Transcutaneous Direct Current Motor Nerve Block for Spasticity

经皮直流电机神经阻滞治疗痉挛

• 批准号: 10209321
• 负责人: Niloy Bhadra
• 金额: $ 40.21万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10209321
• 关键词: Action Potentials; Acute; Acute Pain; Affect; Axon; Caliber; Cerebral Palsy; Charge; Chemicals; Chronic; Clinical; Complication; Contracture; Data; Denervation; Development; Devices; Effectiveness; Electrodes; Electrolytes; Elements; Functional disorder; Future; Generations; Goals; Histology; Human; In Vitro; Injections; Interruption; Investigation; Ion Channel Gating; Local Anesthetics; Medical; Methods; Modality; Modeling; Monitor; Motor; Movement; Muscle; Muscle Hypertonia; Muscle Spasticity; Nerve; Nerve Block; Neural Conduction; Neurons; Operative Surgical Procedures; Oral; Oryctolagus cuniculus; Pathologic; Peripheral; Pharmaceutical Preparations; Pharmacology; Property; Rattus; Reaction; Recovery; Rehabilitation therapy; Rodent; Rodent Model; Safety; Short Interspersed Nucleotide Elements; Site; Skin; Spinal cord injury; Stroke; Surface; Temperature; Testing; Time; Tissues; Translating; Traumatic Brain Injury; Work; afferent nerve; autonomic nerve; base; channel blockers; chronic pain; chronic pain relief; clinical application; cost; design; disability; electric impedance; experimental study; flexibility; in vitro testing; in vivo; in vivo evaluation; innovation; limb movement; nerve damage; neurotransmission; nonhuman primate; novel; peroneal nerve; preclinical study; relating to nervous system; response; safety study; simulation; skin damage; skin irritation; spasticity; voltage

Uncoordinated or unwanted generation of nerve impulses is a major disabling factor in many medical conditions. These can affect motor, sensory, and autonomic nerves. Many of these pathological conditions could be ameliorated by interrupting these abnormal impulses in the periphery. The accepted methods of inhibiting neural activity are typically pharmacological (local anesthetics, oral medication, channel blockers, etc.) or surgical (denervation). Electrical nerve block has been proposed and evaluated as a means of providing real-time rapidly acting and rapidly reversing nerve block and is a potential candidate for inducing a reliable, rapid, gradable and reversible nerve block. Spasticity, or abnormally increased muscle tone, is a significant complication of stroke, cerebral palsy, spinal cord injury and traumatic brain injury. Spasticity causes significant disability including loss of movement, contractures and chronic pain. Electrical nerve block in the form of a non-invasive direct current block has been recently shown to produce motor block, when applied through the skin. This block has the properties of rapidity, reversibility and gradability, and repeatability. We propose an innovative direct current muscle block strategy delivered through the skin that will reduce spasticity and will aid in the rehabilitation of limb movement by reducing spasticity. The proposal focuses on development and testing of commercial and newly designed surface electrodes to show the efficacy of motor nerve block and investigate the parameters that deliver the direct current safely to both the skin and the target nerve.

神经冲动的不协调或不想要的产生是许多医疗中的主要致残因素。 条件这些可以影响运动，感觉和自主神经。许多这些病理状况 可以通过中断这些外围的异常脉冲来改善。公认的方法 抑制神经活性的药物通常是药理学的（局部麻醉剂，口服药物，通道阻滞剂， 等等）。或外科手术（去神经支配）。电神经阻滞已被提出和评估为一种手段， 提供实时快速作用和快速逆转的神经阻滞，并且是诱导神经阻滞的潜在候选者。 一种可靠、快速、可分级和可逆的神经阻滞。 痉挛，或异常增加的肌肉张力，是中风，脑瘫， 脊髓损伤和创伤性脑损伤。痉挛导致严重的残疾，包括运动丧失， 挛缩和慢性疼痛。非侵入性直流电阻滞形式的电神经阻滞具有 最近显示，当通过皮肤施用时，会产生运动阻滞。该块具有以下属性 快速性、可逆性、可分级性和可重复性。我们提出了一种创新的直流肌肉 通过皮肤传递的阻滞策略，将减少痉挛，并有助于肢体康复 运动通过减少痉挛。该提案的重点是开发和测试商业和新的 设计表面电极来显示运动神经阻滞的功效，并研究 将直流电安全地输送到皮肤和目标神经。