Administrative core

摘要：行政核心 内华达州的个性化医学科布雷的长期目标是建立自己的核心，以增强 人类遗传学研究，以及S对遗传学和表观遗传学的发现和应用。这个 提议的科布雷建立在现有优势的基础上，来自内华达州州长办公室的种子资金，以及 与新获得认证的联合国志愿人员组织医学院合作。在科布雷第一阶段，我们将建立 人类遗传学和信息学的研究项目。主要目标是(目标1)管理该计划， 监控进度，反复改进Cobre计划；(目标2)指导新的调查人员成为 独立；(目标3)扩大联合国志愿人员组织、内华达州大学和IDEA网络的人类遗传学基础设施； 以及(目标4)为个性化医学研究培养一批新的独立调查人员。新的 研究人员和试点获奖者将得到两个以基因组学和 生物信息学，以及基于最佳做法和初步研究的指导计划。新的基因组 分析和测序管道(GAP)和人类基因组数据算法到分析(大数据) 核心，利用UNLV和当地基础设施 行政核心(AC)将由Pi，Martin Schiller和Co-Pi，Chen香宁负责。外部和 内部咨询委员会以及顾问将帮助他们在Cobre项目决策方面提供指导。这个 AC将对两个研究核心、三个新的调查者研究项目、一项试点拨款进行监督 计划，以及一个指导小组。行政核心的主要职责是：提供 领导力、科布雷的治理、财政管理、促进研究所参与者之间的互动 与外部组织合作，评估绩效，向NIH报告，项目监督和组织 指导活动。咨询委员会将与一名独立的计划评估员合作，监测进展情况 计划的关键里程碑和基准，并在与外部 咨询委员会每年的改进周期。这项建议的一些创新之处包括：(1) 科布雷研究主题：个性化遗传和表观遗传标记的发现和应用 医学；(2)让新的调查人员审查赠款俱乐部和CTR的赠款-提前获得资金 计划；(3)支持使用和确保其他核心服务质量的GAP核心；和(4)新的 使用图形分析作为衡量文化的替代方法的评估方法。

ABSTRACT: ADMINISTRATIVE CORE The Personalized Medicine in Nevada COBRE's long-term goal is to establish itself as a nucleus to enhance human genetics research, as well s the discovery and application of genetic and epigenetic amrkers. The proposed COBRE builds upon existing strengths, seed funding from the Nevada Governor's office, and collaboration with the newly accredited UNLV School of Medicine. During the COBRE phase I, we will establish a research program in human genetics and informatics. The major goals are to (Aim 1) administer the program, monitor progress, and iteratively improve the COBRE program; (Aim 2) mentor new investigators to become independent; (Aim 3) expand the human genetics infrastructure at UNLV, in Nevada, and in the IDeA Network; and (Aim 4) cultivate a pipeline of new independent investigators for personalized medicine research. The new investigators and pilot grant awardees will be supported by two research cores centered on genomics and bioinformatics, and a mentoring plan based upon best practices and preliminary studies. The new Genome Analysis and Sequencing Pipeline (GASP) and the Human Genome Data Algorithms to Analytics (HuGe DAtA) Cores, leverage UNLV and local infrastructure The Administrative Core (AC) will be run by PI, Martin Schiller and Co-PI, Xiangning Chen. The external and internal advisory committees, along with consultants will help guide them on COBRE program decisions. The AC will have an oversight role over two research cores, three new investigator research projects, a pilot grant program, and a mentoring panel. The main responsibilities for the Administrative Core are: providing leadership, governance of the COBRE, fiscal management, promoting interactions among institute participants and with external organizations, assessing performance, reporting to NIH, program oversight, and organization of mentoring activities. The AC will work with an independent Program Assessor to monitor progress toward key milestones and benchmarks for the program, and use this information in consultation with the external advisory boards for cycles of improvement each year. Some of the innovative aspects of this proposal are: (1) the COBRE research theme on discovery and application of genetic and epigenetic markers for personalize medicine; (2) having new investigators review grants for Grant Club and the CTR-IN Advance to Funding program; (3) the GASP Core supporting the use and ensure quality of other core services; and (4) a novel assessment approach using graph analytics as a surrogate for measuring culture.