The mediating role of Slow Wave Sleep and Vascular Risk Factors on Alzheimer Disease related disparity between African-Americans and non-Hispanic Whites

慢波睡眠和血管危险因素对非裔美国人和非西班牙裔白人之间阿尔茨海默病相关差异的中介作用

• 批准号: 10621181
• 负责人: OMONIGHO A MICHAEL Bubu
• 金额: $ 18.8万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-15 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10621181
• 关键词: Address; Advisory Committees; Affect; African American; African American population; African ancestry; Age; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer' s disease risk; Alzheimer’s disease biomarker; Amyloid; Amyloid beta-42; Amyloid beta-Protein; Amyloid deposition; Area; Automobile Driving; Autopsy; Award; Behavior; Biological; Biological Assay; Biological Markers; Black Populations; Black race; Blood Vessels; Characteristics; Clinical; Clinical Research; Cognition; Cognitive; Complement; Couples; Data; Data Analyses; Development; Diabetes Mellitus; Diffusion; Disparity; Elderly; Electroencephalography; Excessive Daytime Sleepiness; Fellowship; Foundations; Framingham Heart Study; Funding; Funding Mechanisms; Future; Goals; Grant; Health Disparities Research; Health behavior; High Prevalence; Hispanic; Home; Hypertension; Image; Immunoprecipitation; Impaired cognition; Individual; Interdisciplinary Study; Internships; Intervention; Jackson Heart Study; Lesion; Magnetic Resonance Imaging; Manuscripts; Mass Spectrum Analysis; Measures; Mediating; Medical center; Mentors; Mentorship; Methods; Minority; Nerve Degeneration; Neuroepidemiology; Neurology; Neuropsychology; Neurosciences Research; New York; Not Hispanic or Latino; Obstructive Sleep Apnea; Parents; Participant; Pathologic; Physiological; Physiology; Plasma; Polysomnography; Positron-Emission Tomography; Postdoctoral Fellow; Procedures; Psychiatry; Public Health; Publishing; Race; Recording of previous events; Research; Research Personnel; Research Proposals; Research Training; Resources; Risk; Risk Assessment; Role; Shapes; Sleep; Sleep Disorders; Sleep disturbances; Slow-Wave Sleep; Testing; Training; Underserved Population; United States National Institutes of Health; Work; age related; aging brain; biomarker identification; cardiovascular risk factor; career development; clinical practice; clinical training; cognitive change; cognitive function; cohort; comorbidity; design; diagnostic value; disease disparity; educational atmosphere; experience; high risk; improved; in vivo; indexing; innovation; medical schools; minimal risk; molecular marker; multimodality; neurofilament protein L; neuroimaging; new therapeutic target; novel; parent grant; population health; pre-clinical; prevent; professor; programs; prospective; racial difference; screening; sleep quality; tau Proteins; unethical; uptake; vascular risk factor; white matter; β-amyloid burden

PROJECT SUMMARY/ABSTRACT: This K23 resubmission is for Dr. Bubu, an Assistant Professor at NYU School of Medicine (NYUSoM), in the Departments of Psychiatry and Population Health, who is fully committed to becoming an independently funded investigator studying how age-related and age-dependent sleep changes, and vascular risk, impact cognitive decline and Alzheimer’s disease (AD) risk, and how they drive AD related disparities. His unique background makes him an ideal candidate for this field of research. Dr. Bubu has graduate, internship, and fellowship-level clinical and research training in neurology, neuro-epidemiology and public health. He is a graduate of the NYU’s NIH-funded Program to provide Congruent Mentorship to Reach Academic Diversity in Neuroscience Research (1R25NS094093-01), and was recently supported as a postdoctoral fellow at NYUSoM Department of Population Health under a T32 funding mechanism (T32HL129953). He was recently awarded the NIA funded Columbia Center for Interdisciplinary Research on Alzheimer’s disease Disparities Pilot (CIRAD; P30 AG059303) grant to conduct original research on the interaction of obstructive sleep apnea (OSA) and race on plasma tau, and neurofilament light protein. Career development and training plan: Dr. Bubu’s training plan in health disparities research and MRI/PET data analysis couples an outstanding research and education environment at NYUSoM and nearby world-renowned medical centers in the New York Manhattan area with nationally renowned expert mentors. His advisory committee is comprised of Drs. Jean-Louis (primary mentor and expert in health disparity research at NYU), Osorio (co-primary mentor and expert in healthy brain aging and neurodegeneration, at NYU), Ayappa (co-mentor and expert in sleep/OSA physiology, at Mount Sinai), Ogedegbe (adviser and expert in CVD disparity research at NYU), de Leon (adviser and expert in AD neuroimaging and biomarkers at Weill Cornell), and Manly (consultant and expert in neuropsychological methods in underserved populations at Columbia). His training plan features carefully designed coursework and hands-on training experiences. Research plan: Slow wave sleep (SWS) and vascular risk are associated with AD risk. Black/African-American older adults are disproportionately affected by Alzheimer’s disease, have significantly less SWS duration and higher prevalence of vascular risk factors (VRFs) for Alzheimer’s disease, compared to whites. In addition, sleep problems and VRFs often co-occur. More importantly, identifying asymptomatic blacks at higher risk of cognitive decline from Alzheimer’s disease is crucial to preventing its onset among blacks. Dr. Bubu’s research proposal focuses on both cross-sectional and longitudinal relationships (Aims 1 -3) of the mediating role of SWS and VRFs on AD related disparity between blacks and on-Hispanic whites. This proposal represents new, original, and hypothesis-driven work with a strong theoretical foundation. It is expected that each Aim will result in published manuscripts and data, which will directly inform and shape future R01-applications. This training and research plan will enable Dr. Bubu to become an independent researcher and leader in the impact of health behaviors, specifically sleep and VRFs on late-life cognitive functioning in blacks.

项目摘要/摘要： 此 K23 重新提交的对象是纽约大学医学院 (NYUSoM) 的助理教授 Bubu 博士， 精神病学和人口健康系，完全致力于成为一名独立资助的研究人员，研究与年龄相关和年龄依赖性的睡眠变化以及血管风险如何影响认知能力下降和阿尔茨海默氏病（AD）风险，以及它们如何驱动 AD 相关的差异。他独特的背景使他成为该研究领域的理想人选。 Bubu 博士接受过神经病学、神经流行病学和公共卫生方面的研究生、实习和研究员级别的临床和研究培训。他毕业于纽约大学 NIH 资助的项目，该项目旨在提供一致指导以实现神经科学研究的学术多样性 (1R25NS094093-01)，最近在 T32 资助机制 (T32HL129953) 下获得纽约大学医学院人口健康部的博士后研究员支持。他最近获得了 NIA 资助的哥伦比亚阿尔茨海默病差异试点跨学科研究中心 (CIRAD; P30 AG059303) 的资助，以开展关于阻塞性睡眠呼吸暂停 (OSA) 与血浆 tau 和神经丝轻蛋白的种族相互作用的原创研究。 职业发展和培训计划：Bubu博士在健康差异研究和MRI/PET数据分析方面的培训计划 NYUSoM 及其附近纽约曼哈顿地区的世界知名医疗中心拥有出色的研究和教育环境，并拥有全国知名的专家导师。他的顾问委员会由博士组成。 Jean-Louis（纽约大学健康差异研究首席导师和专家）、Osorio（纽约大学健康大脑老化和神经退行性疾病联合首席导师和专家）、Ayappa（西奈山睡眠/OSA生理学联合导师和专家）、Ogedegbe（纽约大学心血管疾病差异研究顾问和专家）、de Leon（AD神经影像和神经影像学顾问和专家） 威尔康奈尔大学的生物标志物）和曼利（哥伦比亚大学服务不足人群的神经心理学方法顾问和专家）。他的培训计划包括精心设计的课程和实践培训经验。 研究计划：慢波睡眠（SWS）和血管风险与 AD 风险相关。黑人/非裔美国人老年人 与白人相比，成年人受阿尔茨海默病的影响尤为严重，其 SWS 持续时间明显较短，阿尔茨海默病血管危险因素 (VRF) 的患病率较高。此外，睡眠问题和 VRF 经常同时发生。更重要的是，识别出因阿尔茨海默氏病认知能力下降风险较高的无症状黑人对于预防该病在黑人中发病至关重要。 Bubu 博士的研究提案重点关注 SWS 和 VRF 对黑人和西班牙裔白人之间 AD 相关差异的中介作用的横向和纵向关系（目标 1 -3）。该提案代表了具有坚实理论基础的新颖、原创和假设驱动的工作。预计每个目标都会产生已发表的手稿和数据，这将直接影响和塑造未来的 R01 应用。这项培训和研究计划将使 Bubu 博士成为一名独立研究员和领导者，研究健康行为，特别是睡眠和 VRF 对黑人晚年认知功能的影响。

项目成果

Sleep Disturbance and Strain Among Caregivers of Persons Living With Dementia.

• DOI: 10.3389/fnagi.2021.734382
• 发表时间: 2021
• 期刊: Frontiers in aging neuroscience
• 影响因子: 4.8
• 作者: Osakwe ZT;Senteio C;Bubu OM;Obioha C;Turner AD;Thawani S;Saint Fleur-Calixte R;Jean-Louis G
• 通讯作者: Jean-Louis G

Association Between Documented Severe Pain and Cognitive Impairment in Home Health Care Patients: Results from the National Outcome and Assessment Information Set Data.

家庭保健患者记录的严重疼痛与认知障碍之间的关联：来自国家结果和评估信息集数据的结果。

• DOI: 10.1089/jpm.2023.0016
• 发表时间: 2023
• 期刊: Journal of palliative medicine
• 影响因子: 2.8
• 作者: Osakwe,ZainabToteh;Calixte,Rose;Bubu,OmonighoMichael;Reckrey,JenniferM
• 通讯作者: Reckrey,JenniferM

The effects of social support and support types on continuous positive airway pressure use after 1month of therapy among adults with obstructive sleep apnea.

患有阻塞性睡眠呼吸暂停的成人治疗 1 个月后，社会支持和支持类型对持续气道正压使用的影响。

• DOI: 10.1016/j.sleh.2023.10.013
• 发表时间: 2024
• 期刊: Sleep health
• 影响因子: 4.1
• 作者: Williams,NatashaJ;Grant,AndreaBarnes;Butler,Mark;Ebben,Matthew;Belisova-Gyure,Zuzana;Bubu,OmonighoM;Jean-Louis,Girardin;Wallace,DouglasM
• 通讯作者: Wallace,DouglasM

Obstructive Sleep Apnea and Alzheimer's Disease Pathology: Is Sleep Architecture the Missing Key?

阻塞性睡眠呼吸暂停和阿尔茨海默病病理学：睡眠结构是缺失的关键吗？

• DOI: 10.3233/jad-231385
• 发表时间: 2024
• 期刊: Journal of Alzheimer's disease : JAD
• 作者: Gills,JoshuaL;Bubu,OmonighoM
• 通讯作者: Bubu,OmonighoM

The Neutrophil to Lymphocyte Ratio Is Associated With the Risk of Subsequent Dementia in the Framingham Heart Study.

• DOI: 10.3389/fnagi.2021.773984
• 发表时间: 2021
• 期刊: Frontiers in aging neuroscience
• 影响因子: 4.8
• 作者: Ramos-Cejudo J;Johnson AD;Beiser A;Seshadri S;Salinas J;Berger JS;Fillmore NR;Do N;Zheng C;Kovbasyuk Z;Ardekani BA;Bubu OM;Parekh A;Convit A;Betensky RA;Wisniewski TM;Osorio RS
• 通讯作者: Osorio RS