Combined No Onset Waveform for KiloHertz Frequency Alternating Current Nerve Block

千赫兹频率交流神经阻滞的组合无起始波形

• 批准号: 9367261
• 负责人: Niloy Bhadra
• 金额: $ 45.93万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2021-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9367261
• 关键词: Action Potentials; Acute; Adverse effects; Affect; Animal Experiments; Canis familiaris; Cardiac; Cavia; Charge; Chemicals; Clinical; Computer Simulation; Computer software; Computers; Denervation; Disease; Effectiveness; Electrodes; Equilibrium; Frequencies; Future; Generations; Goals; Interruption; Local Anesthetics; Lung; Medical; Methods; Modeling; Motor; Muscle Spasticity; Names; Nerve; Nerve Block; Neural Conduction; Neurons; Operative Surgical Procedures; Pathologic; Pathology; Peripheral Nerves; Peripheral Nervous System; Peripheral Nervous System Diseases; Pharmacology; Property; Ramp; Research; Rodent Model; Sensory; System; Testing; Time; afferent nerve; autonomic nerve; base; channel blockers; clinical application; clinically relevant; design; experimental study; in vivo; innovation; millisecond; preclinical study; prototype; relating to nervous system; response; simulation; success; sural

Uncoordinated or unwanted generation of nerve impulses is a major disabling factor in many medical conditions. These can affect motor, sensory, and autonomic nerves. Many of these pathological conditions could be ameliorated by interrupting these abnormal impulses in the periphery. The accepted methods of inhibiting neural activity are typically pharmacological (local anesthetics, channel blockers, etc.) or surgical (denervation). Electrical nerve block has been proposed and evaluated as a means of providing real-time rapidly acting and rapidly reversing nerve block and is a potential candidate for inducing a reliable, rapid, gradable and reversible nerve block. We have been investigating two types of electrical nerve block; KiloHertz Frequency Alternating Current (KHFAC) and Charge Balance Polarizing Current (CBPC) nerve block for clinical applications. KHFAC produces a rapid and reversible block. However, it has an important side effect. It produces an onset response when first initiated. This onset response is a brief rapid activation of the nerve and is a detriment to generalized clinical applications. CBPC block does not produce an onset response but can only be applied up to 10 seconds at a time with a low duty cycle. We have combined the positive aspects of the two methods of electrical nerve block into a single waveform (Combined No Onset Waveform or CNOW). We propose to investigate and optimize the design of the CNOW through computer simulations, hardware design and animal experiments to finalize a reliable method of applying KHFAC nerve block, without an onset response, in a variety of clinically relevant peripheral nerves.

在许多人中，不协调或不必要的神经冲动是许多主要的残疾因素 医疗状况。这些会影响运动，感觉和自主神经。这些病理中的许多 可以通过中断外围的这些异常冲动来改善条件。接受的 抑制神经活动的方法通常是药理（局部麻醉，通道阻滞剂等） 或手术（神经支配）。已经提出并评估电神经阻滞作为提供的一种手段 实时迅速发挥作用并迅速逆转神经阻滞，是诱导可靠， 快速，可分析和可逆的神经阻滞。我们一直在研究两种类型的电神经阻滞。 Kilohertz频率交流电流（KHFAC）和电荷平衡极化电流（CBPC）神经 用于临床应用的阻滞。 KHFAC产生了快速且可逆的区块。但是，它具有重要的副作用。它产生 首次发起时的发作响应。这种开始反应是神经的短暂快速激活，是 不利于广义临床应用。 CBPC块不会产生发作响应，但只能 一次以低占空比周期施加最多10秒。我们结合了积极的方面 两种电神经块的方法成单个波形（合并不发动波形或CNOW）。 我们建议通过计算机模拟，硬件调查和优化CNOW的设计 设计和动物实验，以最终确定应用KHFAC神经阻滞的可靠方法 发作反应，在各种临床相关的周围神经中。