Trans-omics integration of multi-omics studies for male osteoporosis
Trans-omics integration of multi-omics studies for male osteoporosis
批准号:
10216820
负责人:
HONG-WEN DENG
金额:
$181.93万
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
已结题
起止时间:
2017-09-15 至 2022-08-31
关键词:
AddressAffectAfrican AmericanAgeAgingAreaBackBacteriaBioinformaticsBloodCOVID-19COVID-19 patientCOVID-19 susceptibilityCOVID-19 testCOVID-19 treatmentCardiovascular systemCessation of lifeChinaCohort StudiesCommunitiesDataData CollectionDeath RateDietDisease OutbreaksEconomicsElectronic MailEnrollmentEthnic OriginFollow-Up StudiesFutureGenderGene ExpressionGenesGenomeGenomicsHealthHealth systemHealthcare SystemsHospitalizationHospitalsHumanHypertensionIndividualInfectionKidneyLife StyleLong-Term EffectsLongitudinal StudiesLouisianaMedicalMetagenomicsMolecularMolecular GeneticsMultiomic DataNoseObesityOsteoporosisOutcomeParticipantPathway interactionsPharmaceutical PreparationsPhenotypePopulationPositioning AttributeQuestionnairesRecording of previous eventsResearchReverse Transcriptase Polymerase Chain ReactionSARS-CoV-2 infectionSARS-CoV-2 positiveSalivaSamplingSerologySerumSeveritiesSeverity of illnessSocioeconomic StatusSpecimenStudy SubjectSymptomsTechnologyTelephoneTestingText MessagingTimeTranscriptUrineVariantage groupagedantibody testbasecaucasian Americancohortcomparativedisorder preventiondrug repurposingeffective interventiongut microbiomehigh riskhost microbiomein vivoindividual responseindividual variationinfection rateinfection riskmalemetabolomemetabolomicsmonocytemultiple omicsnervous system disorderpandemic diseaseparent projectperipheral bloodpersonalized medicinephenotypic datarecruitresponsesexsocialstool sampletranscriptomicsurgent care
中文摘要
项目总结
英文摘要
PROJECT SUMMARY
COVID-19 is a global pandemic, causing a medical and social-economic crisis. There are large variations of
symptoms/outcomes in individual responses to SARS-CoV-2 infection. A key question is: what extrinsic
(aging/environmental/medical/medication/lifestyle/diet/metagenomic) and intrinsic (e.g., genomic/transcript-
omic/metabolomic) factors underlie individual variation in COVID-19 susceptibility, severity and outcomes?
We propose to timely address the above question here. We will leverage on an existing unique cohort of 1,055
Caucasian and African American recruited/phenotyped/profiled with cutting-edge multi-omics technologies in the
Greater New Orleans (GNO) area for our ongoing U19 parent project (U19AG055373) and the larger LOS
(Louisiana Osteoporosis Study) cohort with >16,400 subjects (all ethnicities, both sexes, aged 17-97 years old).
GNO is one of the hardest hit areas in US by COVID-19. We are in a unique position to fulfill the following:
Subject Recruitment and Data Collection: From the U19 and LOS cohorts, we will recruit >400 subjects with
COVID-19 and matched controls, all with confirmed infection status, and obtain the needed biospecimens from them.
We will also recruit and collect phenotypic information and biospecimens from 600 COVID-19 patients through
Ochsner Health System, Louisiana’s largest healthcare system. For the U19 and LOS cohorts, we will be in a
unique position to leverage their existing pre-infection (baseline) multi-omics profiles. For all the recruited
COVID19 subjects, we will assess their post-infection multi-omics profiles, to pursue the following:
Aim 1: Identify potential genes/bacteria species/molecular pathways in human hosts and gut microbiome
that influence susceptibility of COVID-19, by comparative multi-omics analyses of those COVID19 infected
subjects with pre-infection multi-omics data and their matched controls.
Aim 2: Identify aging/environmental/genetic/molecular factors associated with disease severity, by
comparing individual conditions (aging, gender, ethnicity, diet, medical, medication, lifestyle, etc.) and post-infection
multi-omics profiles among >1,000 COVID19 infected subjects with various disease severities/outcomes.
Aim 3: Identify potential causal molecular factors for disease severity, by comparing the pre-infection (baseline)
multi-omics profiles and changes in multi-omics profiles (post- vs. pre-infection) among the COVID19 infected
subjects with various disease severities/outcomes.
Aim 4: Perform bioinformatic analyses for drug repurposing to identify existing drugs that would effectively
treat COVID-19, based on the molecular mechanisms gained in vivo in humans from the multi-omics data.
This study will gain significant information on the fundamental mechanisms underlying individual variation in COVID-
19 susceptibility/severity/outcomes, and pave the way for personalized medicine (especially those targeting various
age groups/medical conditions) using existing drugs as urgent responses. The data/samples/cohorts obtained will
be invaluable for studying the long-term effects of COVID-19 on health, especially aging, in future follow-up studies.
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会议论文
Project 1: Genome Wide Sequencing for Osteoporosis Risk Genes in Males
-
批准号:10180818
-
项目类别:
-
资助金额:$72.49万
-
财政年份:2017
-
负责人:HONG-WEN DENG
-
依托单位:
Decoding Methylation Mediated Epigenomic Contributions to Male Osteoporosis
-
批准号:9905489
-
项目类别:
-
资助金额:$62.0万
-
财政年份:2017
-
负责人:HONG-WEN DENG
-
依托单位:
Trans-omics integration of multi-omics studies for male osteoporosis
-
批准号:10180814
-
项目类别:
-
资助金额:$170.58万
-
财政年份:2017
-
负责人:HONG-WEN DENG
-
依托单位:
Administrative Core
-
批准号:10180815
-
项目类别:
-
资助金额:$20.55万
-
财政年份:2017
-
负责人:HONG-WEN DENG
-
依托单位:
Trans-omics integration of multi-omics studies for male osteoporosis
-
批准号:9916677
-
项目类别:
-
资助金额:$154.07万
-
财政年份:2017
-
负责人:HONG-WEN DENG
-
依托单位:
Epigenomewide DNA Methylation Study for Osteoporosis Risk
-
批准号:9138957
-
项目类别:
-
资助金额:$60.55万
-
财政年份:2012
-
负责人:HONG-WEN DENG
-
依托单位:
Epigenomewide DNA Methylation Study for Osteoporosis Risk
-
批准号:8368888
-
项目类别:
-
资助金额:$65.12万
-
财政年份:2012
-
负责人:HONG-WEN DENG
-
依托单位:
Epigenomewide DNA Methylation Study for Osteoporosis Risk
-
批准号:8536726
-
项目类别:
-
资助金额:$59.4万
-
财政年份:2012
-
负责人:HONG-WEN DENG
-
依托单位:
Genome Wide Scans for Female Osteoporosis
-
批准号:8326789
-
项目类别:
-
资助金额:$5.97万
-
财政年份:2011
-
负责人:HONG-WEN DENG
-
依托单位:
OD Co-funding (-03 Budget Period)
-
批准号:8326792
-
项目类别:
-
资助金额:$97.5万
-
财政年份:2011
-
负责人:HONG-WEN DENG
-
依托单位:
Identification of Proteins Important for Male Osteoporosis
-
批准号:8143422
-
项目类别:
-
资助金额:$62.0万
-
财政年份:2009
-
负责人:HONG-WEN DENG
-
依托单位:
Genetics of Osteoporotic Fractures in Chinese
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批准号:8117113
-
项目类别:
-
资助金额:$6.33万
-
财政年份:2009
-
负责人:HONG-WEN DENG
-
依托单位:
Genome-wide association study of periodontitis
-
批准号:8311274
-
项目类别:
-
资助金额:$1.73万
-
财政年份:2009
-
负责人:HONG-WEN DENG
-
依托单位:
Proteome-wide Expression Study of Osteogenic Cells
-
批准号:7936857
-
项目类别:
-
资助金额:$1.94万
-
财政年份:2009
-
负责人:HONG-WEN DENG
-
依托单位:
Identification of Proteins Important for Male Osteoporosis
-
批准号:8535075
-
项目类别:
-
资助金额:$53.71万
-
财政年份:2009
-
负责人:HONG-WEN DENG
-
依托单位:
Identification of Proteins Important for Male Osteoporosis
-
批准号:7742808
-
项目类别:
-
资助金额:$65.93万
-
财政年份:2009
-
负责人:HONG-WEN DENG
-
依托单位:
Identification of Proteins Important for Male Osteoporosis
-
批准号:8259560
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2009
-
负责人:HONG-WEN DENG
-
依托单位:
OD Co-funding (-03 Budget Period)
-
批准号:7936858
-
项目类别:
-
资助金额:$97.5万
-
财政年份:2009
-
负责人:HONG-WEN DENG
-
依托单位:
Biostatistics and Bioinformatics Core
-
批准号:7936860
-
项目类别:
-
资助金额:$2.72万
-
财政年份:2009
-
负责人:HONG-WEN DENG
-
依托单位:
Genome Wide Scans for Female Osteoporosis
-
批准号:7936855
-
项目类别:
-
资助金额:$3.27万
-
财政年份:2009
-
负责人:HONG-WEN DENG
-
依托单位:
海外基金