Environment Exposure & Neurotoxicology Core

环境暴露

• 批准号: 9491505
• 负责人: Constantinos Sioutas
• 金额: $ 35.31万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9491505
• 关键词: Aerosols; Aging; Air; Air Pollution; Alzheimer' s disease risk; Ammonium; Animal Model; Animals; Biological Assay; Brain; CD36 gene; Carbon; Cell Line; Cells; Chemicals; Chromatography; Collection; Complement 5a; Coupled; Data; Environment; Environmental Exposure; Freezing; Funding; Geography; Heterogeneity; Human; IL6 gene; Individual; Inhalation; Inhalation Exposure; Interleukin-10; Ions; Liquid substance; Location; Los Angeles; Magnetism; Mass Spectrum Analysis; Memory; Modeling; Monitor; Multi-Ethnic Study of Atherosclerosis; Mus; Nitrates; Ozone; Particulate; Particulate Matter; Plasma; Population; Population Heterogeneity; Population Study; Proteins; Protocols documentation; Publishing; Research Infrastructure; Sampling; Site; Standardization; Suspensions; TLR4 gene; TNF gene; Technology; Testing; Trace Elements; Trace metal; Twin Studies; United States National Institutes of Health; Unspecified or Sulfate Ion Sulfates; Vietnam; Washington; Water; Western Blotting; Women' s Health; Work; ambient air pollution; aqueous; base; brain cell; cohort; cytokine; data resource; design; epidemiology study; experimental study; in vivo; innovation; nanosized; neurotoxic; neurotoxicology; planetary Atmosphere; population based; residence; response; spatiotemporal; tool; traffic-related air pollution; ultrafine particle

Environmental Exposures and Neurotoxicology Core (Core C) Director, C Sioutas, Co-Directors: JC Chen and H Forman Abstract The Environmental Exposures and Neurotoxicology Core C, directed by C. Sioutas, includes three supporting subcores to serve the proposed scientific projects, through the provision of the residence-specific exposure estimates in populations, standardization of the inhalation exposure experiments in animal models, and analyses of the neurotoxic responses to traffic-related air pollution (TRAP). SubCore C1, Environmental Data Support (coDir: JC Chen) provides Projects 1 and 2 with individual-level, location-specific estimates of long- term TRAP exposure, using state-of-the-art spatio-temporal modeling approaches harmonized across two human population-based cohorts. Subcore C2, Collection of TRAP-nPM (Dir: C.Sioutas) supplies experimental Projects 3 and 4 with well-characterized TRAP inhalation exposure atmospheres. TRAP are sampled near urban sites impacted by traffic emissions. SubCore C3, Brain Cell Responses to TRAP-PM (coDir: H. Forman) (i) tests individual batches of collected nPM using THP-1 cells for cytokine expression; and (ii) Western blot assay of brain protein changes to in vivo nPM exposure for Projects 3 & 4.

环境暴露与神经毒理学核心（核心C）