Sleep Enhancement to Decrease Blood Pressure: A Randomized, Controlled Trial

增强睡眠以降低血压：一项随机对照试验

• 批准号: 10210282
• 负责人: Virend K Somers
• 金额: $ 77.27万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-20 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10210282
• 关键词: Adipose tissue; Adult; Affect; Aftercare; Aldosterone; Angiotensin II; Angiotensins; Antihypertensive Agents; Baroreflex; Behavior Therapy; Behavioral; Blood Pressure; Blood Vessels; Cardiovascular Diseases; Cardiovascular system; Cerebrovascular Disorders; Chronic; Complement; Complex; Corticotropin; Data; Development; Education; Educational Intervention; Elements; Endothelium; Equilibrium; Etiology; Health; Health Benefit; Health Hazards; Health Promotion; Health Status; Health education; Healthcare; Hormonal; Hour; Hydrocortisone; Hypertension; Insulin; Intervention; Life Style; Link; Longitudinal Studies; Maintenance; Measures; Mediator of activation protein; Metabolic; Metabolism; Modernization; Molecular; Neurosecretory Systems; Partner in relationship; Physiological; Placebos; Play; Population; Prevalence; Probability; Public Health; Randomized; Randomized Controlled Trials; Regulation; Renin; Renin-Angiotensin-Aldosterone System; Reporting; Research Design; Research Personnel; Risk; Sleep; Sleep Deprivation; Societies; Testing; Vasoconstrictor Agents; Vasodilator Agents; Visceral fat; arm; attentional control; blood glucose regulation; blood pressure reduction; blood pressure regulation; cardiovascular health; cardiovascular risk factor; care burden; cost; diabetes risk; efficacy study; experience; follow-up; group intervention; hormone regulation; improved; insight; molecular phenotype; mortality risk; psychologic; randomized controlled study; relating to nervous system; response; risk stratification

Project Summary/Abstract Hypertension is the major risk factor for cardiovascular and cerebrovascular diseases worldwide. The escalating prevalence of inadequate sleep now parallels that of hypertension. Observational and experimental evidence favoring a causal relation between insufficient sleep and hypertension are particularly compelling - sleeping 6 hours or less per night is associated with a 20-32% higher probability of incident hypertension. Since sleep curtailment is largely voluntary, sleep deficiency may be corrected and the detrimental health consequences potentially reversed. Nevertheless, systematic studies and robust evidence of health-promoting effects of sleep enhancement are lacking, and there are no data regarding the underlying mechanisms that may be involved, especially with regard to blood pressure (BP) control. We seek to overcome these limitations by conducting a randomized controlled study to investigate the effects of 8 weeks of sleep enhancement/extension in prehypertensive and stage 1 hypertensive subjects who report habitual short sleep (<6.5 hours/night). Antihypertensive effects of sleep enhancement achieved through education and behavioral intervention will be compared to a placebo/attention control condition receiving health education. Comprehensive measures, including cardiovascular, metabolic and neuroendocrine markers, complemented by molecular phenotyping and psychological characterization, will generate insights into the mechanisms and mediators linking enhanced sleep to any BP reduction, and to any overall improved cardiovascular risk profile. We propose the following Specific Aims comparing sleep enhancement/extension to placebo/attention control: Aim 1. To determine the impact of sleep enhancement on 24-hour BP. Aim 2. To evaluate effects of sleep enhancement on neural circulatory control and vascular function. Aim 3. To assess changes in systemic and local renin-angiotensin-aldosterone system (RAAS) regulation in response to sleep enhancement. Aim 4. To identify metabolic and neuroendocrine mediators of the effects of sleep enhancement on BP. This proposal builds upon important strengths, including an interdisciplinary team of investigators with unique experience and expertise in each of the domains investigated, exciting preliminary data, and the minimization of potential confounders. The integration of physiological and molecular variables in a translational framework, complemented by psychological and behavioral characterization, will further bolster the proposed study. Data from these studies will be pivotal in the development and implementation of effective, low cost, health promoting sleep extension strategies applicable both on a targeted and a population-wide basis.

项目总结/文摘

项目成果

From Resistant Airway to Resistant Hypertension.

从抵抗气道到抵抗性高血压。

• DOI: 10.1161/circulationaha.118.038591
• 发表时间: 2019
• 期刊: Circulation
• 影响因子: 37.8
• 作者: Covassin,Naima;Somers,VirendK
• 通讯作者: Somers,VirendK

Disparities in Hypertension Among African-Americans: Implications of Insufficient Sleep.

• DOI: 10.1007/s11906-018-0855-1
• 发表时间: 2018-06-08
• 期刊: Current hypertension reports
• 影响因子: 5.6
• 作者: Covassin N;Greene EL;Singh P;Somers VK
• 通讯作者: Somers VK

Experimental Weight Gain Increases Ambulatory Blood Pressure in Healthy Subjects: Implications of Visceral Fat Accumulation.

• DOI: 10.1016/j.mayocp.2017.12.012
• 发表时间: 2018-05
• 期刊: Mayo Clinic proceedings
• 影响因子: 8.9
• 作者: Covassin N;Sert-Kuniyoshi FH;Singh P;Romero-Corral A;Davison DE;Lopez-Jimenez F;Jensen MD;Somers VK
• 通讯作者: Somers VK

Objective but Not Subjective Short Sleep Duration Is Associated With Hypertension in Obstructive Sleep Apnea.

客观而非主观的睡眠时间短与阻塞性睡眠呼吸暂停的高血压相关

• DOI: 10.1161/hypertensionaha.118.11027
• 发表时间: 2018-09
• 期刊: Hypertension (Dallas, Tex. : 1979)
• 作者: Ren R;Covassin N;Yang L;Li Y;Zhang Y;Zhou J;Tan L;Li T;Li X;Wang Y;Zhang J;Wing YK;Li W;Somers VK;Tang X
• 通讯作者: Tang X