Behavioral Pharmacology of Synthetic Cannabinoids
合成大麻素的行为药理学
基本信息
- 批准号:8269961
- 负责人:
- 金额:$ 9.88万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-07-01 至 2013-06-30
- 项目状态:已结题
- 来源:
- 关键词:AcuteAdvertisingAffinityAppearanceBehavioralBehavioral AssayCNR1 geneCannabinoidsCannabisDependenceDrug ToleranceDrug abuseEvaluationFemaleFutureGoalsGoldGrantHealthHousingIndolesInternetIntoxicationKnowledgeLegalMarijuanaMarketingMotorMusNaturePharmacologyPhysical DependencePlantsProceduresProcessPropertyReportingResearchResearch PersonnelRodentRodent ModelSamplingSeriesSex CharacteristicsSmokeSmokingSourceSpicesStructureStructure-Activity RelationshipSubstance abuse problemTestingTetrahydrocannabinolTimeUniversitiesbasebehavioral pharmacologycannabinoid receptordrug abuserdrug discriminationfluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl etherfollow-upin vivoin vivo Modelmalepre-clinicalresearch studysextool
项目摘要
DESCRIPTION (provided by applicant): Smoking of cannabinoid-enhanced "spices" is an emerging substance abuse problem. Although JWH-018 and other indole-derived cannabinoids that have been identified in Spice products produce marijuana-like intoxication, they are structurally distinct from cannabinoids contained in the cannabis plant; hence, in many states, they are not currently illegal and are readily available over the internet and in headshops. Indole-derived cannabinoids were originally developed as research tools to investigate the nature of cannabinoid receptors; however, very little is known about their pharmacology, particularly their behavioral effects, as only a small sample of the over 200 compounds in the JWH series have been tested in preclinical in vivo models. The proposed research will synthesize and evaluate JWH-018 and related indole-derived cannabinoids in rodent models that have been used to investigate the abuse properties of cannabinoids. Emphasis will be placed on determination of the extent to which the in vivo pharmacological profile of this class of cannabinoids differs from that of ?9-tetrahydrocannabinol, the primary psychoactive substituent of the marijuana plant. Further, use of male and female rodents will allow examination of possible sex differences in the effects of these cannabinoids. Results of the studies proposed here will increase knowledge of the behavioral effects of these abused cannabinoids in both sexes, thereby providing a scientific basis for evaluation of potential health concerns associated with acute and repeated use of the compounds, including their physical dependence liability.
描述(由申请人提供):吸食大麻素增强的“香料”是一种新出现的药物滥用问题。虽然JWH-018和其他在Spice产品中发现的吲哚衍生大麻素会产生大麻样中毒,但它们在结构上与大麻植物中含有的大麻素不同;因此,在许多州,它们目前并不违法,并且可以通过互联网和总店轻松获得。吲哚衍生的大麻素最初是作为研究大麻素受体性质的研究工具开发的;然而,对它们的药理学,特别是它们的行为效应知之甚少,因为JWH系列中的200多种化合物中只有一小部分在临床前体内模型中进行了测试。拟议的研究将在啮齿动物模型中合成和评估JWH-018和相关的吲哚衍生大麻素,这些模型已用于研究大麻素的滥用特性。重点将放在确定在何种程度上,这类大麻素的体内药理学概况不同于?9-四氢大麻酚,大麻植物的主要精神活性取代物。此外,使用雄性和雌性啮齿动物将允许检查这些大麻素的影响中可能的性别差异。本文提出的研究结果将增加对这些滥用大麻素在两性中的行为影响的了解,从而为评估与急性和重复使用这些化合物相关的潜在健康问题提供科学依据,包括其身体依赖性。
项目成果
期刊论文数量(9)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Analysis of synthetic cannabinoids using high-resolution mass spectrometry and mass defect filtering: implications for nontargeted screening of designer drugs.
使用高分辨率的质谱和质谱滤波来分析合成大麻素,对设计师药物的非目标筛查的影响。
- DOI:10.1021/ac300509h
- 发表时间:2012-07-03
- 期刊:
- 影响因子:7.4
- 作者:Grabenauer M;Krol WL;Wiley JL;Thomas BF
- 通讯作者:Thomas BF
Hijacking of Basic Research: The Case of Synthetic Cannabinoids.
基础研究的劫持:合成大麻素的案例。
- DOI:10.3768/rtipress.2011.op.0007.1111
- 发表时间:2011
- 期刊:
- 影响因子:0
- 作者:Wiley,JennyL;Marusich,JulieA;Huffman,JohnW;Balster,RobertL;Thomas,BrianF
- 通讯作者:Thomas,BrianF
Moving around the molecule: relationship between chemical structure and in vivo activity of synthetic cannabinoids.
- DOI:10.1016/j.lfs.2013.09.011
- 发表时间:2014-02-27
- 期刊:
- 影响因子:6.1
- 作者:Wiley, Jenny L.;Marusich, Julie A.;Huffman, John W.
- 通讯作者:Huffman, John W.
Synthesis and pharmacology of 1-alkyl-3-(1-naphthoyl)indoles: steric and electronic effects of 4- and 8-halogenated naphthoyl substituents.
1-烷基-3-(1-萘甲酰基)吲哚的合成和药理学:4-和8-卤代萘甲酰基取代基的空间和电子效应。
- DOI:10.1016/j.bmc.2012.01.038
- 发表时间:2012
- 期刊:
- 影响因子:3.5
- 作者:Wiley,JennyL;Smith,ValerieJ;Chen,Jianhong;Martin,BillyR;Huffman,JohnW
- 通讯作者:Huffman,JohnW
Cross-substitution of Δ9-tetrahydrocannabinol and JWH-018 in drug discrimination in rats.
α9-四氢大麻酚和 JWH-018 在大鼠药物辨别中的交叉替代。
- DOI:10.1016/j.pbb.2014.05.016
- 发表时间:2014
- 期刊:
- 影响因子:0
- 作者:Wiley,JennyL;Lefever,TimothyW;Cortes,RicardoA;Marusich,JulieA
- 通讯作者:Marusich,JulieA
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
JENNY L. WILEY其他文献
JENNY L. WILEY的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('JENNY L. WILEY', 18)}}的其他基金
Minor Cannabinoids and Terpenes: Preclinical Evaluation as Analgesics
次要大麻素和萜烯:作为镇痛药的临床前评估
- 批准号:
9895190 - 财政年份:2019
- 资助金额:
$ 9.88万 - 项目类别:
Minor Cannabinoids and Terpenes: Preclinical Evaluation as Analgesics
次要大麻素和萜烯:作为镇痛药的临床前评估
- 批准号:
10015203 - 财政年份:2019
- 资助金额:
$ 9.88万 - 项目类别:
Investigation of Synthetic Cannabinoid Exposures and Pharmacological Consequences
合成大麻素暴露和药理学后果的调查
- 批准号:
9899222 - 财政年份:2016
- 资助金额:
$ 9.88万 - 项目类别:
相似国自然基金
小型类人猿合唱节奏的功能假说——宣
示社会关系(Social bond
advertising) ——验证研究
- 批准号:
- 批准年份:2025
- 资助金额:10.0 万元
- 项目类别:省市级项目
相似海外基金
SaTC: CORE: Medium: Increasing user autonomy and advertiser and platform responsibility in online advertising
SaTC:核心:中:增加在线广告中的用户自主权以及广告商和平台责任
- 批准号:
2318290 - 财政年份:2024
- 资助金额:
$ 9.88万 - 项目类别:
Continuing Grant
Marketing meaninglessness: critical anthropology of transnational advertising agencies
营销无意义:跨国广告公司的批判人类学
- 批准号:
2724869 - 财政年份:2024
- 资助金额:
$ 9.88万 - 项目类别:
Studentship
Innovation in Manufacturing to benefit the Marketing & Advertising Industry
制造创新有利于营销
- 批准号:
10064566 - 财政年份:2023
- 资助金额:
$ 9.88万 - 项目类别:
Collaborative R&D
Collaborative Research: SaTC: CORE: Medium: Understanding and Combatting Impersonation Attacks and Data Leakage in Online Advertising
协作研究:SaTC:核心:媒介:理解和打击在线广告中的冒充攻击和数据泄露
- 批准号:
2247516 - 财政年份:2023
- 资助金额:
$ 9.88万 - 项目类别:
Continuing Grant
A Dynamic Analysis of Advertising Interactive Techniques to Gain the Consumer Engagement
获得消费者参与的广告互动技术的动态分析
- 批准号:
23K01642 - 财政年份:2023
- 资助金额:
$ 9.88万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The Impact of Programmatic Advertising on Market Competition
程序化广告对市场竞争的影响
- 批准号:
23K18786 - 财政年份:2023
- 资助金额:
$ 9.88万 - 项目类别:
Grant-in-Aid for Research Activity Start-up
Enabling profitable digital advertising for British SMEs with AI-powered multichannel ads brokerage service
通过人工智能驱动的多渠道广告经纪服务,为英国中小企业实现盈利的数字广告
- 批准号:
10070962 - 财政年份:2023
- 资助金额:
$ 9.88万 - 项目类别:
Collaborative R&D
Cross-Platform Advertising Accountability
跨平台广告责任
- 批准号:
10071299 - 财政年份:2023
- 资助金额:
$ 9.88万 - 项目类别:
Collaborative R&D
Improving the accountability of dark advertising on digital platforms
提高数字平台上暗广告的问责制
- 批准号:
IE230100647 - 财政年份:2023
- 资助金额:
$ 9.88万 - 项目类别:
Early Career Industry Fellowships
The frequency and distribution of alcohol advertising on broadcast television in Canada and its potential implications for youth and public health policy
加拿大广播电视上酒类广告的频率和分布及其对青年和公共卫生政策的潜在影响
- 批准号:
493189 - 财政年份:2023
- 资助金额:
$ 9.88万 - 项目类别: