Vivarium Modernization with Digital Ventilated Cages to Enhance Research Capacity and Reproducibility, and Provide Cage Environment Monitoring for Improved Operational Efficiency and Animal Welfare
采用数字通风笼进行现代化改造,以提高研究能力和再现性,并提供笼环境监测,以提高运营效率和动物福利
基本信息
- 批准号:10533591
- 负责人:
- 金额:$ 40万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-01 至 2023-07-31
- 项目状态:已结题
- 来源:
- 关键词:2019-nCoV5 year oldAddressAdministratorAgingAirAir MovementsAnimal ExperimentationAnimal HousingAnimal ModelAnimal WelfareAnimalsBiomedical ResearchCensusesCommunicable DiseasesCommunitiesComputer softwareContainmentDataDisciplineElectronicsEngineeringEnsureEnvironmentEquipmentFoodFundingFutureGeneral PracticesGoalsHealthHomeHousingHumanHuman ResourcesHumidityIndividualInfectious AgentInfectious Diseases ResearchInterventionInvestmentsKAI1 geneLaboratory Animal Production and FacilitiesLightingLymphocytic choriomeningitis virusModernizationMonitorNoisePersonal SatisfactionPowassan virusProcessPublicationsRabiesReportingReproducibilityResearchResearch PersonnelResearch SupportRisk ReductionRodentScheduleScienceSecureServicesSevere Acute Respiratory SyndromeSpecimen HandlingStandardizationStrategic PlanningStressSystemTemperatureTimeTissue SampleUniversitiesUpdateVacciniaVariantWaterWorkanimal careanimal dataanimal facilitybasebiosecuritycoronavirus diseasedetection platformdigitalexperimental studyhigh efficiency particulate air filterhumane endpointimprovedinfluenzavirusmeetingsoperationpathogenprogramsresearch studyresponsesample collectionsensortissue processingventilationvibration
项目摘要
ABSTRACT
We are seeking support to purchase and install an integrated digital ventilated cage system to
enhance operational efficacy and modernize and strengthen the research-supporting operations of an
existing, more than twenty-five-year-old shared-use ABSL3 facility. This FOA is timely, since the
addition of the integrated Digital Ventilated Cage (DVC®) system we are requesting would synergize
with our ongoing institutional strategic plan to modernize existing vivarium facilities, and have broad
benefits for the institutional research community. The static microisolator caging system currently in
use is suboptimal and antiquated and cannot meet the current or future needs of the large number of
investigators from different disciplines performing ABSL3 work with animals infected with SAR2-Covid,
SARS-Covid variants and other BL3 agents. The DVC® is a unique and revolutionary home-cage
monitoring system composed of a mix of electronics and software components to collect a set of
information directly from the home cage. We selected this system with the goals of 1) improving the
shared-use facility operational efficiency and 2) enhancing animal welfare management. Furthermore,
3) the unique detection system collects extrinsic environmental conditions
(temperature, humidity, noise and vibration, human intervention, etc.) in the home cages. These
factors are likely to have effects on experiments using animals and reporting them in publications as a
general practice could contribute to improved research quality (rigor and reproducibility). The
modernization of an outdated ABSL3 facility to a more secure one containing a state-of-the-art
integrated digital ventilated cage system in two animal housing rooms. This equipment modernization
will combine and potentially synergize with institutionally-funded modernization efforts slated to be
completed within the next six months – for example, the modernized animal housing caging system
will be located in rooms adjacent to and with direct access to a modernized BL3 suite for tissue
processing and specimen processing. Therefore, our proposed equipment modernization is a critical
step towards meeting the needs of current and future investigators from diverse disciplines using
rodent animal models for research involving an increasing number of BL3 pathogens.
摘要
我们正在寻求购买和安装集成数字通风笼系统的支持,
提高业务效率,加强研究支持业务并使之现代化,
现有的,超过25岁的共享使用ABSL 3设施。这是及时的,因为
增加我们要求的集成数字通风笼(DVC®)系统将协同
我们正在进行的机构战略计划,以现代化现有的饲养设施,并有广泛的
对研究机构的好处。静态微隔离器笼系统目前在
使用是次优和过时的,不能满足目前或未来的需要,大量的
来自不同学科的研究人员对感染SAR 2-Covid的动物进行ABSL 3工作,
SARS-Covid变体和其他BL 3制剂。DVC®是一种独特的革命性家用笼
监测系统由电子和软件组件的混合组成,以收集一组
直接从笼子里获取信息我们选择这个系统的目标是:1)提高
共享设施的运营效率和2)加强动物福利管理。此外,委员会认为,
3)独特的检测系统收集外部环境条件
(温度、湿度、噪声和振动、人为干预等)在家里的笼子里这些
这些因素可能对使用动物的实验产生影响,并在出版物中将其报告为
一般做法可有助于提高研究质量(严谨性和可重复性)。的
将一个过时的ABSL 3设施现代化,使其成为一个更安全的设施,
两个动物饲养室中的集成数字通风笼系统。设备现代化
将联合收割机与机构资助的现代化努力结合起来,并可能产生协同作用,
在接下来的六个月内完成-例如,现代化的动物圈养系统
将位于与现代化BL 3组织套件相邻并可直接进入的房间内
处理和标本处理。因此,我们提出的设备现代化是一个关键
为满足来自不同学科的当前和未来调查人员的需求,
啮齿类动物模型用于研究,涉及越来越多的BL 3病原体。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Theodore F Taraschi其他文献
Theodore F Taraschi的其他文献
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{{ truncateString('Theodore F Taraschi', 18)}}的其他基金
Evaluation of Small Molecule Inhibitors of Hemoglobin Transport as Antimalarials
血红蛋白转运小分子抑制剂作为抗疟药的评价
- 批准号:
8114424 - 财政年份:2011
- 资助金额:
$ 40万 - 项目类别:
Evaluation of Small Molecule Inhibitors of Hemoglobin Transport as Antimalarials
血红蛋白转运小分子抑制剂作为抗疟药的评价
- 批准号:
8320098 - 财政年份:2011
- 资助金额:
$ 40万 - 项目类别:
CYTOSTOME-FOOD VACUOLE INTERACTIONS IN PLASMODIUM FALCIPARUM
恶性疟原虫中细胞造口术-食物泡的相互作用
- 批准号:
8172288 - 财政年份:2010
- 资助金额:
$ 40万 - 项目类别:
CORE--MAGNETIC RESONANCE AND ELECTRON SPIN RESONANCE FACILITY
核心——磁共振和电子自旋共振装置
- 批准号:
6563163 - 财政年份:2001
- 资助金额:
$ 40万 - 项目类别:
DNA BASE EXCISION REPAIR IN PLASMODIUM FALCIPARUM
恶性疟原虫 DNA 碱基切除修复
- 批准号:
6704235 - 财政年份:2001
- 资助金额:
$ 40万 - 项目类别:
DNA BASE EXCISION REPAIR IN PLASMODIUM FALCIPARUM
恶性疟原虫 DNA 碱基切除修复
- 批准号:
6632428 - 财政年份:2001
- 资助金额:
$ 40万 - 项目类别:
DNA BASE EXCISION REPAIR IN PLASMODIUM FALCIPARUM
恶性疟原虫 DNA 碱基切除修复
- 批准号:
6371036 - 财政年份:2001
- 资助金额:
$ 40万 - 项目类别:
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