Administrative Core

项目总结 这项提议的U19计划项目(PPG)是开创一种综合/新颖的多学科方法 多组学数据的跨组学综合分析研究骨质疏松风险的(表观)遗传基础 男性。为了确保PPG的顺利运作，这一行政核心是必要的，其目标是 提供强有力的领导(在研究、教育和服务方面)，高效地协调互动和 协作努力，有效的管理(人事和预算)支持，以及高效的促进总体 PPG的运作。核心将成为促进信息交流和协作的增效剂， PPG内部的个别项目/核心，以及PPG调查员与PPG以外的项目/核心的合作。供所有人使用 作为PPG的其他组成部分，核心将成为我们当地研究和指导活动的组成部分 机构研究中心，以高效和成本效益的方式使用管理和人力资源。 这个核心包括主任，邓博士，副主任，Deininger博士，助理主任，沈博士，所有人 都很有经验。它们将共同提供强大的行政、管理和领导能力 通过下列活动确保PPG顺利运作和最大限度地提高生产力： ·提供称职和及时的行政服务 ·协调PPG项目、核心和人员的努力 ·加强与国家卫生研究院工作人员和科学家的对话，加强与国家卫生研究院内部的合作关系 和外部咨询委员会，以及与各部门和机构的同事 ·为正在进行的研究提供进度和生产力评估以及内部质量控制 ·将PPG参与的好处扩展到初级教师、博士后研究员和学生的指导 ·协调地方和国家/国际一级的科学讲座和互动演讲 ·组织研究和科学活动及会议，并举办与以下方面有关的科学专题讨论会 PPG研究主题 ·为预算规划和审查、编写赠款报告和手稿等提供支助 ·确保遵守领导期望、政府政策和机构指令 ·协调PPG和其他由地方/国立卫生研究院资助的项目的执行 ·提供和监测PPG内部/外部数据共享，以促进研究和数据挖掘 核心服务的使用将取决于实践中的微调，主要取决于1) 被认为与核心目标和具体目标相关的其他个别项目/核心；2)协调 董事与其他U19 PPG调查人员。核心服务的质量将主要基于 关于内部反馈和自我审查/评估，并在必要时进行测量和改进 内部/外部咨询委员会的反馈和建议。

PROJECT SUMMARY This proposed U19 program project (PPG) is to pioneer a comprehensive/novel approach of multidisciplinary integrative trans-omics analyses of multi-omics data for studying the (epi-)genetic basis of osteoporosis risk for males. To ensure smooth functioning of the PPG, this Administrative Core is necessary, with the Objectives to provide strong leadership (in research, education, and service), productive coordination of interactive and collaborative effort, effective managerial (personnel and budgetary) support, and efficient facilitation for the overall operation of the PPG. The Core will serve as a synergizer to foster information exchange and collaboration, for individual projects/cores within the PPG, and for PPG investigators with those outside the PPG. To be used by all the other PPG components, the Core will be an integrated part of the research and mentoring activities at our local institutional research center, to yield efficient and cost-effective use of management and personnel resources. This core includes Director, Dr. Deng, Associate Director, Dr. Deininger, and Assistant Director, Dr. Shen, all are experienced. They together will furnish strong administrative, management and leadership capabilities for ensuring smooth functioning and maximum productivity of the PPG, through the following activities: • Delivering competent and timely administrative services • Coordinating the efforts of the PPG projects, cores, and personnel • Strengthening dialogue with NIH staff and scientists, enhancing collaborative relationship with the Internal and External Advisory Boards and with colleagues across departments and institutions • Providing progress and productivity evaluation and internal quality control of ongoing research • Extending the benefits of PPG participation to mentoring of junior faculty, postdoctoral fellows, and students • Coordinating scientific lectures and interactive presentations locally and at national/international levels • Organizing research and scientific activities and meetings, and developing scientific symposiums relevant to the PPG research theme • Providing support for, e.g., budgetary planning and review, preparation of grant reports and manuscripts • Assuring compliance with leadership expectations, governmental policies and institutional directives • Coordinating implementation of the PPG and other local/NIH funded projects • Providing and monitoring within-/outside-PPG data sharing for facilitation of the research and data mining The use of the Core services will be, subject to fine-tunes in practice, largely determined by 1) the need of the other individual projects/cores as deemed relevant to the Core’s Objectives and Specific Aims, and 2) coordination of the Directors with other U19 PPG investigators. The quality of the Core services will be measured mainly based on the internal feedbacks and self-review/evaluation, and also be measured and improved if necessary based on the feedbacks and recommendations from the In-/Ex-ternal Advisory Boards.