Co-Abuse Cannabis and Tobacco

共同滥用大麻和烟草

• 批准号: 10219459
• 负责人: JENNY L. WILEY
• 金额: $ 20.4万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10219459
• 关键词: Acute; Address; Adult; Alkaloids; Behavior; Cannabis; Cannabis Abuse; Characteristics; Cigarette; Data; Data Collection; Development; Discipline; Disease; Dose; Drug usage; Education; Electronic cigarette; Epidemiology; Female; Goals; Health; Human; Individual; Inhalation; Laboratory Study; Legal; Literature; Marijuana Dependence; Marijuana Smoking; Measures; Methods; Minor; Modeling; Mus; Nicotine; Outcome; Outpatients; Pattern; Pharmaceutical Preparations; Phase; Placebos; Prevention; Procedures; Psychological reinforcement; Public Health; Relative Risks; Research; Risk; Route; Self Administration; Site; Smoker; Specialist; Sum; Surveys; Tetrahydrocannabinol; Time; Tobacco; Tobacco Use Cessation; Tobacco smoking behavior; Tobacco use; Training; Translational Research; United States; Validation; behavioral pharmacology; craving; epidemiologic data; epidemiology study; hookah; insight; male; marijuana legalization; marijuana use; marijuana use disorder; mouse model; nicotine inhalation; non-smoker; novel; pre-clinical; preventable death; psychosocial; social media; targeted treatment; tobacco products; tobacco smokers; tobacco user; trend

PROJECT SUMMARY Tobacco and cannabis are two of the most commonly abused substances in the United States. Further, simultaneous cannabis and tobacco polysubstance use (CT-PSU) is not insubstantial and is trending upwards as cannabis use is legalized in an increasing number of states. This upward trend is of particular concern because, compared to use of cannabis without tobacco, CT-PSU is associated with greater cannabis dependence, psychosocial problems, and poorer cessation outcomes, as well as with additive health risks, relative to either substance alone. Determination of mechanisms underlying CT-PSU will require coordinated epidemiological, preclinical, and human laboratory studies. Yet, the models and measures in each discipline that are used most often to examine CT-PSU were developed to investigate single drug use and may not capture unique features of CT-PSU. In the proposed project, patterns of CT-PSU will be characterized through development and implementation of novel survey measures that focus specifically on CT-PSU (R21 phase). In addition, a procedure for inhaled nicotine self-administration in mice will be established and validated simultaneously with epidemiological data collection. Subsequently, results from both efforts will guide decisions regarding experimental parameters to be used to investigate the effects of Δ9-tetrahydrocannabinol (THC; primary psychoactive substituent of cannabis) on inhaled nicotine’s reinforcing effects (i.e., “chasing”) and the reinforcing effects of both drugs administered simultaneously (e.g., as in blunts or spliffs) in mice and in human tobacco smokers and non-smokers. This translationally relevant approach will result in the establishment of better models through which to investigate CT-PSU, with the ultimate goals of discovery of its underlying mechanisms and development of targeted treatment approaches.

项目概要 烟草和大麻是美国最常滥用的两种物质。更远， 大麻和烟草多物质同时使用（CT-PSU）并非微不足道，而且呈上升趋势 随着大麻的使用在越来越多的国家合法化。这种上升趋势尤其值得关注 因为，与在没有烟草的情况下使用大麻相比，CT-PSU 与更多的大麻相关 依赖性、社会心理问题和较差的戒烟结果，以及额外的健康风险， 相对于单独的任何一种物质。确定 CT-PSU 背后的机制需要协调一致 流行病学、临床前和人体实验室研究。然而，每个学科的模型和措施 最常用于检查 CT-PSU 的技术是为了调查单一药物的使用而开发的，可能不会 捕捉 CT-PSU 的独特功能。在拟议的项目中，CT-PSU 的模式将通过 制定和实施专门针对 CT-PSU（R21 阶段）的新调查措施。在 此外，将建立并验证小鼠吸入尼古丁自我给药的程序 与流行病学数据收集同时进行。随后，两项努力的结果将指导决策 关于用于研究 Δ9-四氢大麻酚（THC； 大麻的主要精神活性替代品）对吸入尼古丁的增强作用（即“追逐”）和 同时施用两种药物（例如钝器或spliffs）对小鼠和人类的增强作用 吸烟者和不吸烟者。这种与翻译相关的方法将导致建立 通过更好的模型来研究 CT-PSU，最终目标是发现其底层 机制和有针对性的治疗方法的发展。