Admin-Core-001

管理核心-001

• 批准号: 10220175
• 负责人: MARTIN R SCHILLER
• 金额: $ 37.08万
• 依托单位: UNIVERSITY OF NEVADA LAS VEGAS
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10220175
• 关键词: Accreditation; Advisory Committees; Algorithms; Applications Grants; Area; Award; Benchmarking; Big Data; Bioinformatics; Cell Nucleus; Centers of Research Excellence; Collaborations; Consult; Consultations; Contracts; Data; Data Analyses; Development; Diagnostic; Doctor of Philosophy; Education; Ensure; Environment; Faculty; Foundations; Funding; Gene Expression Regulation; Genetic; Genetic Markers; Genetic Research; Genetic Services; Genomics; Goals; Grant; Grant Review; Graph; Human Genetics; Human Genome; Informatics; Infrastructure; Institutes; Laboratory Research; Leadership; Measures; Medical Genetics; Mentors; Monitor; Nevada; Participant; Performance; Phagocytosis; Phase; Preparation; Price; Process; Reporting; Research; Research Infrastructure; Research Personnel; Research Project Grants; Role; Running; Sampling; Schizophrenia; Scientist; Seeds; Services; Structure; United States National Institutes of Health; Work; base; career development; data quality; diagnostic biomarker; epigenetic marker; experience; functional genomics; genome analysis; genome sequencing; genomic data; health care service organization; improved; innovation; medical schools; member; novel; peer; personalized medicine; prodromal Alzheimer' s disease; prognostic; programs; psychosocial; recruit; role model; skills; smoking addiction; testing services

ABSTRACT: ADMINISTRATIVE CORE The Personalized Medicine in Nevada COBRE's long-term goal is to establish itself as a nucleus to enhance human genetics research, as well ss the discovery and application of genetic and epigenetic markers. The proposed COBRE builds upon existing strengths, seed funding from the Nevada Governor's office, and collaboration with the newly accredited UNLV School of Medicine. During the COBRE phase I, we will establish a research program in human genetics and informatics. The major goals are to (Aim 1) administer the program, monitor progress, and iteratively improve the COBRE program; (Aim 2) mentor new investigators to become independent; (Aim 3) expand the human genetics infrastructure at UNLV, in Nevada, and in the IDeA Network; and (Aim 4) cultivate a pipeline of new independent investigators for personalized medicine research. The new investigators and pilot grant awardees will be supported by two research cores centered on genomics and bioinformatics, and a mentoring plan based upon best practices and preliminary studies. The new Genome Analysis and Sequencing Pipeline (GASP) and the Human Genome Data Algorithms to Analytics (HuGe DAtA) Cores, leverage UNLV and local infrastructure The Administrative Core (AC) will be run by PI, Martin Schiller and Co-PI, Xiangning Chen. The external and internal advisory committees, along with consultants will help guide them on COBRE program decisions. The AC will have an oversight role over two research cores, three new investigator research projects, a pilot grant program, and a mentoring panel. The main responsibilities for the Administrative Core are: providing leadership, governance of the COBRE, fiscal management, promoting interactions among institute participants and with external organizations, assessing performance, reporting to NIH, program oversight, and organization of mentoring activities. The AC will work with an independent Program Assessor to monitor progress toward key milestones and benchmarks for the program, and use this information in consultation with the external advisory boards for cycles of improvement each year. Some of the innovative aspects of this proposal are: (1) the COBRE research theme on discovery and application of genetic and epigenetic markers for personalize medicine; (2) having new investigators review grants for Grant Club and the CTR-IN Advance to Funding program; (3) the GASP Core supporting the use and ensure quality of other core services; and (4) a novel assessment approach using graph analytics as a surrogate for measuring culture.

摘要：管理核心 内华达州柯布尔（Nevada Cobre）的长期目标的个性化医学是将自己确立为一种核心，以增强 人类遗传学研究以及遗传和表观遗传标记的发现和应用。这 拟议的毛线基于现有优势，内华达州州长办公室的种子资金以及 与新认可的UNLV医学院合作。在第一阶段，我们将建立 人类遗传学和信息学研究计划。主要目标是（AIM 1）管理该计划， 监视进度，并迭代改善毛毛额计划； （目标2）指导新调查人员成为 独立的; （AIM 3）在UNLV，内华达州和Idea网络中扩展人类遗传基础设施； （AIM 4）培养新的独立研究人员进行个性化医学研究的管道。新的 调查人员和飞行员赠款获奖者将得到两个以基因组学为中心的研究核心和 生物信息学，以及基于最佳实践和初步研究的指导计划。新基因组 分析和测序管道（GASP）和人类基因组数据算法分析（大数据） 核心，利用UNLV和本地基础设施 行政核心（AC）将由Pi，Martin Schiller和Co-Pi（Xiangning Chen）运行。外部和 内部咨询委员会以及顾问将帮助他们指导他们做出毛bre计划的决策。这 AC将在两个研究核心，三个新的研究人员研究项目，试点赠款的两个研究核心上扮演监督角色 程序和指导小组。行政核心的主要职责是：提供 领导力，毛病的治理，财政管理，促进研究所参与者之间的互动 以及外部组织，评估绩效，向NIH报告，计划监督和组织 指导活动。 AC将与独立计划评估员合作，以监控进度 该计划的关键里程碑和基准，并与外部协商使用此信息 每年改进周期的咨询委员会。该提案的一些创新方面是：（1） 关于遗传和表观遗传标记的山核桃研究主题 药品; （2）让新调查人员审查赠款俱乐部的赠款，并提前获得资金 程序; （3）支持使用并确保其他核心服务质量的GASP核心； （4）小说 使用图分析作为测量培养物的替代物的评估方法。