Personalized Medicine in Nevada COBRE

摘要：总体 社会正在超越“试错医学”，进入一个新的数据驱动的时代， 化妆用于提高医疗诊断、预后和治疗的准确性[1，2]。在巴拉克·奥巴马总统 奥巴马在2015年1月20日的国情咨文中，他提到了承诺，以及未来的投资 个性化医疗。包括美国国立卫生研究院（NIH）院长弗朗西斯柯林斯在内的许多专家， 医学博士认为，现在所谓的个性化、精确化或个体化医学将改变未来 医疗保健。随着新兴的遗传技术逐渐成为一些临床中的护理标准， 在学术医疗中心的推动下，它们将继续得到改善。现代基因组和 相关的生物信息学分析已经成为现代生物医学研究的主要内容。但没有 COBRE在个性化医疗中的作用，尽管它的影响力越来越大。NIH COBRE计划旨在加强 生物医学研究基础设施和提高竞争力的研究机构发展奖 （IDEA）合格的州。现代基因组学和生物信息学分析已经成为现代生物技术的主要内容。 生物医学研究然而，尽管COBRE的影响力越来越大，但在个性化医疗中并不存在COBRE。 UNLV具有独特的优势来满足这一迫切的未满足的需求。眼镜蛇的科学前提是 通过前沿研究，推进基因组学和遗传学在个性化医疗中的应用 发现和使用遗传标记，建立一个卓越的中心，培养新的研究人员 独立，并与UNLV医学院和其他合作伙伴在基础和 翻译研究与NIH COBRE计划的目标一致， 研究基础设施和竞争性研究在IDEA合格的国家，我们提出了三个目标：（1）建立一个 持续的个性化医疗中心;（2）培养新的研究者成长和独立性;（3） 发展个性化医疗研究为了实现这些目标，我们提出的COBRE由一个 管理核心（AC），新的人类基因组数据分析算法（HuGe DAtA）核心和基因组 分析和测序管道（GASP）核心，三个新的研究者研究项目（RP），一个指导 内部和外部专家小组、内部和外部咨询委员会以及试点赠款计划 12个奖项旨在培养新的调查人员。领导和指导团队有 目前的研究集中在个性化医疗主题，稳定的NIH研究经费，以及强大的 指导历史。 这个COBRE将建立一个基础，推出医学遗传学临床服务和未来 通过与UNLV医学院的合作，开展临床遗传学教育计划， 通过护理学院的遗传咨询合作教育项目。类似的结果 都被之前的COBRE计划所利用。COBRE的主要交付成果是RP推进 个性化医疗，新的独立研究人员，新的生物医学研究基础设施，以及新的 个性化医疗方案。可持续性模式建立在预期的第二阶段供资基础上， 资助计划，并研究核心可持续发展的混合模式。

ABSTRACT: OVERALL Society is progressing beyond “trial-and-error medicine” into a new data-driven era wherein one's genetic makeup is used to improve accuracy in medical diagnosis, prognosis, and treatment [1,2]. In President Barack Obama's State of the Union Address on January 20, 2015, he mentioned the promise of, and future investment in, personalized medicine. Many experts, including National Institutes of Health (NIH) Director Francis Collins, MD, believe that what is now called personalized, precision, or individualized medicine will transform the future of healthcare. As emerging genetic technologies gradually become the standard of care in some clinical settings, they will continue to improve, driven largely by academic medical centers. Modern genomic and associated bioinformatic analyses have become a staple of modern biomedical research. However, there is no COBRE in personalized medicine, despite its growing influence. The NIH COBRE program aims to strengthen the biomedical research infrastructure and improve competitive research in Institutional Development Award (IDeA)–eligible states. Modern genomic and bioinformatic analyses have become a staple of modern biomedical research. However, no COBRE exists in personalized medicine, despite its growing influence. UNLV is uniquely positioned to deliver on this urgent unmet need. The scientific premise of our COBRE is to advance the use of genomics and genetics in personalized medicine through cutting-edge research discovery and use of genetic markers, building a center of excellence that fosters new investigator independence, and collaborating with the UNLV School of Medicine and other partners in basic and translational research. Consistent with the goal of the NIH COBRE program i to strengthen biomedical research infrastructure and competitive research in IDeA eligible states, we propose three aims: (1) to build a sustained center in personalized medicine; (2) to nurture new investigator growth and independence; and (3) to grow personalized medicine research. To accomplish these goals our proposed COBRE consists of an Administrative core (AC), new Human Genome Data Algorithms to Analytics (HuGe DAtA) core and Genome Analysis and Sequencing Pipeline (GASP) cores, three new investigator research projects (RPs), a mentoring panel of internal and external experts, internal and external advisory committees, and a pilot grant program with 12 awards intended to cultivate a pipeline of new investigators. The leadership and mentoring teams have current research focused on the personalized medicine theme, steady NIH research funding, and a strong mentoring history. This COBRE will establish a foundation to launch medical genetics clinical services and a future educational program in clinical genetics through its collaboration with the UNLV School of Medicine, and through a collaborative educational program in genetic counseling in the School of Nursing. Similar outcomes were leveraged by previous COBRE programs. The major deliverables of the COBRE are RPs advancing personalized medicine, new independent investigators, a new biomedical research infrastructure, and a new program in personalized medicine. The sustainability model is built upon anticipated phase II funding, a pilot grant program, and research core sustainability hybrid models.