Metallosupramolecular Cages for Enantioselective Applications

用于对映选择性应用的金属超分子笼

• 批准号: DP210100374
• 负责人: A/Prof David Turner
• 金额: $ 14.7万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-02-22 至 2024-04-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210100374
• 关键词: Metallosupramolecular; Cages; Enantioselective; Applications

The project aims to explore new synthetic routes to functional supramolecular cages/containers which are able to selectively host small molecules in their interior space, and may provide feedback upon the presence of a guest (i.e. molecular sensing) or catalyse reactions within the enclosed cavity. The project expects to produce chiral cages that are capable of detecting specific enantiomers in solution and act upon them. The expected outcome is a deeper understanding of the structure/property relationship of these novel species and steps towards application. This should provide benefits given the application of solution-based methods for enantioselective sensing/catalysis are of significance in high-value pharmaceutical synthesis.

该项目旨在探索功能性超分子笼/容器的新合成路线，这些笼/容器能够在其内部空间选择性地容纳小分子，并可以对客体的存在提供反馈（即分子传感）或催化封闭腔内的反应。该项目预计生产出能够检测溶液中特定对映体并对其起作用的手性笼。预期的结果是对这些新物种的结构/性质关系和应用步骤有更深入的了解。鉴于基于溶液的对映选择性传感/催化方法的应用在高价值药物合成中具有重要意义，这应该会带来好处。