Interactions Between Obesity Risk and Insufficient Sleep

肥胖风险与睡眠不足之间的相互作用

• 批准号: 8656426
• 负责人: Virend K Somers
• 金额: $ 68.44万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8656426
• 关键词: Acclimatization; Acute; Address; Adipocytes; Adult; Basal metabolic rate; Behavioral; Biopsy; Body Composition; Body Weight; Body Weight decreased; Body fat; Body mass index; Cardiovascular Diseases; Chronic; Clinical; Clinical Research; Comorbidity; Conflict (Psychology); Consumption; Cross-Over Studies; Data; Dose; Eating; Energy Intake; Energy Metabolism; Epidemic; Esthesia; Evaluation; Experimental Models; Fatty acid glycerol esters; Food; Future; General Population; Genetic Crossing Over; Health; Homeostasis; Hormones; Hour; Human; Human body; Hunger; Lead; Leptin; Life; Link; Measurement; Measures; Metabolic; Metabolic Diseases; Metabolic syndrome; Metabolism; Monitor; Morbidity - disease rate; Neurohormones; Neurosecretory Systems; Obesity; Play; Polysomnography; Population; Population Study; Prevalence; Prospective Studies; Protocols documentation; Randomized; Recovery; Regulation; Reporting; Research; Risk; Series; Signal Transduction; Sleep; Sleep Deprivation; Societies; Staging; System; Techniques; Testing; Time; Wakefulness; Weight; Weight Gain; Woman; adipocyte biology; age group; energy balance; falls; ghrelin; insight; men; novel; obesity prevention; obesity risk; programs; research study; response; translational study; young adult

DESCRIPTION (provided by applicant): The demands of present day living have placed a premium on time. Voluntary sleep curtailment is endemic and many adults typically sleep an average of six hours per night. Observational data suggest that short sleep duration is associated with a greater likelihood of being obese. Low grade chronic sleep deprivation may constitute an important and potentially correctable behavioral factor in the alarming increase in obesity. There are no definitive experimental studies in humans showing whether insufficient sleep indeed contributes to increased energy intake, changes in energy expenditure, and an increase in fat mass. We propose a series of novel studies to investigate abnormalities in energy homeostasis imparted by sleep restriction. These studies combine state-of-the-art techniques for monitoring sleep, food intake, energy expenditure, neuroendocrine energy regulation, body composition, and translational studies of adipocyte biology in humans. We will measure food intake, energy expenditure (basal metabolic rate, thermic effect of food, and activity), neurohormone levels, body fat content, and obtain fat biopsies for studies of adipocytes, in healthy subjects with normal BMI (20-25 kg/m2). Eighteen subjects (9 men and 9 women) will be randomized to a cross-over protocol of sleep restriction. After a 4 day baseline evaluation, these subjects will undergo 14 days of modest sleep restriction or a control period followed by a 3 day recovery period. Measurements during sleep restriction will be compared to those obtained while randomized to the control session. Sleep restriction and control sessions will undergo similar monitoring and measurements in the Clinical Research Unit over the same duration. We will test the following hypotheses: 1. that sleep restriction results in increased caloric intake 2. That sleep restriction does not change energy expenditure 3. That sleeps restriction results in a positive energy balance and increased fat mass 4. That sleep restriction results in changes in adipocyte biology that lead to impaired leptin signaling Our proposal builds on established research programs and compelling preliminary data addressing first, neuroendocrine mechanisms in sleep and obesity, and second, the regulation of energy intake and energy expenditure in humans. These studies will provide pivotal insights into whether sleep restriction promotes increased food intake and/or reduced activity levels, and increased fat mass, and into the mechanisms by which sleep interacts with energy balance and obesity risk.

描述（由申请人提供）：当今生活的需求已按时溢价。自愿睡眠减少是地方性的，许多成年人通常每晚平均睡6个小时。观察数据表明，短睡眠持续时间与肥胖的可能性更大有关。低年级的慢性睡眠剥夺可能构成肥胖症令人震惊的重要行为因素。在人类中没有明确的实验研究表明，睡眠不足是否确实有助于增加能量摄入，能量消耗的变化和脂肪质量增加。我们提出了一系列新型研究，以研究通过睡眠限制赋予能量稳态异常的异常。这些研究结合了监测睡眠，食物摄入，能量消耗，神经内分泌能量调节，人体组成以及人类脂肪细胞生物学的翻译研究的最新技术。我们将测量食物摄入量，能量消耗（基础代谢率，食物的热效应和活动），神经激素水平，体内脂肪含量以及获得正常BMI（20-25 kg/m2）健康受试者的脂肪细胞研究的脂肪活检。 18名受试者（9名男性和9名女性）将被随机分为跨越的睡眠限制方案。经过4天的基线评估后，这些受试者将接受14天的适度睡眠限制或控制期，然后进行3天的恢复期。将睡眠限制期间的测量与随机分配到对照课程时获得的测量。睡眠限制和控制会议将在同一持续时间内进行临床研究单元的相似监测和测量。我们将测试以下假设：1。睡眠限制会导致热量摄入量增加2。睡眠限制不会改变能量支出3。睡眠限制会导致能量平衡并增加脂肪质量4。该睡眠限制导致脂肪细胞生物学的变化，导致瘦素信号促进我们的瘦素机制，该机制在固定的研究方面和促成的依据，并构建了依据的依据，并构成了促成的数据，并构成了数据，并构成了促进的数据，并构成了序列性的数据，并构成了系统的数据，并将其构成序列化的系统，并构成了序列性的数据。肥胖，其次是人类能量摄入和能量消耗的调节。这些研究将提供有关睡眠限制是否促进食物摄入量和/或降低活性水平，脂肪质量增加以及睡眠与能量平衡和肥胖风险相互作用的机制的关键见解。