of life; Questionnaires; Recovery; Reporting; Research; Research Design; SF-36; Sample Size; Severities; Shoulder; Social support; Societies; Socioeconomic Status; Spinal Cord; Standardization; Subgroup; Surgeon; Surveys; Trauma; Unemployment; Upper Extremity; Validation; Work; arm; base; biomedical referral center; cohort; demographics; disability; economic implication; emotional trauma; experience; functional outcomes; improved; improved functioning; innovation; insight; instrument; member; metropolitan; patient oriented; patient population; physically handicapped; programs; prospective; reconstruction; social; treatment effect; treatment strategy; volunteer

PROJECT SUMMARY/ABSTRACT Adult traumatic brachial plexus injuries (BPI) have a devastating impact on patients, affecting multiple domains (physical, social, and emotional) of their lives. Prior studies have focused on neurologic and biologic predictors of severity of injury (such as extent of plexus injury), but little attention has been paid to other predictors of recovery. A better understanding of how other factors (such as emotional trauma, mental health, pain, and social support) influence recovery after BPI will provide new insight into ways to optimize outcomes for BPI patients. The long-term goal of our research program is to develop a national multicenter prospective cohort study of patients with BPI, assessing outcomes at standardized intervals using a patient-reported, disease-specific outcome measure that captures the physical and emotional domains of recovery. The objectives of this application are (1) to determine the outcome measures that best capture the experience of recovering from BPI and (2) to establish a framework of prospective multicenter data collection that can be expanded in the near future. We will use a prospective observational cohort study design, enrolling patients from five centers prior to surgical reconstruction for adult traumatic BPI. We will examine the criterion validity, responsiveness, and appropriateness of the DASH, SF-36, and a BPI-specific, patient-reported outcomes instrument that our group recently developed (“Impact of BPI” questionnaire). After we have completed the expected research, we will have a well-validated outcome measure for the BPI population along with the ability to define which surgical treatments provide meaningful improvement to patients.

项目摘要/摘要 成人外伤性臂丛神经损伤(BPI)对患者的影响是毁灭性的，涉及多个领域 (身体的、社交的和情感的)。此前的研究主要集中在神经学和生物学的预测因素上。 损伤的严重程度(如神经丛损伤的程度)，但对其他预测因素关注较少 恢复。更好地了解其他因素(如情感创伤、心理健康、痛苦和社交 支持)影响BPI后的康复将为优化BPI患者预后的方法提供新的见解。 我们研究计划的长期目标是发展一项全国性的多中心前瞻性队列研究 BPI患者，使用患者报告的特定疾病以标准化间隔评估结果 结果衡量标准，涵盖了康复的身体和情感领域。这样做的目的是 应用程序是(1)确定最能捕捉从BPI恢复的体验的结果衡量标准 (2)建立近期可扩展的前瞻性多中心数据采集框架 未来。我们将使用前瞻性观察队列研究设计，从五个中心招募患者，在 成人外伤性BPI的外科重建。我们将检查标准的有效性、响应性和 DASH、SF-36和BPI特定的、患者报告的结果工具的适当性 最近编制的(“公众宣传局的影响”问卷)。在我们完成预期的研究后，我们将 对BPI人群有一个经过验证的结果衡量标准，并有能力定义哪种手术 治疗为患者提供了有意义的改善。