The mediating role of Slow Wave Sleep and Vascular Risk Factors on Alzheimer Disease related disparity between African-Americans and non-Hispanic Whites

慢波睡眠和血管危险因素对非裔美国人和非西班牙裔白人之间阿尔茨海默病相关差异的中介作用

• 批准号: 10215950
• 负责人: OMONIGHO A MICHAEL Bubu
• 金额: $ 19.83万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-15 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10215950
• 关键词: Address; Advisory Committees; Affect; African; African American; Age; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer' s disease risk; Alzheimer’s disease biomarker; Amyloid; Amyloid beta-42; Amyloid beta-Protein; Amyloid deposition; Area; Automobile Driving; Autopsy; Award; Behavior; Biological; Biological Assay; Biological Markers; Blood Vessels; Characteristics; Clinical; Clinical Research; Cognition; Cognitive; Complement; Couples; Data; Data Analyses; Development; Diabetes Mellitus; Diagnostic; Diffusion; Education; Elderly; Electroencephalography; Environment; Excessive Daytime Sleepiness; Fellowship; Foundations; Framingham Heart Study; Funding; Funding Mechanisms; Future; Goals; Grant; Health behavior; High Prevalence; Hispanics; Home; Hypertension; Image; Immunoprecipitation; Impaired cognition; Individual; Interdisciplinary Study; Internships; Intervention; Jackson Heart Study; Lesion; Magnetic Resonance Imaging; Manuscripts; Mass Spectrum Analysis; Measures; Mediating; Medical center; Mentors; Mentorship; Methods; Minority; Nerve Degeneration; Neuroepidemiology; Neurology; Neuropsychology; Neurosciences Research; New York; Not Hispanic or Latino; Obstructive Sleep Apnea; Parents; Participant; Pathologic; Physiological; Physiology; Plasma; Polysomnography; Positron-Emission Tomography; Postdoctoral Fellow; Procedures; Psychiatry; Public Health; Publishing; Quality Control; Race; Recording of previous events; Research; Research Personnel; Research Proposals; Research Training; Risk; Role; Shapes; Sleep; Sleep Disorders; Sleep disturbances; Slow-Wave Sleep; Testing; Training; Underserved Population; United States National Institutes of Health; Work; age related; aging brain; base; cardiovascular risk factor; career development; clinical practice; cognitive change; cognitive function; cohort; comorbidity; data resource; design; disease disparity; experience; health disparity; high risk; improved; in vivo; indexing; innovation; medical schools; minimal risk; molecular marker; multimodality; neurofilament protein L; neuroimaging; neuroimaging marker; new therapeutic target; novel; parent grant; population health; pre-clinical; prevent; professor; programs; prospective; racial difference; ranpirnase; screening; sleep quality; tau Proteins; unethical; uptake; vascular risk factor; white matter; β-amyloid burden

PROJECT SUMMARY/ABSTRACT: This K23 resubmission is for Dr. Bubu, an Assistant Professor at NYU School of Medicine (NYUSoM), in the Departments of Psychiatry and Population Health, who is fully committed to becoming an independently funded investigator studying how age-related and age-dependent sleep changes, and vascular risk, impact cognitive decline and Alzheimer’s disease (AD) risk, and how they drive AD related disparities. His unique background makes him an ideal candidate for this field of research. Dr. Bubu has graduate, internship, and fellowship-level clinical and research training in neurology, neuro-epidemiology and public health. He is a graduate of the NYU’s NIH-funded Program to provide Congruent Mentorship to Reach Academic Diversity in Neuroscience Research (1R25NS094093-01), and was recently supported as a postdoctoral fellow at NYUSoM Department of Population Health under a T32 funding mechanism (T32HL129953). He was recently awarded the NIA funded Columbia Center for Interdisciplinary Research on Alzheimer’s disease Disparities Pilot (CIRAD; P30 AG059303) grant to conduct original research on the interaction of obstructive sleep apnea (OSA) and race on plasma tau, and neurofilament light protein. Career development and training plan: Dr. Bubu’s training plan in health disparities research and MRI/PET data analysis couples an outstanding research and education environment at NYUSoM and nearby world-renowned medical centers in the New York Manhattan area with nationally renowned expert mentors. His advisory committee is comprised of Drs. Jean-Louis (primary mentor and expert in health disparity research at NYU), Osorio (co-primary mentor and expert in healthy brain aging and neurodegeneration, at NYU), Ayappa (co-mentor and expert in sleep/OSA physiology, at Mount Sinai), Ogedegbe (adviser and expert in CVD disparity research at NYU), de Leon (adviser and expert in AD neuroimaging and biomarkers at Weill Cornell), and Manly (consultant and expert in neuropsychological methods in underserved populations at Columbia). His training plan features carefully designed coursework and hands-on training experiences. Research plan: Slow wave sleep (SWS) and vascular risk are associated with AD risk. Black/African-American older adults are disproportionately affected by Alzheimer’s disease, have significantly less SWS duration and higher prevalence of vascular risk factors (VRFs) for Alzheimer’s disease, compared to whites. In addition, sleep problems and VRFs often co-occur. More importantly, identifying asymptomatic blacks at higher risk of cognitive decline from Alzheimer’s disease is crucial to preventing its onset among blacks. Dr. Bubu’s research proposal focuses on both cross-sectional and longitudinal relationships (Aims 1 -3) of the mediating role of SWS and VRFs on AD related disparity between blacks and on-Hispanic whites. This proposal represents new, original, and hypothesis-driven work with a strong theoretical foundation. It is expected that each Aim will result in published manuscripts and data, which will directly inform and shape future R01-applications. This training and research plan will enable Dr. Bubu to become an independent researcher and leader in the impact of health behaviors, specifically sleep and VRFs on late-life cognitive functioning in blacks.

项目摘要/摘要： 此K23重新提交是针对纽约大学医学院（NYUSOM）助理教授Bubu博士的 精神病学和人口健康部门完全致力于成为一名独立资助的研究人员，研究与年龄相关和年龄依赖年龄的睡眠变化以及血管风险，影响认知能力下降和阿尔茨海默氏病（AD）风险以及如何推动与AD相关的分布。他独特的背景使他成为这一研究领域的理想候选人。 Bubu博士已毕业，实习和奖学金水平的临床和研究培训，他是NYU NIH资助的计划的毕业生，旨在提供一致的指导，以达到神经科学研究的学术多样性（1R25NS094093-01），最近在Nyusol Suffent of Nector机构中得到了支持， （T32HL129953）。最近，他被授予NIA资助的哥伦比亚跨学科研究中心关于阿尔茨海默氏病差异差异飞行员（CIRAD； P30 AG059303）赠款，以进行有关阻塞性睡眠呼吸暂停（OSA）（OSA）和种族在Plasma Tau上的相互作用的原始研究，并进行了plasma tau和Neurofilament Light Light Protin。 职业发展和培训计划：BUBU博士在健康分配研究和MRI/PET数据分析方面的培训计划 在纽约市和纽约曼哈顿地区近乎世界著名的医疗中心与全国知名的专家导师一起，融合了一个杰出的研究和教育环境。他的咨询委员会由Drs组成。 Jean-Louis (primary mentor and expert in health disparity research at NYU), Osorio (co-primary mentor and expert in healthy brain aging and neurodegeneration, at NYU), Ayappa (co-mentor and expert in sleep/OSA physiology, at Mount Sinai), Ogedegbe (adviser and expert in CVD disparity research at NYU), de Leon (adviser and expert in AD neuroimaging and威尔·康奈尔（Weill Cornell）的生物标志物）和男子气概（哥伦比亚服务不足人群的神经心理学方法的顾问和专家）。他的培训计划以精心设计的课程和动手培训经验为特色。 研究计划：慢波睡眠（SWS）和血管风险与AD风险有关。黑人/非裔美国人年龄较大 与白人相比，成年人受阿尔茨海默氏病的影响不成比例地受到阿尔茨海默氏病的影响，对阿尔茨海默氏病的持续时间明显较小，血管危险因素（VRF）的患病率更高。此外，睡眠问题和VRF经常同时发生。更重要的是，确定阿尔茨海默氏病认知能力下降风险较高的无症状黑人对于防止黑人的发作至关重要。 Bubu博士的研究建议侧重于SWS和VRF在黑人和西班牙裔白人之间与AD相关差异的中介作用的横截面和纵向关系（目标1-3）。该提案代表了具有强大理论基础的新，原始和假设驱动的作品。预计每个目标都将导致已发表的手稿和数据，这将直接告知并塑造未来的R01应用程序。该培训和研究计划将使Bubu博士能够成为健康行为影响的独立研究人员和领导者，特别是睡眠和VRF对黑人的晚期认知功能。