The mediating role of Slow Wave Sleep and Vascular Risk Factors on Alzheimer Disease related disparity between African-Americans and non-Hispanic Whites

项目摘要/摘要： K23的重新提交是为纽约大学医学院(NYUSoM)助理教授Bubu博士在 他独特的背景使他成为这一研究领域的理想人选。Bubu博士在神经学、神经流行病学和公共卫生方面接受过研究生、实习和研究员级别的临床和研究培训。他毕业于纽约大学国立卫生研究院资助的旨在提供一致导师以实现神经科学研究学术多样性的项目(1R25NS094093-01)，最近在T32资助机制下成为纽约大学人口健康系的博士后研究员(T32HL129953)。他最近获得了NIA资助的哥伦比亚阿尔茨海默病差异试验跨学科研究中心(CIRAD；P30 AG059303)拨款，用于开展阻塞性睡眠呼吸暂停(OSA)和种族对血浆tau和神经丝光蛋白相互作用的原创性研究。 职业发展和培训计划：Bubu博士在健康差距研究和MRI/PET数据分析方面的培训计划 将NYUSoM和附近位于纽约曼哈顿地区的世界知名医疗中心的卓越研究和教育环境与全国知名的专家导师结合在一起。他的顾问委员会由Jean-Louis博士(纽约大学健康差距研究的主要导师和专家)、Osorio博士(纽约大学健康脑老化和神经退行性变的共同主要导师和专家)、Ayappa博士(西奈山大学睡眠/OSA生理学联合导师和专家)、Ogedesbe博士(纽约大学心血管疾病差距研究顾问和专家)、De Leon博士(Weill Cornell大学AD神经成像和生物标记物顾问和专家)以及Manly博士(哥伦比亚大学服务不足人群的神经心理学方法顾问和专家)组成。他的培训计划以精心设计的课程作业和实践培训经验为特色。 研究计划：慢波睡眠(SWS)和血管风险与AD风险相关。黑人/非裔美国老年人 与白人相比，成年人受阿尔茨海默病的影响不成比例，SWS持续时间明显缩短，阿尔茨海默病的血管风险因素(VRF)患病率更高。此外，睡眠问题和VRF经常同时发生。更重要的是，找出阿尔茨海默病认知能力下降风险较高的无症状黑人，对于预防黑人阿尔茨海默病的发病至关重要。Bubu博士的研究建议侧重于SWS和VRF在黑人和非西班牙裔白人之间与AD相关的差异方面的调解作用的横向和纵向关系(目标1-3)。这一提议代表了新的、原创的、以假设为导向的工作，具有坚实的理论基础。预计每个目标都将产生出版的手稿和数据，这将直接通知和塑造未来的R01-应用。这一培训和研究计划将使Bubu博士成为一名独立研究员和领导者，研究健康行为，特别是睡眠和VRF对黑人晚年认知功能的影响。

PROJECT SUMMARY/ABSTRACT: This K23 resubmission is for Dr. Bubu, an Assistant Professor at NYU School of Medicine (NYUSoM), in the Departments of Psychiatry and Population Health, who is fully committed to becoming an independently funded investigator studying how age-related and age-dependent sleep changes, and vascular risk, impact cognitive decline and Alzheimer’s disease (AD) risk, and how they drive AD related disparities. His unique background makes him an ideal candidate for this field of research. Dr. Bubu has graduate, internship, and fellowship-level clinical and research training in neurology, neuro-epidemiology and public health. He is a graduate of the NYU’s NIH-funded Program to provide Congruent Mentorship to Reach Academic Diversity in Neuroscience Research (1R25NS094093-01), and was recently supported as a postdoctoral fellow at NYUSoM Department of Population Health under a T32 funding mechanism (T32HL129953). He was recently awarded the NIA funded Columbia Center for Interdisciplinary Research on Alzheimer’s disease Disparities Pilot (CIRAD; P30 AG059303) grant to conduct original research on the interaction of obstructive sleep apnea (OSA) and race on plasma tau, and neurofilament light protein. Career development and training plan: Dr. Bubu’s training plan in health disparities research and MRI/PET data analysis couples an outstanding research and education environment at NYUSoM and nearby world-renowned medical centers in the New York Manhattan area with nationally renowned expert mentors. His advisory committee is comprised of Drs. Jean-Louis (primary mentor and expert in health disparity research at NYU), Osorio (co-primary mentor and expert in healthy brain aging and neurodegeneration, at NYU), Ayappa (co-mentor and expert in sleep/OSA physiology, at Mount Sinai), Ogedegbe (adviser and expert in CVD disparity research at NYU), de Leon (adviser and expert in AD neuroimaging and biomarkers at Weill Cornell), and Manly (consultant and expert in neuropsychological methods in underserved populations at Columbia). His training plan features carefully designed coursework and hands-on training experiences. Research plan: Slow wave sleep (SWS) and vascular risk are associated with AD risk. Black/African-American older adults are disproportionately affected by Alzheimer’s disease, have significantly less SWS duration and higher prevalence of vascular risk factors (VRFs) for Alzheimer’s disease, compared to whites. In addition, sleep problems and VRFs often co-occur. More importantly, identifying asymptomatic blacks at higher risk of cognitive decline from Alzheimer’s disease is crucial to preventing its onset among blacks. Dr. Bubu’s research proposal focuses on both cross-sectional and longitudinal relationships (Aims 1 -3) of the mediating role of SWS and VRFs on AD related disparity between blacks and on-Hispanic whites. This proposal represents new, original, and hypothesis-driven work with a strong theoretical foundation. It is expected that each Aim will result in published manuscripts and data, which will directly inform and shape future R01-applications. This training and research plan will enable Dr. Bubu to become an independent researcher and leader in the impact of health behaviors, specifically sleep and VRFs on late-life cognitive functioning in blacks.