The mediating role of Slow Wave Sleep and Vascular Risk Factors on Alzheimer Disease related disparity between African-Americans and non-Hispanic Whites

慢波睡眠和血管危险因素对非裔美国人和非西班牙裔白人之间阿尔茨海默病相关差异的中介作用

• 批准号: 10215950
• 负责人: OMONIGHO A MICHAEL Bubu
• 金额: $ 19.83万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-15 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10215950
• 关键词: Address; Advisory Committees; Affect; African; African American; Age; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer' s disease risk; Alzheimer’s disease biomarker; Amyloid; Amyloid beta-42; Amyloid beta-Protein; Amyloid deposition; Area; Automobile Driving; Autopsy; Award; Behavior; Biological; Biological Assay; Biological Markers; Blood Vessels; Characteristics; Clinical; Clinical Research; Cognition; Cognitive; Complement; Couples; Data; Data Analyses; Development; Diabetes Mellitus; Diagnostic; Diffusion; Education; Elderly; Electroencephalography; Environment; Excessive Daytime Sleepiness; Fellowship; Foundations; Framingham Heart Study; Funding; Funding Mechanisms; Future; Goals; Grant; Health behavior; High Prevalence; Hispanics; Home; Hypertension; Image; Immunoprecipitation; Impaired cognition; Individual; Interdisciplinary Study; Internships; Intervention; Jackson Heart Study; Lesion; Magnetic Resonance Imaging; Manuscripts; Mass Spectrum Analysis; Measures; Mediating; Medical center; Mentors; Mentorship; Methods; Minority; Nerve Degeneration; Neuroepidemiology; Neurology; Neuropsychology; Neurosciences Research; New York; Not Hispanic or Latino; Obstructive Sleep Apnea; Parents; Participant; Pathologic; Physiological; Physiology; Plasma; Polysomnography; Positron-Emission Tomography; Postdoctoral Fellow; Procedures; Psychiatry; Public Health; Publishing; Quality Control; Race; Recording of previous events; Research; Research Personnel; Research Proposals; Research Training; Risk; Role; Shapes; Sleep; Sleep Disorders; Sleep disturbances; Slow-Wave Sleep; Testing; Training; Underserved Population; United States National Institutes of Health; Work; age related; aging brain; base; cardiovascular risk factor; career development; clinical practice; cognitive change; cognitive function; cohort; comorbidity; data resource; design; disease disparity; experience; health disparity; high risk; improved; in vivo; indexing; innovation; medical schools; minimal risk; molecular marker; multimodality; neurofilament protein L; neuroimaging; neuroimaging marker; new therapeutic target; novel; parent grant; population health; pre-clinical; prevent; professor; programs; prospective; racial difference; ranpirnase; screening; sleep quality; tau Proteins; unethical; uptake; vascular risk factor; white matter; β-amyloid burden

PROJECT SUMMARY/ABSTRACT: This K23 resubmission is for Dr. Bubu, an Assistant Professor at NYU School of Medicine (NYUSoM), in the Departments of Psychiatry and Population Health, who is fully committed to becoming an independently funded investigator studying how age-related and age-dependent sleep changes, and vascular risk, impact cognitive decline and Alzheimer’s disease (AD) risk, and how they drive AD related disparities. His unique background makes him an ideal candidate for this field of research. Dr. Bubu has graduate, internship, and fellowship-level clinical and research training in neurology, neuro-epidemiology and public health. He is a graduate of the NYU’s NIH-funded Program to provide Congruent Mentorship to Reach Academic Diversity in Neuroscience Research (1R25NS094093-01), and was recently supported as a postdoctoral fellow at NYUSoM Department of Population Health under a T32 funding mechanism (T32HL129953). He was recently awarded the NIA funded Columbia Center for Interdisciplinary Research on Alzheimer’s disease Disparities Pilot (CIRAD; P30 AG059303) grant to conduct original research on the interaction of obstructive sleep apnea (OSA) and race on plasma tau, and neurofilament light protein. Career development and training plan: Dr. Bubu’s training plan in health disparities research and MRI/PET data analysis couples an outstanding research and education environment at NYUSoM and nearby world-renowned medical centers in the New York Manhattan area with nationally renowned expert mentors. His advisory committee is comprised of Drs. Jean-Louis (primary mentor and expert in health disparity research at NYU), Osorio (co-primary mentor and expert in healthy brain aging and neurodegeneration, at NYU), Ayappa (co-mentor and expert in sleep/OSA physiology, at Mount Sinai), Ogedegbe (adviser and expert in CVD disparity research at NYU), de Leon (adviser and expert in AD neuroimaging and biomarkers at Weill Cornell), and Manly (consultant and expert in neuropsychological methods in underserved populations at Columbia). His training plan features carefully designed coursework and hands-on training experiences. Research plan: Slow wave sleep (SWS) and vascular risk are associated with AD risk. Black/African-American older adults are disproportionately affected by Alzheimer’s disease, have significantly less SWS duration and higher prevalence of vascular risk factors (VRFs) for Alzheimer’s disease, compared to whites. In addition, sleep problems and VRFs often co-occur. More importantly, identifying asymptomatic blacks at higher risk of cognitive decline from Alzheimer’s disease is crucial to preventing its onset among blacks. Dr. Bubu’s research proposal focuses on both cross-sectional and longitudinal relationships (Aims 1 -3) of the mediating role of SWS and VRFs on AD related disparity between blacks and on-Hispanic whites. This proposal represents new, original, and hypothesis-driven work with a strong theoretical foundation. It is expected that each Aim will result in published manuscripts and data, which will directly inform and shape future R01-applications. This training and research plan will enable Dr. Bubu to become an independent researcher and leader in the impact of health behaviors, specifically sleep and VRFs on late-life cognitive functioning in blacks.

项目总结/摘要： 这个K23重新提交是为纽约大学医学院（NYUSoM）助理教授Bubu博士，在 精神病学和人口健康部门，他完全致力于成为一名独立资助的研究人员，研究年龄相关和年龄依赖性睡眠变化和血管风险如何影响认知能力下降和阿尔茨海默病（AD）风险，以及它们如何驱动AD相关的差异。他独特的背景使他成为这一研究领域的理想人选。Bubu博士在神经病学，神经流行病学和公共卫生领域接受过研究生，实习和研究员级别的临床和研究培训。他毕业于纽约大学NIH资助的项目，为神经科学研究提供一致的导师以实现学术多样性（1 R25 NS 094093 -01），最近在T32资助机制下（T32 HL 129953）获得了纽约大学人口健康系博士后研究员的支持。他最近获得了NIA资助的哥伦比亚阿尔茨海默病差异试点跨学科研究中心（CIRAD; P30 AG 059303）资助，以进行阻塞性睡眠呼吸暂停（OSA）和种族对血浆tau蛋白和神经丝轻蛋白相互作用的原创性研究。 职业发展和培训计划：Bubu博士的健康差异研究和MRI/PET数据分析培训计划 将NYUSoM和附近纽约曼哈顿地区世界知名的医疗中心的优秀研究和教育环境与全国知名的专家导师结合起来。他的顾问委员会由让-路易博士（纽约大学健康差异研究的主要导师和专家），Osorio（纽约大学健康大脑老化和神经退行性疾病的共同主要导师和专家），Ayappa（西奈山睡眠/OSA生理学共同导师和专家），Ogedegbe（纽约大学心血管疾病差异研究顾问和专家），德莱昂（Weill Cornell的AD神经影像学和生物标志物顾问和专家）和Manly（哥伦比亚的服务不足人群的神经心理学方法顾问和专家）。他的培训计划包括精心设计的课程和实践培训经验。 研究计划：慢波睡眠（SWS）和血管风险与AD风险相关。黑人/非裔美国老年人 与白人相比，成年人受阿尔茨海默病的影响不成比例，SWS持续时间显著缩短，阿尔茨海默病的血管危险因素（VRF）患病率较高。此外，睡眠问题和VRF经常同时发生。更重要的是，确定无症状的黑人在阿尔茨海默病认知能力下降的风险较高，是至关重要的，以防止其在黑人中的发病。Bubu博士的研究建议侧重于SWS和VRF对黑人和非西班牙裔白人之间AD相关差异的介导作用的横截面和纵向关系（目标1 - 3）。该提案代表了具有强大理论基础的新的、原创的、假设驱动的工作。预计每个Aim都将产生出版的手稿和数据，这些将直接影响和塑造未来的R 01应用。这项培训和研究计划将使Bubu博士成为健康行为影响的独立研究人员和领导者，特别是睡眠和VRF对黑人晚年认知功能的影响。