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Combined No Onset Waveform for KiloHertz Frequency Alternating Current Nerve Block

千赫兹频率交流神经阻滞的组合无起始波形

基本信息

批准号：
9926876
负责人：
Niloy Bhadra
金额：
$ 62.67万
依托单位：
CASE WESTERN RESERVE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-08-01 至 2022-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9926876
关键词：
Action Potentials Acute Affect Animal Experiments Canis familiaris Cardiac Cavia Charge Chemicals Clinical Computer Simulation Computer software Computers Denervation Disease Electrodes Equilibrium Frequencies Future Generations Goals Interruption Local Anesthetics Lung Medical Methods Modeling Motor Muscle Spasticity Names Nerve Nerve Block Neural Conduction Neurons Operative Surgical Procedures Pathologic Pathology Peripheral Nerves Peripheral Nervous System Peripheral Nervous System Diseases Pharmacology Property Ramp Research Rodent Model Sensory System Testing Time afferent nerve autonomic nerve base channel blockers clinical application clinically relevant design effectiveness evaluation experimental study in vivo innovation millisecond preclinical study prototype relating to nervous system response side effect simulation success sural

项目摘要

Uncoordinated or unwanted generation of nerve impulses is a major disabling factor in many medical conditions. These can affect motor, sensory, and autonomic nerves. Many of these pathological conditions could be ameliorated by interrupting these abnormal impulses in the periphery. The accepted methods of inhibiting neural activity are typically pharmacological (local anesthetics, channel blockers, etc.) or surgical (denervation). Electrical nerve block has been proposed and evaluated as a means of providing real-time rapidly acting and rapidly reversing nerve block and is a potential candidate for inducing a reliable, rapid, gradable and reversible nerve block. We have been investigating two types of electrical nerve block; KiloHertz Frequency Alternating Current (KHFAC) and Charge Balance Polarizing Current (CBPC) nerve block for clinical applications. KHFAC produces a rapid and reversible block. However, it has an important side effect. It produces an onset response when first initiated. This onset response is a brief rapid activation of the nerve and is a detriment to generalized clinical applications. CBPC block does not produce an onset response but can only be applied up to 10 seconds at a time with a low duty cycle. We have combined the positive aspects of the two methods of electrical nerve block into a single waveform (Combined No Onset Waveform or CNOW). We propose to investigate and optimize the design of the CNOW through computer simulations, hardware design and animal experiments to finalize a reliable method of applying KHFAC nerve block, without an onset response, in a variety of clinically relevant peripheral nerves.

不协调或不想要的神经冲动的产生是许多疾病的主要致残因素医疗条件。它们会影响运动神经、感觉神经和自主神经。其中许多病态的通过阻断外围设备的这些异常冲动，情况可能会有所改善。被接受的人抑制神经活动的方法通常是药理学的(局麻药、通道阻滞剂等)。或外科手术(去神经)。电神经阻滞已经被提出并被评估为一种提供实时快速作用和快速逆转神经阻滞，是一种潜在的候选诱导可靠的，快速、分级、可逆性神经阻滞。我们一直在研究两种类型的电神经阻滞；千赫交流电与电荷平衡极化电流神经用于临床应用的块。 KHFAC生产一种快速和可逆的块。然而，它有一个重要的副作用。它生产第一次启动时的起效反应。这种起效反应是一种短暂的神经快速激活，是一种不利于广泛的临床应用。CBPC阻断不会产生起效反应，但只能在低占空比的情况下，一次施加最多10秒。我们结合了两种方法电神经阻滞成单一波形(联合无起始波或CNOW)。我们建议通过计算机模拟、硬件来研究和优化CNOW的设计设计和动物实验以确定一种可靠的应用KHFAC神经阻滞的方法，而不需要起病反应，在各种临床相关的周围神经中。