Transcutaneous Direct Current Motor Nerve Block for Spasticity

经皮直流电机神经阻滞治疗痉挛

• 批准号: 10378663
• 负责人: Niloy Bhadra
• 金额: $ 40.25万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10378663
• 关键词: Action Potentials; Acute; Acute Pain; Affect; Axon; Caliber; Cerebral Palsy; Charge; Chronic; Clinical; Complication; Contracture; Data; Denervation; Development; Devices; Effectiveness; Electrodes; Electrolytes; Elements; Functional disorder; Future; Generations; Goals; Histology; Human; In Vitro; Injections; Interruption; Investigation; Ion Channel Gating; Local Anesthetics; Medical; Methods; Modality; Modeling; Monitor; Motor; Movement; Muscle; Muscle Hypertonia; Muscle Spasticity; Nerve; Nerve Block; Neural Conduction; Neurons; Operative Surgical Procedures; Oral; Oryctolagus cuniculus; Pathologic; Peripheral; Pharmaceutical Preparations; Pharmacology; Property; Rattus; Reaction; Recovery; Rehabilitation therapy; Rodent; Rodent Model; Safety; Short Interspersed Nucleotide Elements; Site; Skin; Spinal cord injury; Stroke; Surface; Temperature; Testing; Time; Tissues; Translating; Traumatic Brain Injury; Work; afferent nerve; autonomic nerve; base; channel blockers; chronic pain; chronic pain relief; clinical application; cost; design; disability; electric impedance; experimental study; flexibility; in vitro testing; in vivo; in vivo evaluation; innovation; limb movement; nerve damage; neurotransmission; nonhuman primate; novel; peroneal nerve; preclinical study; relating to nervous system; response; safety study; simulation; skin damage; skin irritation; spasticity; voltage

Uncoordinated or unwanted generation of nerve impulses is a major disabling factor in many medical conditions. These can affect motor, sensory, and autonomic nerves. Many of these pathological conditions could be ameliorated by interrupting these abnormal impulses in the periphery. The accepted methods of inhibiting neural activity are typically pharmacological (local anesthetics, oral medication, channel blockers, etc.) or surgical (denervation). Electrical nerve block has been proposed and evaluated as a means of providing real-time rapidly acting and rapidly reversing nerve block and is a potential candidate for inducing a reliable, rapid, gradable and reversible nerve block. Spasticity, or abnormally increased muscle tone, is a significant complication of stroke, cerebral palsy, spinal cord injury and traumatic brain injury. Spasticity causes significant disability including loss of movement, contractures and chronic pain. Electrical nerve block in the form of a non-invasive direct current block has been recently shown to produce motor block, when applied through the skin. This block has the properties of rapidity, reversibility and gradability, and repeatability. We propose an innovative direct current muscle block strategy delivered through the skin that will reduce spasticity and will aid in the rehabilitation of limb movement by reducing spasticity. The proposal focuses on development and testing of commercial and newly designed surface electrodes to show the efficacy of motor nerve block and investigate the parameters that deliver the direct current safely to both the skin and the target nerve.

不协调或不想要的神经冲动的产生是许多医学中的主要致残因素 条件。它们会影响运动神经、感觉神经和自主神经。这些病理情况中的许多 可以通过阻断这些外周的异常冲动而得到改善。被接受的方法 抑制神经活动通常是药理学的(局麻药、口服药物、通道阻滞剂、 等)或外科手术(去神经)。电神经阻滞已被提出并作为一种手段进行评估 提供实时、快速起效和快速逆转的神经阻滞，是一种潜在的诱导 一种可靠、快速、分级、可逆的神经阻滞。 痉挛，或肌肉张力异常增加，是中风、脑瘫、 脊髓损伤和创伤性脑损伤。痉挛会导致严重的残疾，包括行动不便， 痉挛和慢性疼痛。非侵入性直流电阻滞形式的电神经阻滞具有 最近有研究表明，当通过皮肤涂抹时，可以产生运动块。此块具有以下属性 具有快速性、可逆性、可分级性和可重复性。我们提出了一种创新的直流电肌肉 通过皮肤传递的阻断策略将减少痉挛并有助于肢体的康复 通过减少痉挛来运动。该提案的重点是开发和测试商业和新的 设计了显示运动神经阻滞效果的表面电极，并考察了 将直流电安全地输送到皮肤和靶神经。